DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and PDZD7

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	889	Identity:	182/889 - (20%)
Similarity:	279/889 - (31%)	Gaps:	327/889 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LGFILVGGR--STGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLR-QTGAQ 83
            |||.:.||:  ..|:.:..:..||:||.:| :::||.:|....|.....|..|...||: ||  .
Human   222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKGQT--H 283

  Fly    84 VRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQ--NPSFATAAVAAAAAAAAAAG 146
            :.|.:.......|  |:.:..:...:        :.||..:.|  :|:..:::..::.|::|...
Human   284 IMLTIKETGRYPA--YKEMVSEYCWL--------DRLSNGVLQQLSPASESSSSVSSCASSAPYS 338

  Fly   147 SGS--------------DGDVG-GGGVLDVASLV-----GLVR------------------GGPA 173
            |||              .|..| |.|..|.|...     |.|.                  .||.
Human   339 SGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPH 403

  Fly   174 EGTEL-SAVEPQPSAAVLQLQQLSELAGDLADFPLPPI-----------------------PG-- 212
            .|..| ||:...|..|:  |..||.        |.|||                       ||
Human   404 PGRRLDSALSESPKTAL--LLALSR--------PRPPITRSQSYLTLWEEKQQRKKEKSGSPGEK 458

  Fly   213 -------------------------GGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQM 252
                                     |...:...||.:..:..||||::            .|..:
Human   459 GALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDSGSLAKTYPRLDIE------------KAGGV 511

  Fly   253 LPLE--TQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHK 315
            .|::  ..||..:||.|                  |.:..::.||||.|.:.:.:.:....|..:
Human   512 GPVQKFVTWRLRRDQER------------------GRALLSARSGSPSSQLPNVDEQVQAWESRR 558

  Fly   316 NVYG------------LGIT--VAGYVCEE--EDLSGIFVKSIIEGSAAETSGQIQINDR----I 360
            .:..            |.:|  .:.||.|.  |||    |:.:           :.|.||    :
Human   559 PLIQDLAQRLLTDDEVLAVTRHCSRYVHEGGIEDL----VRPL-----------LAILDRPEKLL 608

  Fly   361 VAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERF--LRGRKY---------------EHLQVALT 408
            :..|.||:...|     :|.|...:|:.:.||.|  |:.|..               .||...:.
Human   609 LLQDIRSVVAPT-----DLGRFDSMVMLVELEAFEALKSRAVRPPALRPARQDTPPKRHLITPVP 668

  Fly   409 EIKG---TSAPSGLDRSQDKDQDQESQLSMPGSPSIAT----LSWLPPKSLDADSIATEGDEAVD 466
            :.:|   ....:|....:|..:.:|...::..|||.:.    ...:||..          |..||
Human   669 DSRGGFYLLPVNGFPEEEDNGELRERLGALKVSPSASAPRHPHKGIPPLQ----------DVPVD 723

  Fly   467 AEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDS 531
            |           |..|....|....:..|..|......|..:.:.|..|......||
Human   724 A-----------FTPLRIACTPPPQLPPVAPRPLRPNWLLTEPLSREHPPQSQIRGR-------- 769

  Fly   532 GNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTN---EAPVKAA 593
                           ||:|..|:..:......|..|:.....|...|...|:.||   ..|.||.
Human   770 ---------------AQSRSRSRSRSRSRSSRGQGKSPGRRSPSPVPTPAPSMTNGRYHKPRKAR 819

  Fly   594 SP-------------------------TA--------------ASLRVAWKSLGISLEGTVDVEC 619
            .|                         ||              .:|....:|||||:.|
Human   820 PPLPRPLDGEAAKVGAKQGPSESGTEGTAKEAAMKNPSGELKTVTLSKMKQSLGISISG------ 878

  Fly   620 GIEKR--PHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKEL---PAR--V 677
            |||.:  |...|..|...|.....|.|:.|.||:.|:...|:.:.|...|..::..   .||  :
Human   879 GIESKVQPMVKIEKIFPGGAAFLSGALQAGFELVAVDGENLEQVTHQRAVDTIRRAYRNKAREPM 943

  Fly   678 KLVCARGTHVPSVINTSQNPEAFETRSLLPGG--------HQSL 713
            :||    ..||   ..|..|...::.:|..||        ||.|
Human   944 ELV----VRVP---GPSPRPSPSDSSALTDGGLPADHLPAHQPL 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	22/69 (32%)
		PDZ	307..393	CDD:214570	21/105 (20%)
		PDZ_signaling	605..680	CDD:238492	24/81 (30%)
		PDZ	773..858	CDD:214570
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492	22/69 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		2/19 (11%)
		HN_PDZD7_like	554..630	CDD:259824	19/95 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864		21/132 (16%)
		PDZ_signaling	860..948	CDD:238492	27/97 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033		12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810