DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WRNexo and wrn

DIOPT Version :9

Sequence 1:	NP_001163646.1	Gene:	WRNexo / 42208	FlyBaseID:	FBgn0038608	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_009302246.2	Gene:	wrn / 569495	ZFINID:	ZDB-GENE-070702-2	Length:	1387	Species:	Danio rerio

Alignment Length:	196	Identity:	60/196 - (30%)
Similarity:	98/196 - (50%)	Gaps:	10/196 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 EKLPFIKYKGAIKYFTESQDIAASADDVLQWVEKQKDEVVPMAFDMEWPFSFQTGPGKS-AVIQI 182
            :.||::::.|.:.|..|..|.:..::|:...:....    .:.||:|||.||..|..|. |::|:
Zfish    30 DHLPYLEFGGTVVYSQERHDCSFLSEDLRSALSSGS----AVGFDLEWPPSFTKGKTKKVAMVQL 90

  Fly   183 CVDEKCCYIYQLTNVKKLPAALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKCVDLG 247
            |..|..||::.::::...|..|...:....:...||.|:.|..||..|:     :..::..|||.
Zfish    91 CASEDKCYLFHISSMSGFPPGLKMFLEDENIMKVGVGIEGDKWKLLSDY-----DIKLKNIVDLS 150

  Fly   248 LWCNEVCETGGRWSLERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYREL 312
            ...||......:|||:.|...:.||.:.|.|.||.|.|....|.|:|..|||.|.|.|.:||::|
Zfish   151 DLANEKLRCCEKWSLDGLVKHLLKKQLFKDKLVRCSHWDDFSLTEDQKRYAATDAYAGLLIYQKL 215

  Fly   313 E 313
            :
Zfish   216 Q 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WRNexo	NP_001163646.1	WRN_exo	142..314	CDD:176653	54/173 (31%)
wrn	XP_009302246.2	WRN_exo	48..217	CDD:176653	55/178 (31%)
		DEXDc	433..901	CDD:331760
		HRDC	1045..1116	CDD:322002
		HTH_40	1155..1242	CDD:316965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910