DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and STXBP4

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_016879899.1	Gene:	STXBP4 / 252983	HGNCID:	19694	Length:	571	Species:	Homo sapiens

Alignment Length:	651	Identity:	130/651 - (19%)
Similarity:	234/651 - (35%)	Gaps:	187/651 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GLGFILVGG--RSTG--VVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLRQTG 81
            |||..::||  |:.|  |.|:.:.|||...:||||:.||.|:.:.:.::.|.|.|:..:::  ||
Human    30 GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII--TG 92

  Fly    82 AQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSD---PEELSRHLFQNPSFATAAVAAAAAAAA 143
            |::         .|.::   .|.:...|..|  ||   ||.||         .|:.:.|:
Human    93 AKL---------STRLE---SAWEIAFIRQK--SDNIQPENLS---------CTSLIEAS----- 129

  Fly   144 AAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPLP 208
                   |:.|                              |.|:.|.|            |..|
Human   130 -------GEYG------------------------------PQASTLSL------------FSSP 145

  Fly   209 P---IPGGGGHSMVTDSNAGQRPCPRLDLDIV-PFSILSPPPR--PALQMLPLETQWRCVQDQNR 267
            |   ||       .|.|.      |:.:.||: ...:||...|  |.:|...::|.:      |:
Human   146 PEILIP-------KTSST------PKTNNDILSSCELLSHTVRLIPGIQSKKIKTGY------NK 191

  Fly   268 HIETVIADSKRKL-LANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEE 331
            .::..|......: |:|.|..||.....|..:....:|.......:|...:..|||...    :|
Human   192 TVQIPITSENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPT----KE 252

  Fly   332 EDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLR 396
            :.      :::.:...|::.|.:...|                 .|::.||            |.
Human   253 QH------QALRQQVQADSKGTVSFGD-----------------FVQVARN------------LF 282

  Fly   397 GRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEG 461
            ..:.:.:.|...||... ..|.|......:.|:..:|......::..::.|..|.|::|....:.
Human   283 CLQLDEVNVGAHEISNI-LDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQL 346

  Fly   462 DEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRI--SPIVPLTNGRS 524
            .|.:...........:|...|.||    .:::....|..|...:..::|.|:  :.|..|    .
Human   347 TEELQNVKQEAKAVVEETRALRSR----IHLAEAAQRQAHGMEMDYEEVIRLLEAKITEL----K 403

  Fly   525 LILADDSGNDTDE-----------QCAEPETETAQARKGSKPETER----VKDLGDTKTD-TDPD 573
            ..|||.|..:.:.           .|...::|  .|||..:..||:    |:.:.:..:| :.|.
Human   404 AQLADYSDQNKESVQDLKKRIMVLDCQLRKSE--MARKTFEASTEKLLHFVEAIQEVFSDNSTPL 466

  Fly   574 PDLDPGQ--MPTPTNEAPV-KAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILAD 635
            .:|...:  :.:.|:..|: :......|:|.:..|.|..|:...:|::|    .|:.:..:..||
Human   467 SNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDC----LPYGWEEAYTAD 527

  Fly   636 G 636
            |
Human   528 G 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	25/71 (35%)
		PDZ	307..393	CDD:214570	11/85 (13%)
		PDZ_signaling	605..680	CDD:238492	9/32 (28%)
		PDZ	773..858	CDD:214570
STXBP4	XP_016879899.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100