DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Zasp67

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster

Alignment Length:	772	Identity:	149/772 - (19%)
Similarity:	246/772 - (31%)	Gaps:	268/772 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GFILVGGRSTG---VVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLRQTGAQV 84
            ||.||||....   .|:| :|.|.:|:..| |::.|.:::|.:......:.::...::..:|:..
  Fly    16 GFRLVGGADYDYPLTVVK-VTEGSIADEAG-LRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78

  Fly    85 RLIVARPVEPTAIDYQTL---------ACQAPI-----IPTKLLSDPEELSRHLFQNPS-FATAA 134
            ...|.|..|..|  |:.|         ..::|:     .||..||...|.:......|. |....
  Fly    79 YFGVYRENEEDA--YECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLP 141

  Fly   135 VAAAAAAAAAAGSGSD--------------------GDVGGGGVLDVASLVGLVRGGPAEGTELS 179
            ...|||..||.....|                    |||.|......|...||    |.|...|.
  Fly   142 RELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGL----PVENLYLP 202

  Fly   180 AVEPQPSAAVLQLQQL----SELAGDLAD------------------FPLP-------------- 208
            .:..:|.:|:.:.|::    .|:|..|:.                  ||.|
  Fly   203 DLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNE 267

  Fly   209 -------------------------PIPGGGGHSMVTDSNAGQ--------------------RP 228
                                     |:| ....|:..:..|..                    :|
  Fly   268 EVTKTKLEKDKENRQWSTFLQRPNRPVP-KSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKP 331

  Fly   229 CP----------RLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVI-------ADS 276
            .|          :.:.:.||..::.|.|.|.....||.|... |.:..:..||.:       :|:
  Fly   332 APKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSE-VPNLEQLPETELPDEQPEKSDA 395

  Fly   277 KRKLLANEDGGSASASGSGSPD--SYMDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFV 339
            .:::...|   ....:..||||  ...|.|                    ||.....|.::.:.|
  Fly   396 PKEVCEPE---VVIQTEPGSPDGNEASDGP--------------------AGATPPAEPITPVPV 437

  Fly   340 KS----IIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLR---- 396
            ||    .:|...|:...|:.....:.:....:|..||...|       |::..:.|::..:
  Fly   438 KSEEELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLA-------DLLPTIKLQQQEKQLPQ 495

  Fly   397 -----GRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPS---------------- 440
                 |.: |.::..:|....|...:|      :.:|....:|:.||.:
  Fly   496 IDENSGNE-EQVEEGVTTATNTINTAG------ETEDAGKDISISGSDNPPVGPCESNEDRCDAN 553

  Fly   441 ---IATLSWLPPKSLDADSIATEGDEAVDAEYVGIS-------GAEDEFIELPSRDTVESNMSHV 495
               :|.:|    :|.|.:.:|.:..:.:|.|.....       ..|..|.:....|.:|....|:
  Fly   554 DREVAEIS----RSTDDNRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEEHL 614

  Fly   496 LDRSDHSGGLTKDQVPRIS-----PIVP-------LTNGRSLILADDSGNDTDEQCAEPETETAQ 548
            :.:::          ||.|     |:||       |..||......|:.|  ||..|  ||.:||
  Fly   615 VRKNN----------PRRSKRAFGPLVPSSERPLVLPGGRRWYRPKDAYN--DEFIA--ETLSAQ 665

  Fly   549 AR------------KGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAA 593
            |.            |..||  ||..||..::.....:|.||...:......||:.||
  Fly   666 AELITGSTLGVNFMKYQKP--ERKIDLNRSEVYKYLNPHLDRAPVRGIEVRAPLVAA 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	16/68 (24%)
		PDZ	307..393	CDD:214570	15/89 (17%)
		PDZ_signaling	605..680	CDD:238492
		PDZ	773..858	CDD:214570
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	15/60 (25%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900