DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WRNexo and Exd2

DIOPT Version :9

Sequence 1:	NP_001163646.1	Gene:	WRNexo / 42208	FlyBaseID:	FBgn0038608	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001247048.1	Gene:	Exd2 / 41374	FlyBaseID:	FBgn0037901	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	179	Identity:	47/179 - (26%)
Similarity:	74/179 - (41%)	Gaps:	20/179 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DDVLQWV----EKQKDEVVPMAFDMEWPFSFQTGPGKS--AVIQICVDEKCCYIYQLTNVKKLPA 202
            |...|||    :........:.||.||   ...|..:.  |::|:......|.:::|.::|::|.
  Fly    60 DPTTQWVLNELKNHCQTFKVLGFDCEW---ITVGGSRRPVALLQLSSHRGLCALFRLCHMKQIPQ 121

  Fly   203 ALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKCVDLGLWCNEVCETGGR--WSLERL 265
            .|..|:....|...||..:.|..||:.|:....|..|     ||..    :|...|.  ..|.:|
  Fly   122 DLRELLEDDSVIKVGVAPQEDAMKLSHDYGVGVASTL-----DLRF----LCVMAGHKPEGLGKL 177

  Fly   266 TNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQVIYRELER 314
            :.......:||..::..|.|....|:..||.|||.|..:...||::|.|
  Fly   178 SKTHLNYTLDKHWRLACSNWEAKTLEPKQLDYAANDALMAVAIYQKLCR 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WRNexo	NP_001163646.1	WRN_exo	142..314	CDD:176653	46/177 (26%)
Exd2	NP_001247048.1	WRN_exo	62..226	CDD:176653	45/175 (26%)
Exd2	NP_001247048.1	Cas8a1_I-A	363..432	CDD:328770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910