DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and lnx2b

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	488	Identity:	106/488 - (21%)
Similarity:	177/488 - (36%)	Gaps:	127/488 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQVEVIDLIND--GNGLGFILVGGRST---GVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRG 67
            ::..|::|..:  |..||..:|||:.|   .:||:.:....:..|||:|..|||:|::.:|:|..
Zfish   206 AEATVVELFREDPGEDLGLRIVGGKDTPLGNIVIQEIVRDSLVARDGKLAPGDHILEVNDVSLAS 270

  Fly    68 FSSEQVATVLRQTGAQVRLIV-------ARP---VEPTAIDYQTLACQAP--------IIPTKLL 114
            .|..:...|:||..:::||.|       .||   .:|:|    :...|:|        :|...|:
Zfish   271 ISHSRAIAVIRQPCSRLRLTVMQEKGFKPRPEHHTQPSA----SPPTQSPSTNQNHGTVIQVTLV 331

  Fly   115 SD--PEELSRHLFQNPSFATAAVAAAAAAAAAAGSG----SDGDVGGGGVLDVASLVGLVRGGPA 173
            ..  .|.|...|.:........:........||..|    :|..:|..|       ..|..|.|.
Zfish   332 KHERSEALGIKLIRKSEEPGVFILDLLPGGLAAKDGKLRNNDKVLGING-------QDLRHGTPE 389

  Fly   174 EGTE-LSAVEPQPSAAVLQLQQLSELAGD-----LADFPLPPI----------PGGGGHSMVTDS 222
            ...: :.|.|.:.:..|::||.:||..|:     ....|.|..          |.||..|.....
Zfish   390 SAAQIIQASEMRVNFVVMRLQDVSEEGGEGQSRGARRVPEPQYFRRHSEYMKEPPGGFSSQEKTV 454

  Fly   223 NAGQRPCPRLDLDI---------VPFSILSPPP-----------------------------RPA 249
            ...:.|...|.:.|         :|..|.|..|                             ..|
Zfish   455 TLKKEPRQSLGITIAGGRDCRSRLPVYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEA 519

  Fly   250 LQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETY----- 309
            :.:|..:|....|  ..|.|:|...|.:      :||    .|||......|:.|:.:..
Zfish   520 VTVLKTQTAQSTV--TLRVIQTFADDEE------QDG----ESGSREDMDTMEGPKDDDINWVPL 572

  Fly   310 ----------------VVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQIND 358
                            ::.:..|....|.::.|...|.......|:|:|:.|:.|...|:::..|
Zfish   573 WTRWLGLPSCIHWCRDIMLMKTNSESWGFSIVGGYEESRGQQPFFIKTIVPGTPAYFDGRLKCGD 637

  Fly   359 RIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTL 391
            .||||:|.:..|:.|...:.:|:.....|.||:
Zfish   638 EIVAVNGVTTVGMNNSSLIPMLKLQKNKVTLTV 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	26/83 (31%)
		PDZ	307..393	CDD:214570	22/106 (21%)
		PDZ_signaling	605..680	CDD:238492
		PDZ	773..858	CDD:214570
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492	27/80 (34%)
		PDZ_signaling	325..406	CDD:238492	16/87 (18%)
		PDZ_signaling	451..537	CDD:238492	12/87 (14%)
		PDZ_signaling	587..671	CDD:238492	22/84 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000