DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Lnx2

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	148/672 - (22%)
Similarity:	231/672 - (34%)	Gaps:	220/672 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 SPPPRPALQMLPLETQ--------WRCVQDQNRHIETVIADSKRKLLANEDGG--------SASA 291
            |||....|..:|.|..        |                       .||.|        ||:|
  Rat   175 SPPETDCLGTVPGERNSTPAPLPVW-----------------------TEDPGLDNPAFEESAAA 216

  Fly   292 SGSGSPDSYMDSPETETYVVELHK-NVY-GLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQI 354
            .....|   :..||.|...:|:|: |.| .|||::.|  ..|..|..|.::.:....|....|::
  Rat   217 DSVQQP---LSLPEGEITTIEIHRTNPYIQLGISIVG--GNETPLINIVIQEVYRDGAIARDGRL 276

  Fly   355 QINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGL 419
            ...|:|:.|:...:|.|:::.|..:|......:|||:   ||.|::           |:.|.:..
  Rat   277 LAGDQILQVNNCDISNVSHNYARAVLSQPCSTLHLTV---LRERRF-----------GSRANNHA 327

  Fly   420 DRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPS 484
            |.|..:|:..:..|....|                            ||.:||...
  Rat   328 DGSAPRDEVFQVLLHKRDS----------------------------AEQLGIKLV--------- 355

  Fly   485 RDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQA 549
            |.|.|..: .:||..:  |||.. |..|:|     :|.|.|.:   :|:|..:...|......||
  Rat   356 RRTDEPGV-FILDLLE--GGLAA-QDGRLS-----SNDRVLAI---NGHDLKQGTPELAAHIIQA 408

  Fly   550 RKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTN---EAPVKA---ASPTAASLRVAWKSLG 608
                  ..||| :|...:          ||: |.|:|   ||...:   |.|.:.|...:.|.|
  Rat   409 ------SGERV-NLTIAR----------PGK-PQPSNGSREAGAHSSNHAQPPSHSRPSSHKDL- 454

  Fly   609 ISLEGTVDVEC-----GIEKRPHH-------------------YIRSILADGPVGRQGILRPGDE 649
                 |..|.|     .::|.||.                   ::.|:...|.:.|.|.::.||.
  Rat   455 -----TRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDV 514

  Fly   650 LLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVI----NTSQNPEAFETRSLLPGGH 710
            ||.:|...|..|.|.|.|.:||...|.           |:||    ......||.:.....||.
  Rat   515 LLNINGIDLTNLSHSEAVAMLKASAAS-----------PAVILKALEVQIAEEAAQATEEQPGA- 567

  Fly   711 QSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGL--ALWSCEVTAV 773
                  .|:.:.::|...|....|                           ||  ||.||.  .:
  Rat   568 ------FSENEYDASWSPSWVMWL---------------------------GLPSALHSCH--DI 597

  Fly   774 DIEKTEQG-FGFSIL-DYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLEL 836
            .:.::..| :||||: .|::  :.......|:.::.|..|.....:..||.:::|......|:..
  Rat   598 VLRRSYLGSWGFSIVGGYEE--NHSNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSH 660

  Fly   837 DEAVSILKAMPPGLTRLGICRP 858
            ...|.:||.....:|...:|.|
  Rat   661 SALVPMLKEQRNKVTLTVVCWP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	24/87 (28%)
		PDZ_signaling	605..680	CDD:238492	25/98 (26%)
		PDZ	773..858	CDD:214570	18/86 (21%)
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	24/90 (27%)
		PDZ	335..421	CDD:214570	29/151 (19%)
		PDZ_signaling	462..538	CDD:238492	19/75 (25%)
		PDZ_signaling	595..679	CDD:238492	17/87 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000