DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Mpdz

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	247/884 - (27%)
Similarity:	345/884 - (39%)	Gaps:	350/884 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TEWSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFS 69
            |.|..||.|:|:|||:||||.::||::|||::|.:.|||||::.|||..|||:|:||:.:|.|.|
  Rat   251 THWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 315

  Fly    70 SEQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAA 134
            |||||.||||.|.:|:|::||
  Rat   316 SEQVAQVLRQCGNRVKLMIAR-------------------------------------------- 336

  Fly   135 VAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELA 199
                                                |..|.|      |.||:..:.|
  Rat   337 ------------------------------------GAVEET------PAPSSLGITL------- 352

  Fly   200 GDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQD 264

  Rat   353 ----------------------------------------------------------------- 352

  Fly   265 QNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVC 329
                                 ..|.|.|......|...:.|:||:.|||.|||.|||||:|||:.
  Rat   353 ---------------------SSSTSTSEMRVDASTQKNEESETFDVELTKNVQGLGITIAGYIG 396

  Fly   330 EEE-DLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLER 393
            ::: :.||||||||.:.||.|..|:|||.|:||||||.:|.|.||.||||:||:|...|.|||.|
  Rat   397 DKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMR 461

  Fly   394 FLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIA 458
              :|...|   ..:|..:.|:....|. :::.::|:|| ||:..|.||     ||.:......::
  Rat   462 --KGASQE---AEITSREDTAKDVDLP-AENYEKDEES-LSLKRSTSI-----LPIEEEGYPLLS 514

  Fly   459 TEGDEAVDAE--------YVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISP 515
            ||.:|..|.:        :..|.|...|.:           ::||...|::||
  Rat   515 TELEETEDVQQEAALLTKWQRIMGINYEIV-----------VAHVSKFSENSG------------ 556

  Fly   516 IVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQ 580

  Rat   557 ----------------------------------------------------------------- 556

  Fly   581 MPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILR 645
                                      ||||||.||.         ||:|||:|.:||||..|.|.
  Rat   557 --------------------------LGISLEATVG---------HHFIRSVLPEGPVGHSGKLF 586

  Fly   646 PGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGH 710
            .|||||:||...|.|..|.:||.||||||..|.:||.|.|..|:.::...:.:..:. .|....|
  Rat   587 SGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPTALSEVDSLDIHDL-ELTEKPH 650

  Fly   711 QSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDI 775
            ..|...:..:::|..:...|.   .|..|.                 |..:.||:|...:.|:::
  Rat   651 IDLGEFIGSSETEDPMLAMSD---VDQNAE-----------------EIQTPLAMWEAGIQAIEL 695

  Fly   776 EKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAV 840
            ||..:|.||||||||||:|...:|||||.|:.||.||....::||||||.|.|..|:...|:|||
  Rat   696 EKGSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAV 760

  Fly   841 SILKAMPPGLTRLGICRPLSAS------DSNSNSNIASP 873
            ..||..|.|:.|:|:.:||..|      .:..::.:.||
  Rat   761 EALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDTFLCSP 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	42/71 (59%)
		PDZ	307..393	CDD:214570	53/86 (62%)
		PDZ_signaling	605..680	CDD:238492	39/74 (53%)
		PDZ	773..858	CDD:214570	43/84 (51%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492	46/78 (59%)
		PDZ	374..463	CDD:214570	54/90 (60%)
		PDZ_signaling	552..621	CDD:238492	42/180 (23%)
		PDZ_signaling	693..776	CDD:238492	43/82 (52%)
		PDZ_signaling	993..1063	CDD:238492
		PDZ_signaling	1150..1241	CDD:238492
		PDZ	1348..1433	CDD:214570
		PDZ_signaling	1482..1561	CDD:238492
		MPDZ_u10	1563..1624	CDD:293272
		PDZ	1625..1709	CDD:214570
		PDZ_signaling	1721..1801	CDD:238492
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7377
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810