DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and dlg5a

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	1063	Identity:	209/1063 - (19%)
Similarity:	342/1063 - (32%)	Gaps:	351/1063 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STEWSQVEVIDLINDGN-----GLGFILVGG-------RSTGVVIKALTPGGVAERDGRLQLGDH 56
            |.|| :.||::...|.:     .:||.:..|       ...|:.:..:..|.:|  ||||::.|.
Zfish   689 SLEW-ETEVVEFEKDRDDMDLKAMGFDIAEGVNDPYLPGDCGIFVSRVDKGSIA--DGRLRVNDW 750

  Fly    57 LLQIGEVNLRGFSSEQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELS 121
            ||:|.:|:|.....:||...:...|..:.::|.|                    .|.|......|
Zfish   751 LLKINDVDLTNKDRKQVIKAVLNGGGLINMVVRR--------------------RKSLGGRLVTS 795

  Fly   122 RHL----FQNPSFATAA---VAAAAAAAAAAGSGS----DGDVGGGGV-LDVASL---VGLVRGG 171
            .|:    .::...|...   ||..|..:.||..||    |..:...|: ||..||   ..|:|||
Zfish   796 VHINLIGHKDAGIALEGGVFVAGIAPGSPAAREGSLTIGDRLIAINGIALDNKSLSECEALLRGG 860

  Fly   172 PAEGTELSAVE--PQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSN----------A 224
             .:...||.::  ||.::.....:.|.|.........|..:......::..:|:          |
Zfish   861 -RDSLALSLMKFFPQSTSGQNIFESLREAEKSNGRIHLTDVHSRNSRNLKHNSSTQTDIYSCDTA 924

  Fly   225 GQRPCPRLDLD--------IVPFSILSPPP-RPALQMLPLE-----------TQWRCVQDQNRHI 269
            |:|...|.|.:        :.|.|.|.|.. |||.::.|:.           |:...|..:...:
Zfish   925 GERRKTRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASAFQEVCYTRSESVGPECVTL 989

  Fly   270 ETVI-------------------ADS-----------KRKLLANED-------------GGSASA 291
            ||.:                   .||           :||.:.:.|             .|....
Zfish   990 ETTLEKKHSGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIFDADTFKRPDTPSKADYHGPQPL 1054

  Fly   292 SGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQI 356
            ....:|........::::..: ||:        .|....|..:|.:   ||.|....:.:|.:..
Zfish  1055 KADSAPTPPTPPTRSDSFKFK-HKH--------QGSSTSESTISAM---SISEPKQEDRNGNLYF 1107

  Fly   357 NDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKY-EHLQVALTEIKGTSAPSGLD 420
            :      :|:.||   :.::.|    .||           ||.: |..:|.....|  |||:...
Zfish  1108 S------EGKVLS---SRKSCE----EDI-----------GRMWAEEPEVKRPRPK--SAPALRR 1146

  Fly   421 R--------------SQDKDQDQESQL--SMPGSPSIATLSW--------LPPKSLDADSIATEG 461
            |              |.|.|..::.::  |.|..|...::.:        |||.|..........
Zfish  1147 RMTPQNIPLQSFQSYSNDGDSVEQREMLRSSPNRPHRHSVGFVPTSYNGTLPPNSAHRGLAPCSA 1211

  Fly   462 DEAVDAEYVGISGAEDEFIELPSRDTVES--NMSHVLDRSDHSGGLTKD---------------- 508
            ..||....|.:  .....:...:..||.|  |..|......|.|.|:.|
Zfish  1212 VTAVMKNPVYM--VRSHRVHTNNCPTVVSQINQQHTHPSPQHQGQLSLDLSQKRSTDYSESSRSS 1274

  Fly   509 -----------------------QVPRISPIVPLT--NGRSLILADDSGNDTDEQCAEP------ 542
                                   :..||.  :|.|  ..|| ||..|.|:.:..:|:.|
Zfish  1275 RASHGTNSLPSSARLGSSNNLQYRTERIK--IPSTPRYPRS-ILGSDRGSLSHSECSSPSLITPP 1336

  Fly   543 ------ETET--AQARKGS-----------KPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEA 588
                  ||.:  :...:||           .|..||.||          .|.|:     .|.|..
Zfish  1337 LSPLNLETSSFASSQSQGSISTLPRISVSPVPTEERRKD----------RPYLE-----EPRNVM 1386

  Fly   589 PVKAASPTAASLRVAWKSLGISL----EGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDE 649
            ..|.|.|           ||||:    .|.:.|             |.:..|.:..|..|..||:
Zfish  1387 VHKGAEP-----------LGISIVSGENGGIFV-------------SKVTGGSIAHQAGLEYGDQ 1427

  Fly   650 LLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFE---TRS------- 704
            ||:.|...|:.....:...|:.:....:.::.....|:..:.|.|::....|   |:|
Zfish  1428 LLEYNGINLRNATEQQARLIIGQQCDTITIMAQYNPHMYQLGNHSRSSSRLEPVSTQSTPQGSGT 1492

  Fly   705 LLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGA----RSKSLENVSGLAL 765
            ..|..|.::..|  ..|.|.:|..||..|..           |....:    .|:|.:.|.
Zfish  1493 ATPDNHSTIDTL--SEQDEGTLTPSSKQTTP-----------TTSPNSFIRMPSESSKKVP---- 1540

  Fly   766 WSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSV--IVIRGLIRGGAAEATNEIYPGDRLMSVGD 828
               |...|.:.||:...|..:..        |::  |.:..|.....|...:.:.|||.::..|.
Zfish  1541 ---EARLVTVRKTQVELGIQLCG--------GNLRGIFVERLEDDSPARGADAVVPGDMILEYGS 1594

  Fly   829 RLLQGLELDEAVSILKAMPPGLT 851
            ..::...::||  .|:.:.|..|
Zfish  1595 VNMKNKTVEEA--YLEMLKPAET 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	20/83 (24%)
		PDZ	307..393	CDD:214570	15/85 (18%)
		PDZ_signaling	605..680	CDD:238492	17/78 (22%)
		PDZ	773..858	CDD:214570	17/81 (21%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018
		Takusan	128..211	CDD:282652
		Taxilin	295..627	CDD:286771
		RILP-like	338..460	CDD:304877
		SH3BP5	444..648	CDD:283045
		PDZ_signaling	696..783	CDD:238492	21/88 (24%)
		PDZ_signaling	793..866	CDD:238492	20/73 (27%)
		PDZ	1381..1463	CDD:214570	22/105 (21%)
		dbPDZ_assoc	1461..1541	CDD:293216	19/99 (19%)
		PDZ	1541..1623	CDD:214570	18/85 (21%)
		SH3_DLG5	1639..1701	CDD:212794
		Guanylate_kin	1780..1949	CDD:279019
		NK	1794..1950	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900