DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Pdzd7

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001099832.2	Gene:	Pdzd7 / 293996	RGDID:	1309882	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	1011	Identity:	195/1011 - (19%)
Similarity:	298/1011 - (29%)	Gaps:	417/1011 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LGFILVGGR--STGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVL------- 77
            |||.:.||:  ..|:.:..:..||:||.:| :::||.:|....|.....|..|...||
  Rat   222 LGFNIRGGKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIM 285

  Fly    78 ---RQTG---AQVRLI---------------VARPVEPTAIDYQTLACQAPIIPTKLLSD----- 116
               ::||   |...::               ...|...::....:.|..||.....|.||
  Rat   286 LTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSSYASSAPCSSGSLPSDRMDVC 350

  Fly   117 --PEELSRHLFQNPSFATAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASL--------VGLVRGG 171
              ||:.:.   |.|.:..|..|..          ::.|:||..|....|:        ..:...|
  Rat   351 LGPEDPTS---QGPGWGRADTAMQ----------TEPDMGGSRVETWCSVRPTVILRDTAIRSDG 402

  Fly   172 PAEGTEL-SAVEPQPSAAVLQLQQLSELAGDLADFPLPPI------------------------- 210
            |:....| ||:...|..|:  |..||.        |.|||
  Rat   403 PSSTRHLDSALSESPKTAL--LLALSR--------PRPPITRSQSHLTLWEEKKQRKKEKSGSSG 457

  Fly   211 -----------------------PGGGGH--SMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPAL 250
                                   |.|.||  :...||.:..:..|||||:            .|.
  Rat   458 EKGALQRSKTLMNLFFKGGRQGRPAGDGHREAWTLDSRSPTKVRPRLDLE------------KAG 510

  Fly   251 QMLPLE--TQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSG-SPDSYMDSPETETYVVE 312
            .:.|::  ..||..:|:.|         .|.||:...|   |.||.| :.|..|.:.|:...:::
  Rat   511 SVGPVQKFVTWRLRRDRER---------GRALLSARSG---SPSGQGPNVDEQMQAWESRRPLIQ 563

  Fly   313 LHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAV 377
                                                :.:.::..:|.::||. |..|...:...|
  Rat   564 ------------------------------------DLARRLLTDDEVLAVT-RHCSRYVHEGGV 591

  Fly   378 E-----LLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPG 437
            |     ||...|....|.|               |.:|:...||:.|.|.        ..:.||
  Rat   592 EDLVRPLLAILDRPAKLLL---------------LRDIRSVVAPTDLGRF--------DSMVMP- 632

  Fly   438 SPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHS 502
                               :..|..||:.:..||.|...      |:|
  Rat   633 -------------------VEMEAFEALKSRAVGPSALR------PTR----------------- 655

  Fly   503 GGLTKDQVPR---ISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKG--------SKPE 556
                :|..|:   |:| ||.:.|...:|..:|       |:|.|....:.|.|        |.|.
  Rat   656 ----QDTPPKRHLITP-VPDSRGGFYLLPVNS-------CSEDEDGEIRERLGGLKVSLGASAPH 708

  Fly   557 TERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGI 621
            .:.:..|.|...|..   .|..|....|....||....|     |..|
  Rat   709 HKGIPPLQDVPVDAF---SLRRGACAPPPQPPPVAPRPP-----RPNW----------------- 748

  Fly   622 EKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTH 686
                       |...|        |..|..|.|:::..|..                  |:|.
  Rat   749 -----------LLTEP--------PSREDTQQNQNQTPGQS------------------CSRS-- 774

  Fly   687 VPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGG-------- 743
                          .:.|....|.:|......:.:|.....:.|.|.:|.|.:|.|.
  Rat   775 --------------RSHSRSRSGSRSRSRSQGRGKSAGCRRSPSPAPITTATSANGRYHRPRKAR 825

  Fly   744 -------SGGTAGGGARSKSLEN--------VSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPL 793
                   .|..|..|.|.:.|||        .:|.|. :.|:..|.:.|.:|..|.||   ...:
  Rat   826 PLLPRPLDGQVAKVGVRQEPLENGIDQTAEDEAGNAT-TGELRTVTLSKMKQSLGISI---SGGI 886

  Fly   794 DSEGSVIV-IRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVS---------------- 841
            :|:...:| |..:..||||.....:..|..|::|....|:.:....||.
  Rat   887 ESKVQPMVKIEKIFPGGAAFLCRALQAGFELVAVDGESLEQVTHQRAVDTIRRAYRNKAREPMEL 951

  Fly   842 ILKAMPPGLTRLGICRPLS-----------ASDSNS 866
            :::...|||.      |||           |:||:|
  Rat   952 VVRVPGPGLL------PLSSNLRAIKGQGLAADSSS 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	22/96 (23%)
		PDZ	307..393	CDD:214570	12/90 (13%)
		PDZ_signaling	605..680	CDD:238492	7/74 (9%)
		PDZ	773..858	CDD:214570	22/101 (22%)
Pdzd7	NP_001099832.2	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492	19/67 (28%)
		HN_PDZD7_like	555..632	CDD:259824	19/136 (14%)
		PDZ_signaling	866..954	CDD:238492	19/90 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900