DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and Ush1c

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	803	Identity:	148/803 - (18%)
Similarity:	259/803 - (32%)	Gaps:	280/803 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 ETYVVELHKNVYGLGITVAG---YVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSL 368
            |..:..||..  |||::|.|   :.|      |:|:..:|:|..|::.| :|:.|.||.::|.|:
  Rat    87 EVRLDRLHPE--GLGLSVRGGLEFGC------GLFISHLIKGGQADSVG-LQVGDEIVRINGYSI 142

  Fly   369 SGVTNHQAVELLRNTDIVV----HLTL-------ERFLRGRKYEHLQVALTEIKGTSAPSGLDRS 422
            |..|:.:.:.|:|....|.    |:.|       |..|   |::::...::|..|..  .||...
  Rat   143 SSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPEEPL---KWQYVDQFVSESGGVR--GGLSSP 202

  Fly   423 QDK-DQDQESQLSMPGSPSIAT-------------LSWLPPKSLDADSIATEGDEAVDAEYVG-- 471
            .:: .::::..:|:.||..:..             :|.:.|.||.|:.....||:.|:...:.
  Rat   203 GNRTTKEKKVFISLVGSRGLGCSISSGPIQKPGIFVSNVKPGSLSAEVGLETGDQIVEVNGIDFT 267

  Fly   472 ---------------------ISGAEDEFIELPSRDTVESNMSHVLDRSD---------HSGGLT 506
                                 ::||..|.. :..|:.:|....|.|.|.:         .|..:.
  Rat   268 NLDHKEAVNVLKSSRSLTISIVAGAGRELF-MTDRERLEEARQHELQRQELLMQKRLAMESNKIL 331

  Fly   507 KDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARK---------GSKPETERVKD 562
            ::|       ..:...|...:|..:..:.:....|.|..:.:..|         |||.:....|.
  Rat   332 QEQ-------QEMERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQWEEDWGSKEQLILPKT 389

  Fly   563 LGDTKTDTDPDPDLDP----------GQMPTPTNEA--PVKAASPTAASLRVAWKSLGISLEGTV 615
            :   ..:..|.|...|          |:.||...:|  ..||...:...||...|.|....:...
  Rat   390 I---TAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKKKAKYDSLQDLRKNKKELEFEQKLYK 451

  Fly   616 DVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEH-----------KLQGLRHIEVVKI 669
            :.|..:||.....|..:       .|.:.....|.|:.:|.           :||.:...|  ..
  Rat   452 EKEEMLEKEKQLKINRL-------AQEVSETEREDLEESEKTQYWVERLCQTRLQQISSAE--NE 507

  Fly   670 LKEL--------PARVKLV-----CARGTHV---------------------------------- 687
            :.|:        |:...||     .|.|.|:
  Rat   508 ITEMTTGPPPPPPSVSPLVPPLRRFAGGIHLHTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNP 572

  Fly   688 ------PSVINTSQN--------------------PEAFETRSLLPGG--HQSLQNLLS------ 718
                  |.|:.:|.:                    |.:..|:.|.|..  ..:|:.:|.
  Rat   573 PSKVPAPPVLPSSDHMSSSSSPWVQHTPPPIPIPPPPSIPTQDLTPTRPLPSALEEVLGNHPFRT 637

  Fly   719 ----------KAQSESSLYTSSTA----------TLTDAGAAAGGSGGTA--------------- 748
                      :|.:.|...|||..          |...:.....|.|.:.
  Rat   638 GDPGHPATDWEANTHSGKPTSSPTPERSFPPAPKTFCPSPQPPRGPGVSTISKPVMVHQEHNFVY 702

  Fly   749 GGGARSKSL--ENVSGLALWSCEVTAV--DIEKTEQGF------------------------GFS 785
            ....:|:.|  |.:..:.::.   ||.  |..|.|:||                        |..
  Rat   703 RPAVKSEVLPQEMLKRMVVYQ---TAFRQDFRKYEEGFDPYSMFSPEQIAGKDVRLLRIKKEGSL 764

  Fly   786 ILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSIL-KAMPPG 849
            .|..:..:||....:|:..:..|||||....:..||.:|::..:::....|.||.:.| ||...|
  Rat   765 DLALEGGVDSPVGKVVVSAVYEGGAAERHGGVVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQG 829

  Fly   850 -----LTRLGICRPLSASDSNSN 867
                 |. :.:|.|....|..|:
  Rat   830 GDWIDLV-VAVCPPKEYDDELSS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	28/99 (28%)
		PDZ_signaling	605..680	CDD:238492	15/93 (16%)
		PDZ	773..858	CDD:214570	27/116 (23%)
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492	26/86 (30%)
		PDZ_signaling	209..289	CDD:238492	11/79 (14%)
		Cgr1	<316..>358	CDD:281823	4/48 (8%)
		PDZ_signaling	751..838	CDD:238492	21/87 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900