DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Dlg5

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	693	Identity:	138/693 - (19%)
Similarity:	211/693 - (30%)	Gaps:	268/693 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GNGLG---FILVGGRSTGVVIKALTPGGVAER---DGRLQLGDHLLQIGEVNLRGFSSEQVATVL 77
            |:|||   ::.|||..:||. .|:..||...|   :.||::..:         ...:|:..:.|.
  Fly  1131 GHGLGIGPYMGVGGGVSGVG-GAIYEGGTFPRKKDNQRLRIPSN---------PSVASKSSSMVK 1185

  Fly    78 RQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAVAAAAAAA 142
            ..:|              :||:..:....|:....:.:...:.:.....:.|...   :..|..|
  Fly  1186 NSSG--------------SIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHN---SYGANIA 1233

  Fly   143 AAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPL 207
            ...|:||...|||||           .||...|:.:    ||....||.
  Fly  1234 GGNGTGSSIGVGGGG-----------GGGSGRGSPM----PQVHVEVLS---------------- 1267

  Fly   208 PPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETV 272
                .|||.|...:||             ||...|.|
  Fly  1268 ----HGGGGSGKRNSN-------------VPADFLCP---------------------------- 1287

  Fly   273 IADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGI 337
             .|.:|                                |.:.|....||||:.   |.... .||
  Fly  1288 -GDLRR--------------------------------VTIDKRDKSLGITIQ---CNNNG-GGI 1315

  Fly   338 FVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLR----NTDIVVHLTLERFLRGR 398
            ||.::.:.|.|..:| :|:.|:::.|.|.::...|...|..:||    :..::|....|:|
  Fly  1316 FVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKF---- 1375

  Fly   399 KYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDE 463
                             || ::.....:.:.||.::..|||:... |..||
  Fly  1376 -----------------PS-IEYEGAHNLEPESPINHSGSPTPRN-SPRPP-------------- 1407

  Fly   464 AVDAEYVGISGAEDEFIELPSRDTVESN-------MSH--VLDRSDHSGGLTKDQVPRISPIVPL 519
                       |.:....||.:....|.       :||  :.|:|      ..|.:...|.|
  Fly  1408 -----------ARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQS------FTDSLENQSDI--- 1452

  Fly   520 TNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTP 584
                      .|..|.....|...|.||.|.              .|..|.:|.|.|.|
  Fly  1453 ----------SSSQDMPSSAATTTTTTASAT--------------STVYDEEPKPSLPP------ 1487

  Fly   585 TNEAPVKAASPTAASLRVAW------KSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGI 643
                  ..||..|.:||...      |:|||.|.|...|  ||      |:..:....|....||
  Fly  1488 ------PPASVPAETLRYVTLHMDKSKNLGIKLFGGNKV--GI------YVHDVAVGSPSDHAGI 1538

  Fly   644 LRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTH 686
             |.||::|:.|...|.|:...:....:.:|...|.::.....|
  Fly  1539 -RKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLH 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	18/75 (24%)
		PDZ	307..393	CDD:214570	23/89 (26%)
		PDZ_signaling	605..680	CDD:238492	22/74 (30%)
		PDZ	773..858	CDD:214570
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	23/115 (20%)
		PDZ_signaling	1497..1576	CDD:238492	24/87 (28%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900