DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WRNexo and exd2

DIOPT Version :9

Sequence 1:	NP_001163646.1	Gene:	WRNexo / 42208	FlyBaseID:	FBgn0038608	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001107878.1	Gene:	exd2 / 334455	ZFINID:	ZDB-GENE-030131-6387	Length:	617	Species:	Danio rerio

Alignment Length:	294	Identity:	66/294 - (22%)
Similarity:	108/294 - (36%)	Gaps:	59/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AAKRKNLDTPDVKTEKLAMEEENPPKRRSSRLTRSTRSMAEDGSPSPEKEKP-------EKLPFI 124
            |.|:|........||.:..:.:            :....:::.|..|..:||       |:.|.:
Zfish    30 AQKKKKTLASAAPTEPILAQRD------------AVLQPSQEPSAPPVSQKPLRAHTLLEEPPVV 82

  Fly   125 KYKGAIKYFTESQDIAASADDVLQWVEKQKD-EVVP-MAFDMEW----PFSFQTGPGKSAVIQIC 183
                          |::..|....|...||| .:.| :..|.||    ..|.:......:::|:.
Zfish    83 --------------ISSPQDWDNLWPALQKDLSMYPVLGLDCEWVKRVRVSVKGRVSAVSLLQLS 133

  Fly   184 VDEKCCYIYQLTNVK--KLPAALVALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEKC-VD 245
            .....|.:.:|...:  :||.:|:.|:...:|...||....|.::||:|      ..|...| ||
Zfish   134 SFTGRCVLVRLLAFQNAQLPKSLIVLLRDQRVLKVGVGCYEDGKRLAQD------HGLTLSCTVD 192

  Fly   246 LGLWC----NEVCETGGRWSLERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMYAAIDVYIGQ 306
            |....    .:...|.| .||:.|...:....:|||.::|.|.|....|...|:.|||.|..|..
Zfish   193 LRYLALRRSKQAVLTNG-LSLKSLAEDLLNVTLDKSVELRCSDWEAEELSPEQITYAARDAQISI 256

  Fly   307 VIYRELERREKVKIKNEEEFKEKNGDAAFKAMKA 340
            .::..|..      .|.|......|:|.|..:.|
Zfish   257 ALFFHLLG------MNTERHLPAEGEAVFLHLSA 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WRNexo	NP_001163646.1	WRN_exo	142..314	CDD:176653	48/184 (26%)
exd2	NP_001107878.1	WRN_exo	83..263	CDD:176653	48/186 (26%)
exd2	NP_001107878.1	RRXRR	357..>399	CDD:290939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910