DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and lnx2a

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	741	Identity:	139/741 - (18%)
Similarity:	218/741 - (29%)	Gaps:	318/741 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STEWSQVEVIDL------------------------INDGNGLGFILVGGRST---GVVIKALTP 41
            |:.|..||.:.|                        .|..:.:|..:|||..|   .|||:.:..
Zfish   240 SSGWDFVETLPLSAEEGCVKLPSLPEGEITTIEVHRTNPYSEMGISIVGGNETPLINVVIQEVYR 304

  Fly    42 GGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQA 106
            .||..|||||..||.:||:..|::..
Zfish   305 DGVIARDGRLLAGDQILQVNNVDISN--------------------------------------- 330

  Fly   107 PIIPTKLLSDPEELSRHLFQNPSFATAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGG 171
              :|            |     :||.:.:|
Zfish   331 --VP------------H-----NFARSTLA----------------------------------- 341

  Fly   172 PAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDI 236
                                                                   |||..|.|.:
Zfish   342 -------------------------------------------------------RPCATLQLTV 351

  Fly   237 VPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYM 301
            :.....|..| ||                                       |:||..|||.|..
Zfish   352 LRERRCSARP-PA---------------------------------------ATASPKGSPASIR 376

  Fly   302 DSPETETYVVELHKNVYG--LGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVD 364
                     :.|||....  |||.:.    ...|.:|:|:..::||..|...|::..|||::||:
Zfish   377 ---------ITLHKRESSEQLGIKLV----RRTDEAGVFILDLLEGGLAAKDGRLCSNDRVLAVN 428

  Fly   365 GRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQ 429
            ...|...|...|.::::.:...|:|.:.|..:.....|....||                  :|.
Zfish   429 EHDLRHGTPELAAQIIQASGERVNLLISRSSKQTMAVHTGSTLT------------------RDI 475

  Fly   430 ESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDA------------EYVGIS---GAEDEF 479
            .|...:|..||.||.|.:|...|...|...:..:.|:.            |.:|::   |...:.
Zfish   476 WSHDHIPPLPSTATPSPVPSLHLARSSTQRDLSQCVNCKEKHITVKKEPHESLGMTVAGGRGSKS 540

  Fly   480 IELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPET 544
            .|||.  .|.|...|        |.|::|...:...::...||:.|.....|
Zfish   541 GELPI--FVTSVQPH--------GCLSRDGRIKRGDVLLSINGQDLTYLSHS------------- 582

  Fly   545 ETAQARKGSKPE-TERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLG 608
            |.....|.|... :.::|.|..|..:   :|.||...:|...|:... :.||:    .|.|..|.
Zfish   583 EAVGTLKSSATSCSVQLKALEVTMVE---EPGLDEELLPPHENDYDA-SWSPS----WVLWLGLP 639

  Fly   609 ISLEGTVDVECGIEKRPH--------------------HYIRSILADGPVGRQGILRPGDELLQV 653
            ..|..:.::   :.:|.|                    .:|::|:...|....|.|:.||.::.|
Zfish   640 SYLHSSHEI---VLRRSHPGSWGFSIVGGYEENHSNQAFFIKTIVLGTPAYYDGRLKCGDMIVAV 701

  Fly   654 NEHKLQGLRHIEVVKILKELPARVKL 679
            |.....|:.|..:|.:|||..:||.|
Zfish   702 NGLSTAGMSHSALVPMLKEQRSRVAL 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	21/74 (28%)
		PDZ	307..393	CDD:214570	23/87 (26%)
		PDZ_signaling	605..680	CDD:238492	22/95 (23%)
		PDZ	773..858	CDD:214570
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	31/233 (13%)
		PDZ_signaling	375..455	CDD:238492	23/92 (25%)
		PDZ_signaling	515..600	CDD:238492	19/107 (18%)
		PDZ_signaling	646..730	CDD:238492	20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000