DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WRNexo and ZK1098.3

DIOPT Version :9

Sequence 1:	NP_001163646.1	Gene:	WRNexo / 42208	FlyBaseID:	FBgn0038608	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_499104.1	Gene:	ZK1098.3 / 176346	WormBaseID:	WBGene00014220	Length:	784	Species:	Caenorhabditis elegans

Alignment Length:	294	Identity:	64/294 - (21%)
Similarity:	115/294 - (39%)	Gaps:	51/294 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 AKRKNLD------TPDVKTEKLAMEEENPPKRRSSRL-----TRSTRSMAEDGSPSPEKEKPEKL 121
            |...|:|      .||:|.|.     |||.....:.|     .|:|::..|:.......|:.:|.
Worm   361 ATYSNIDRNSKYMPPDLKEEL-----ENPTTEMKNGLEKLQALRTTKNCQEEDEQLYVFEEQKKY 420

  Fly   122 PFIKYKGAIKYFTESQDIAASADDVLQWVEKQKDEVVPMAFDMEW-PFS-FQTGPGKSAVIQICV 184
            |       |:.....||:     ::|.....:.:|.:.:.:|.|: |:. ......:.|:||:..
Worm   421 P-------IRIVQNEQDL-----EILLSELGELEEGMYIGYDSEFKPYHLIDVSTSRLAIIQLFF 473

  Fly   185 DEK-----CCYIYQLTNVKKLPAALV-ALINHPKVRLHGVNIKNDFRKLARDFPEVTAEPLIEK- 242
            .:|     |..|..|.:...:...|. .|....|..:.|.:|:.|...:. ..|.:.....||.
Worm   474 KDKAWLINCVAIDNLASRDDVWIRLYKGLFESNKFSIVGFDIRQDIEAMF-TVPSINKNFKIENI 537

  Fly   243 ----CV-----DLGLWCNEVCETGGRWS-LERLTNFIAKKAMDKSKKVRMSKWHVIPLDENQLMY 297
                ||     ::.....::.....:.| |..|.:.:....||||:  :...|...||..||::|
Worm   538 QNVICVKSLAENVNALSMDILNLSTKTSKLSVLADHLVGLKMDKSE--QCGNWQCRPLRRNQIIY 600

  Fly   298 AAID-VYIGQVIYRELERREKVKIKNEEEFKEKN 330
            |.:| |.:.:|..:.:|...|.::..|:...|.:
Worm   601 AVMDAVAVFEVFQKIVEVVRKHELDAEKLLVESH 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WRNexo	NP_001163646.1	WRN_exo	142..314	CDD:176653	40/191 (21%)
ZK1098.3	NP_499104.1	mut-7_like_exo	422..617	CDD:176655	43/202 (21%)
ZK1098.3	NP_499104.1	Mut7-C	676..>752	CDD:302879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1295758at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010