DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Pard3

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_112514.1	Gene:	Pard3 / 81918	RGDID:	620374	Length:	1337	Species:	Rattus norvegicus

Alignment Length:	670	Identity:	155/670 - (23%)
Similarity:	241/670 - (35%)	Gaps:	228/670 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VEVIDLINDGNGLGFILV-----GGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFS 69
            |:::.:.|||..||..:|     |||:.|:::|.|..||.||::......|.:::|.:.:||...
  Rat   272 VKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRR 336

  Fly    70 SEQVATVLRQTGAQVRLIVARPVEPTA---------------------------IDYQTLACQAP 107
            .||...:.||  |....::...|.|.|                           :..:::|..||
  Rat   337 FEQAQHMFRQ--AMRARVIWFHVVPAANKEQYEQLSQREMNNYSPGRFSPDSHCVANRSVANNAP 399

  Fly   108 -IIP--TKLLSDPEEL--------SRHLFQNPSFATAAVAAAAAAAAAAGS-------------- 147
             .:|  .:|...||:|        |.|....|..| .|:|.....:.:.||
  Rat   400 QALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPTA-PALAPPNVLSTSVGSVYNTKRVGKRLNIQ 463

  Fly   148 ---GSDG----------DVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELA 199
               |::|          .:||...:.|.::  |.||...:...|.|.:           :|.|:.
  Rat   464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNI--LPRGAAIQDGRLKAGD-----------RLIEVN 515

  Fly   200 G-DLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIV----PFSILSPPPRPALQMLPLETQW 259
            | |||         |.....|.......:....:.|.:.    .|........|:....|.||:
  Rat   516 GVDLA---------GKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQSPKETK- 570

  Fly   260 RCVQDQNRHIETVIADSKRKLLANE----DGGSASASGSGSPDSYMDSPETETYVVELHKNVYGL 320
              .:|::   ..:..|..|:.|..|    |.|||                             ||
  Rat   571 --AEDED---IVLTPDGTREFLTFEVPLNDSGSA-----------------------------GL 601

  Fly   321 GITVAGYVCEEE--DLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNT 383
            |::|.|...:|.  || ||||||||.|.||...|::::||:::||:|.||.|..|.:|:|.||.:
  Rat   602 GVSVKGNRSKENHADL-GIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRS 665

  Fly   384 DIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLP 448
                 ::.|    |.|...:|:.:..        .:.|.        ::|..||||:...|
  Rat   666 -----MSTE----GNKRGMIQLIVAR--------RISRC--------NELRSPGSPAAPEL---- 701

  Fly   449 PKSLDADSIATEGDEAVDAE-------YVGISGAEDEFIELPSRDTVES---------------N 491
                   .|.||.|   |.|       |.||.|.:    |.|:|:...|               |
  Rat   702 -------PIETELD---DRERRISHSLYSGIEGLD----ESPTRNAALSRIMGESGKCQLSPTVN 752

  Fly   492 MSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPE 556
            |.|     |.:..:..|::|.:.|          .|:|.|.:.:.:......||.....|.:
  Rat   753 MPH-----DDTVMIEDDRLPVLPP----------HLSDQSSSSSHDDVGFIMTEAGTWAKAT--- 799

  Fly   557 TERVKDLGDTKTDTDPDPDL 576
               :.|..|.....|.||.|
  Rat   800 ---ISDSADCSLSPDVDPVL 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	25/76 (33%)
		PDZ	307..393	CDD:214570	33/87 (38%)
		PDZ_signaling	605..680	CDD:238492
		PDZ	773..858	CDD:214570
Pard3	NP_112514.1	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..263
		PDZ_signaling	272..347	CDD:238492	25/76 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..441		13/44 (30%)
		PDZ_signaling	465..544	CDD:238492	19/100 (19%)
		PDZ_signaling	588..681	CDD:238492	42/131 (32%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269\|PubMed:9763423	712..936		27/130 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1015
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1337
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1055
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900