DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and grip1

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	1039	Identity:	204/1039 - (19%)
Similarity:	326/1039 - (31%)	Gaps:	407/1039 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WSQVEVIDLINDGNGLGFILVGG------RSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNL 65
            :..||| .|..:||..||::.||      :|..|.|..:.|||.|:|:|.::.||.||.|..:.|
Zfish   174 FKNVEV-TLHKEGNTFGFVIRGGAHEDRNKSRPVTITTIRPGGPADREGTIKPGDRLLSIDGIRL 237

  Fly    66 RGFSSEQVATVLRQTGAQVRLIV------------------------------------------ 88
            .|.|..:..::|:|.|.:..|::
Zfish   238 HGASHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKSMGSSLGLALSTSMYCNKQ 302

  Fly    89 ------ARP------------------VEPTAIDYQTLA------------CQAPIIP---TKL- 113
                  .:|                  |:.|:::|.|||            .:..|:|   |:|
Zfish   303 VIIIDKVKPASIADRCGALHAGDHILSVDGTSMEYCTLAEATQLLASASEHVKMEILPHHQTRLA 367

  Fly   114 LSDPEEL-----SRHL--------------FQ--------------------NP----SFATAAV 135
            |..||.:     :|.|              :|                    ||    ||:..::
Zfish   368 LKGPEHVKVQRSTRPLPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPSNPPLGSSFSPTSM 432

  Fly   136 AA----------------------------------------AAAAAAAAGSG-----------S 149
            :|                                        |::....||..           |
Zfish   433 SAYSLSSLNMNTLPRTMYPTSPRGTMMRRKLKKKDYKSSMSLASSTVGLAGQVVHTETTEVTLIS 497

  Fly   150 DGDVGGG-------------------------------GVLDVASLVGLVRGGPAEGTELSAVEP 183
            |..:|.|                               |:|.:...:..:.|.|.|.:.|.....
Zfish   498 DSIMGFGIQLQGGVFATETLSSPPLIAYIDPDSPAERCGILQIGDRILSINGIPTEDSTLEETNQ 562

  Fly   184 QPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRP 248
            ....:.:..:...|:..|:|:..:|  ..|..|..:...       |.::|.|...|..|..|..
Zfish   563 LLRDSSITSKVTLEIEFDVAESVIP--SSGTFHVKLPKK-------PGVELGITISSPSSRKPGD 618

  Fly   249 ALQMLPLE-------TQWRCVQDQNRHIETVIADS-----------------KRKLLANEDGGSA 289
            ||.:..::       |....:.|:...|:.:..|:                 |.|:..:||....
Zfish   619 ALIISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSGV 683

  Fly   290 SASGSGSPDSYM------DSPETE---TYVVELHKNVYG--LGITVAGYVCEEEDLSGIFVKSII 343
            ..:||...::.:      |..||.   .|.|||.:  ||  ||||::|   .||....|.:.|:.
Zfish   684 LRAGSVDRNARVLLACVADEQETSGAIIYTVELKR--YGGPLGITISG---TEEPFDPIIISSLT 743

  Fly   344 EGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLR------------ 396
            :|..||.:|.|.|.|||:|::..||.|....:|:.||:.....|.|.:::...
Zfish   744 KGGLAERTGAIHIGDRILAINSNSLKGKPLSEAIHLLQMAGESVTLKIKKQGELPSPKPPSVTGR 808

  Fly   397 ----------GRKYEHLQ-------------------VALTEIKGTSAPSGLDRSQDKDQDQESQ 432
                      |:|...|.                   .|:.....|.||:|...|.......|.:
Zfish   809 LNNLSDLEDDGQKAGKLSDIYSTTIPSVDSAVESWDGSAIDATFSTQAPTGFQASGYSFHSHEWR 873

  Fly   433 LSMP--GS--------------------------PSIATLSWLPPKSLDADSIATEGDEAV---- 465
            .:.|  ||                          ||.:..|.| |..|.:||..|.|.:..
Zfish   874 NAKPSRGSLSPVNSSRQRNNILPDFGIGVDDWDRPSASGASTL-PTGLISDSRFTVGHDGTEPDQ 937

  Fly   466 ----------DAEYVGISGAEDEFIELPSRDTVESNMSHVLD-RSDHSGGLTKDQVPRISPIVPL 519
                      |.|..|.||...|..:.|.|...:.|::.:.. .|..|..|..|..|..|.:
Zfish   938 EENFWSQALEDLETCGQSGILRELEDKPDRLLNKRNLAILATIMSGSSLSLNHDPAPTRSHL--- 999

  Fly   520 TNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPET-------------ERVKDLGDTKTDTD 571
              ||.....:...|         :.:.:||.:.:...|             :.:||:
Zfish  1000 --GRQASFQERGSN---------KPQYSQANRSNTLPTDVGRKAFAMRRMKQEIKDI-------- 1045

  Fly   572 PDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADG 636
                    ..|||.....|.....:..      :..|.|:...| :|.|:      |:.:|...|
Zfish  1046 --------MSPTPVELHKVSLLKDSDL------EDFGFSVSDGV-LEKGV------YVNNIRPGG 1089

  Fly   637 PVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARG--THVPSVINTSQNPE 698
            | ...|.|:|.|.|||:|..:.:......||.::.|...::.||.:|.  :..||.:|...|.|
Zfish  1090 P-AEIGGLKPYDRLLQINHVRTRDFDCCLVVPLIAESGNKLDLVISRNPVSSQPSELNPLSNDE 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	27/125 (22%)
		PDZ	307..393	CDD:214570	33/90 (37%)
		PDZ_signaling	605..680	CDD:238492	20/74 (27%)
		PDZ	773..858	CDD:214570
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492
		PDZ_signaling	178..261	CDD:238492	30/83 (36%)
		PDZ_signaling	276..359	CDD:238492	7/82 (9%)
		PDZ_signaling	490..578	CDD:238492	11/87 (13%)
		PDZ_signaling	591..675	CDD:238492	15/90 (17%)
		PDZ_signaling	711..792	CDD:238492	33/85 (39%)
		PDZ_signaling	1053..1133	CDD:238492	22/93 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900