DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and Pard3b

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	176/805 - (21%)
Similarity:	287/805 - (35%)	Gaps:	221/805 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IDLINDGNGLG------FILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            :::..:|:.||      |..:.||..|:.|:.:......:::|..|..:.:::|..|.|...:..
  Rat   204 VEISGEGDPLGIHVVPFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFA 268

  Fly    72 QVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAP--IIPTKLLSDPEELSR------HLFQNP 128
            |...|.||                       |.::|  ::...|..:.|:..:      ::|.|.
  Rat   269 QAQDVFRQ-----------------------AMKSPSVVLHVLLPQNREQYEKSVIGQLNIFGNN 310

  Fly   129 SFATAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQL- 192
            .         :|:...|...:.|..|       ...|...|....||.|..:.:...|..|.:|
  Rat   311 D---------SASRTKAPPPTRGKAG-------LKAVNPTRANSPEGEESPSPQQSKSPRVPRLG 359

  Fly   193 -----QQLSELAG-------DLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPP 245
                 ..||.|.|       ......|...|.|.|.::||..::...|.|....:|:|.......
  Rat   360 RKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKD 424

  Fly   246 PRPALQMLPLETQWRCVQDQNRHI-----ETVIA--------DSKRKLLANEDGGSASASGSGSP 297
            .|       |::..|.::...|.:     |.::|        ::...::|.::|........|.|
  Rat   425 GR-------LQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEP 482

  Fly   298 DSY---MDSPETETYVVELH-KNVYGLGITVAGYVCEE--EDLSGIFVKSIIEGSAAETSGQIQI 356
            |.|   ::|.|..|..:.|: ....|||:::.|....|  .|| |||:||||.|.||...|::::
  Rat   483 DCYALSLESSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDL-GIFIKSIIHGGAAFKDGRLRM 546

  Fly   357 NDRIVAVDGRSLSGVTNHQAVELLRNT-----------DIVVHLTLERFLRGRK---------YE 401
            ||:::||:|.:|.|.:||:|:|.||.:           .:|:...|||.|....         :|
  Rat   547 NDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRLERPLEEISECGALSRPCFE 611

  Fly   402 HLQVALTEIKGTSA----PSGLDRSQDKDQD--------QESQLSMPGSPSIATLSWLPPKSLD- 453
            :.|.||:..:...:    |.|....|||.:|        .|:::. |..|...:|.|    .|:
  Rat   612 NCQEALSASRRNDSSLLYPCGTYSPQDKRKDLLLPSDGWAENEVP-PSPPPHPSLEW----GLED 671

  Fly   454 ------ADSIATEGDEAVDAEYVGISGAEDEFIEL---PSRDTV--ESNMSHVLDRSDHSGGLTK 507
                  .||.....|:.|:...|...| :.|.|.|   .|.|.|  ||.:..:.||...|.|  |
  Rat   672 FSHSSRVDSTGYFPDQHVNFRIVTPVG-QPESINLKASKSMDLVPDESKVQSLADRRSDSPG--K 733

  Fly   508 DQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGS----KPETERVKDLG---- 564
            |    ..|.:.|....||              ...:|..|:.||..    :|....|:..|
  Rat   734 D----FGPTLGLKKSSSL--------------ESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES 780

  Fly   565 -------------DTKTDTDPDPDLDPGQMPTPTNEAP--------VKAASPTAASLRVAWKSLG 608
                         :.:.|...|.....|........||        |:..:......:...|..|
  Rat   781 FRAAIDKSYDGPEEAEADGLSDKSSHSGHTALNCESAPQGNPELDDVENKAKNVKKTKEKEKKKG 845

  Fly   609 ISLEGTVDVECGIEKRPHHYIRSIL--------------ADGPVGR------QGILRPGDELLQ- 652
               :|.:.|:...:|..|......:              .|..||:      |....||:|.|:
  Rat   846 ---KGKMKVKEKKQKEEHEDTERKMKRKGFGAMLRFGKKKDDKVGKTEQKGTQKSGHPGEEELER 907

  Fly   653 -VNEHKLQGLRHIEVVKILKELPAR 676
             ..|.:..|.:|.|    |:|..||
  Rat   908 MKEERERIGAKHQE----LREKQAR 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	17/77 (22%)
		PDZ	307..393	CDD:214570	35/99 (35%)
		PDZ_signaling	605..680	CDD:238492	22/94 (23%)
		PDZ	773..858	CDD:214570
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492	19/106 (18%)
		PDZ	380..469	CDD:214570	17/95 (18%)
		PDZ_signaling	501..589	CDD:238492	33/88 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900