DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and GRID2IP

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	1060	Identity:	216/1060 - (20%)
Similarity:	343/1060 - (32%)	Gaps:	352/1060 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GN-GLGFILVGGRSTGVV-IKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLRQTG 81
            || ..||.|   |..|.| |:::.||..|: :..|:.||.:|.:..:::|..|.::|.::|:.:|
Human   285 GNKSFGFTL---RGHGPVWIESVLPGSPAD-NAALKSGDRILFLNGLDMRNCSHDKVVSMLQGSG 345

  Fly    82 AQVRLIVARPVEPTAIDYQTLACQAP------------IIPTK--------------LLSDPEEL 120
            |...|:|...:.|.|.|..:|....|            |:|:.              ||:.||..
Human   346 AMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERY 410

  Fly   121 S-----RHLFQNPSFATAAVAAAAAAAAAAGSGSDGDVGGGGVLD-------------------- 160
            .     ...||:.:..|..|                ||  ..|||
Human   411 GVCRALESFFQHRNIDTLIV----------------DV--YPVLDTPAKQVLWQFIYQLLTYEEQ 457

  Fly   161 ------VASLVG--LVRGGPAEGTELSA---VEPQPSAAV---------LQLQQLSELAG----- 200
                  :|..:|  .:...|....:|.:   .||||.:::         |:.|.|.  ||
Human   458 ELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLE--AGLSCGP 520

  Fly   201 -DLADFPLPPIPG----GGGHSMVTDSNAGQRPCPRLDLD------------IVPFSILSPP-PR 247
             :..:.|||.|||    |.|.|:....|.........:|:            .|..|..||| |.
Human   521 SECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPS 585

  Fly   248 PALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANE------DGGSASASGSGS---------- 296
            ||:...|            |.:..|...|:| ||.:.      .||.||.|.|.|
Human   586 PAVTTGP------------RTLSGVSWPSER-LLPSPCYHPLCSGGLASPSSSESHPYASLDSSR 637

  Fly   297 ------------PDS--------------------YMDSPETETYVVELHKNVYGLGITVA-GYV 328
                        |||                    .:.|.:|:.::..|.:.: |..:|:. .::
Human   638 APSPQPGPGPICPDSPPSPDPTRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQL-GPRVTIVDDFL 701

  Fly   329 CEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVD-------GRSL--SGVTN----------- 373
            ..|.|..        |.|..:..|....|:|..|.|       |.||  |.:::
Human   702 TPENDYE--------EMSFHDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPP 758

  Fly   374 ------HQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKG--------------TSAPSG 418
                  |.|....|::|         ..|| ..:.|...||::..              ..||..
Human   759 PPPLPFHDAKPSSRSSD---------GSRG-PAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPM 813

  Fly   419 LDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELP 483
            |.|.....:.:.|.:      |:..|.|             |..|..:....|..|.:.::.:|
Human   814 LSRGLGHRRSETSHM------SVKRLRW-------------EQVENSEGTIWGQLGEDSDYDKL- 858

  Fly   484 SRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSL-ILADDSGNDTDEQCAEPETETA 547
                  |:|...||...|.|  |:.....:....|......: ||:.....:|....|..:...|
Human   859 ------SDMVKYLDLELHFG--TQKPAKPVPGPEPFRKKEVVEILSHKKAYNTSILLAHLKLSPA 915

  Fly   548 QARK---GSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRV----AWK 605
            :.|:   ..:|.......|.......   ||.|..|......|||.:.:.|....|::    .:|
Human   916 ELRQVLMSMEPRRLEPAHLAQLLLFA---PDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYK 977

  Fly   606 SLGISL-------EGTVDV----EC----GIEKRPHHYIRSILADGPVGRQGILRPGDELL--QV 653
            :...||       |.|.::    ||    .:|.:....:..||       :.:|..|:.|.  |.
Human   978 TRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKIL-------EFVLAMGNYLNDGQP 1035

  Fly   654 NEHKLQGLRHIEVVKILKELPARVKLVCARGT--HVPSVINTSQNPEAFETRSLLPGGHQSLQNL 716
            ..:|..|.:    :..|.||.: .|.|..:.|  |:.:...:...||       |.|..|.|..:
Human  1036 KTNKTTGFK----INFLTELNS-TKTVDGKSTFLHILAKSLSQHFPE-------LLGFAQDLPTV 1088

  Fly   717 LSKAQSESSLYTSSTA----TLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEK 777
            ...|:......||..|    |:::...|.         .:.|.|.|:...:.:.|...||....:
Human  1089 PLAAKVNQRALTSDLADLHGTISEIQDAC---------QSISPSSEDKFAMVMSSFLETAQPALR 1144

  Fly   778 TEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPG--DRLMSVGDRLLQGLELDEAV 840
            ...|.      .::.::..|..:...|   ..:...|:|.:.|  ...||..:|.|..|:..|
Human  1145 ALDGL------QREAMEELGKALAFFG---EDSKATTSEAFFGIFAEFMSKFERALSDLQAGE-- 1198

  Fly   841 SILKAMPPGLTRLGICRPLS 860
                    ||...|:..||:
Human  1199 --------GLRSSGMVSPLA 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	23/71 (32%)
		PDZ	307..393	CDD:214570	20/112 (18%)
		PDZ_signaling	605..680	CDD:238492	20/91 (22%)
		PDZ	773..858	CDD:214570	15/86 (17%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269
		PDZ_signaling	278..353	CDD:238492	23/71 (32%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	14/96 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		11/43 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		14/74 (19%)
		FH2	820..1188	CDD:280362	83/435 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900