DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and stxbp4

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_009305072.1	Gene:	stxbp4 / 567916	ZFINID:	ZDB-GENE-110420-5	Length:	749	Species:	Danio rerio

Alignment Length:	886	Identity:	182/886 - (20%)
Similarity:	295/886 - (33%)	Gaps:	318/886 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VEVIDLINDGNGLGFILVG------GRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGF 68
            ||.::..:...|||..::|      |...|:.||.:.|||||.:||||:.||.:|.:..:||||.
Zfish    33 VERLEFTDCKKGLGVKIIGGYRGQSGEEFGIFIKRILPGGVAAQDGRLRPGDLILDVNNMNLRGV 97

  Fly    69 SSEQVATVLRQTGA--QVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFA 131
            ::|:...|||...|  .:.|:|.|                           ::.||..|
Zfish    98 TNEKAVEVLRMASATNHMSLLVVR---------------------------DDASRREF------ 129

  Fly   132 TAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTE---LSAVEPQPSAAVLQLQ 193
             ..:.....::::..||||..|..|.:.|.||     ....:..|.   ||..||.|
Zfish   130 -TELMEKYGSSSSTSSGSDTSVSTGKMTDTAS-----SSSSSRSTSPLLLSPKEPSP-------- 180

  Fly   194 QLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQ 258
                                     |..:.....|.|::..|.:            :|::
Zfish   181 -------------------------VYTTACINSPSPQVCTDCM------------IQLI----- 203

  Fly   259 WRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGIT 323
              ||                            |.|:                        |||:.
Zfish   204 --CV----------------------------AKGT------------------------GLGLV 214

  Fly   324 VAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVH 388
            :.|.....|. ..:||:.||:|...:..|:::..|::::::..||.|||:.:|..:|..|.:...
Zfish   215 IRGGANRAEG-PMVFVQEIIQGGDCQKDGRLKSGDQLISINKESLVGVTHEEAKSILTRTKLRPD 278

  Fly   389 LTLE-RFLRGRKYE------HLQVALTEIKGT------SAPSGLDRSQDKDQDQESQLSMPGSPS 440
            .|:| .|:|.|...      |..::|.....|      :.||||           |..::||.
Zfish   279 PTVEIAFIRRRSSSGSSSGPHSPISLQPSCSTNHPAPQTKPSGL-----------SGAALPGG-- 330

  Fly   441 IATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGL 505
                  |.||..:..:                ||:|    .|||   ||               |
Zfish   331 ------LVPKIANTPN----------------SGSE----TLPS---VE---------------L 351

  Fly   506 TKDQVPRISPIV-PLTNGRSLILADDSGNDTDEQCAE-PETETAQARKGSKPETERVKDLGDTKT 568
            ||.:.....|:: |:|:..|             .|.. ...:.:.|...|:|.    |.|...::
Zfish   352 TKVRAATGKPVLAPVTSPES-------------ACTTVANADASAACNPSRPS----KPLCSVQS 399

  Fly   569 DTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTV------DVECGIEKRPH- 626
            .     :|.|.::........:|.|.....:||   :.|.::..|||      .|...:.|:|.
Zfish   400 F-----ELKPEKIDQTLEVLGLKPADSQVLTLR---ERLRLNAGGTVAYGDFDTVTKELFKQPSK 456

  Fly   627 --------HYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLR--HIEVVKILKELPARVKLVC 681
                    ......|.:.|......|...|:|     .:::.||  |||.::.||.|..::.
Zfish   457 LDSEQEVARLTSDDLIESPSNPTPSLSDSDDL-----DEMERLRKEHIEALRELKGLQDKLA--- 513

  Fly   682 ARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGG 746
                               |:.||   .|:.||.|....|...|....|.:..|....|.
Zfish   514 -------------------ESESL---NHKMLQELTKVKQDAKSAVEESRSLRTRIHLAE----- 551

  Fly   747 TAGGGARSKSLENVSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAA 811
            .|...||...::....:.|...|:..:...||||    ...:.:|..|.:..:.|:...:|
Zfish   552 AAQKQARGMEMDYEEVIHLLEAEIAEMKSLKTEQ----PSQEKEDLQDLKKRISVLECQLR---- 608

  Fly   812 EATNEIYPGDRLMSVGDRLLQGLELDEAVSILKAMPPGLTR 852
              .:|:......:|.| :|||.:   |||....:..|..:|
Zfish   609 --KSEVAKKGFQVSTG-KLLQFV---EAVQSFLSENPSASR 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	30/79 (38%)
		PDZ	307..393	CDD:214570	22/86 (26%)
		PDZ_signaling	605..680	CDD:238492	20/91 (22%)
		PDZ	773..858	CDD:214570	19/80 (24%)
stxbp4	XP_009305072.1	PDZ_signaling	40..120	CDD:238492	30/79 (38%)
		PDZ_signaling	207..274	CDD:238492	20/91 (22%)
		RILP-like	486..585	CDD:304877	29/133 (22%)
		WW	695..724	CDD:278809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100