DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WRNexo and mut-7

DIOPT Version :9

Sequence 1:	NP_001163646.1	Gene:	WRNexo / 42208	FlyBaseID:	FBgn0038608	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_499105.1	Gene:	mut-7 / 176347	WormBaseID:	WBGene00003504	Length:	910	Species:	Caenorhabditis elegans

Alignment Length:	261	Identity:	54/261 - (20%)
Similarity:	104/261 - (39%)	Gaps:	50/261 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EKEKPEKLPFIKYKGAIKYFTESQDIAASADDVLQWVEKQKDEVVP--MAFDMEWPFSFQTG--P 174
            |.|:..::..:|.:..:.|....             ::...||..|  :.||.||..|..|.  .
Worm   397 ENERRTQIHMVKTESEMNYLCSE-------------IKSLSDEPAPVYVGFDSEWKPSNLTAVHD 448

  Fly   175 GKSAVIQICVDEKCCYIYQLTNVKKLPAA-------LVALINHPKVRLHGVNIKNDFRKLARDFP 232
            .|.|:||:.. :.|.::.....::|...|       ...|.....|::.|.:::||...:| ..|
Worm   449 SKIAIIQLFF-KNCVWLVDCVELEKANMADDWWQKFASRLFGDSPVKVVGFDMRNDLDAMA-TIP 511

  Fly   233 EVTAEPLIE---KCVDLGLWCNEVCETG--------GRWSLERLTNFIAKKAMDKSKKVRMSKWH 286
            .:.:...||   ...||......||:..        ..:.|..||:::....:||::  :.|.|.
Worm   512 ALKSSMKIEDTKNAFDLKRLAENVCDIDMEILELPKKTFKLADLTHYLLGLELDKTE--QCSNWQ 574

  Fly   287 VIPLDENQLMYAAIDVYIGQVIYREL----ERREK-------VKIKNEEEFKEKNGDAAFKAMKA 340
            ..||.:.|::|||:|..:....::::    |.:.|       |:..|....|:..|..:::.:|.
Worm   575 CRPLRKKQIVYAALDAVVVVETFKKILSIVEEKNKDADIEKIVRESNVMAPKKDKGHKSYRKLKT 639

  Fly   341 L 341
            :
Worm   640 I 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WRNexo	NP_001163646.1	WRN_exo	142..314	CDD:176653	43/197 (22%)
mut-7	NP_499105.1	mut-7_like_exo	404..602	CDD:176655	45/214 (21%)
mut-7	NP_499105.1	Mut7-C	665..>775	CDD:302879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1295758at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920