DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and si:dkey-92j12.5

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_021332028.1	Gene:	si:dkey-92j12.5 / 560912	ZFINID:	ZDB-GENE-090313-354	Length:	1860	Species:	Danio rerio

Alignment Length:	871	Identity:	194/871 - (22%)
Similarity:	294/871 - (33%)	Gaps:	382/871 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQV 73
            |:..::|.|||:||||.::||||||.::|.:.|.|||.:||||:.||.||.||:|::....||:|
Zfish   231 QIYHVELENDGSGLGFGIIGGRSTGTMVKTIIPDGVAGKDGRLRSGDLLLSIGDVDVSEMGSEEV 295

  Fly    74 ATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAVAAA 138
            |..||..|..||||:||.
Zfish   296 AHELRVAGTHVRLIIARE----------------------------------------------- 313

  Fly   139 AAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLA 203

Zfish   314 ----------------------------------------------------------------- 313

  Fly   204 DFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQNRH 268
                           :|||:                    |.|..|||           ||..:.
Zfish   314 ---------------ITDSD--------------------PLPASALQ-----------QDTQKK 332

  Fly   269 IETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEEED 333
            .:||  :.|.|
Zfish   333 QDTV--EQKWK------------------------------------------------------ 341

  Fly   334 LSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGR 398
                      :|:..:..|.|.|...|::|||:     ..|...:  ||.:.::.:|      |:
Zfish   342 ----------KGNTVDKDGHIGIGGHIISVDGK-----IQHDCSK--RNPEEILLIT------GQ 383

  Fly   399 KYE-HLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGD 462
            :.| ||....:..:..:.||           ..:....|.:|    |..|||
Zfish   384 QVELHLPKKCSPCETQTTPS-----------TSTNFQRPLTP----LGLLPP------------- 420

  Fly   463 EAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVP-----LTNG 522
                              .||.|                        :|...|::|     .|..
Zfish   421 ------------------PLPPR------------------------LPEQKPVLPPGKVFYTER 443

  Fly   523 RSLILADDSGNDTDEQCAEPETETAQAR----KGSKPETERVKDLGDTKTDTDPDPDLDPGQMPT 583
            .......:....:...|...:||:...:    |.|..|.:.:|:...:|..
Zfish   444 LDFNFNKECFRSSQTCCLLSKTESRNHKSSCCKLSDDEEKSLKEKWQSKLG-------------- 494

  Fly   584 PTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGD 648
            |..|..|     |.....:....||:|||.         |..||||.|||.:||:|:.||:.|||
Zfish   495 PQYEVLV-----TQVEKFIESSGLGVSLEA---------KEGHHYICSILPEGPLGQTGIIHPGD 545

  Fly   649 ELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSL 713
            ||::||...|.|..|.|||.:|||||..|.:||:|  .:|..::..::.:.          ..:|
Zfish   546 ELIEVNGFSLIGETHKEVVSLLKELPMNVCVVCSR--LIPPRVSEEEDDDV----------QLTL 598

  Fly   714 QNLLSK--AQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLEN----VSGLALWSCEVTA 772
            :.||::  .::|.:::.|..|                   .|.:.|::    :|..|:|..|:..
Zfish   599 KELLAEFNEKAEQNIFGSVFA-------------------LREEDLKSEAPVLSHQAMWENEIEV 644

  Fly   773 VDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELD 837
            .:::|.:.|.||||||||||::...:|||||.|:.||.|:....:.||||||.|....|....|.
Zfish   645 YELQKGDSGLGFSILDYQDPVNPGRTVIVIRSLVPGGLADRDGRLLPGDRLMFVNQTDLSHASLA 709

  Fly   838 EAVSILKAMPPGLTRLGICRPLSASD 863
            :||.:||:...|..|:|:.:||..:|
Zfish   710 QAVHVLKSTALGTVRIGVTKPLPEND 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	40/71 (56%)
		PDZ	307..393	CDD:214570	12/85 (14%)
		PDZ_signaling	605..680	CDD:238492	37/74 (50%)
		PDZ	773..858	CDD:214570	37/84 (44%)
si:dkey-92j12.5	XP_021332028.1	L27_2	3..58	CDD:312549
		PDZ	137..220	CDD:214570
		PDZ	231..312	CDD:214570	42/80 (53%)
		PDZ_signaling	509..577	CDD:238492	37/76 (49%)
		PDZ_signaling	646..727	CDD:238492	36/80 (45%)
		PDZ	782..852	CDD:214570
		PDZ_signaling	993..1084	CDD:238492
		PDZ_signaling	1210..1286	CDD:238492
		MPDZ_u10	1367..1424	CDD:318804
		PDZ_signaling	1427..1506	CDD:238492
		PDZ_signaling	1531..1612	CDD:238492
		PDZ_signaling	1649..1729	CDD:238492
		PDZ_signaling	1771..1853	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9103
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910