DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and LNX2

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_699202.1	Gene:	LNX2 / 222484	HGNCID:	20421	Length:	690	Species:	Homo sapiens

Alignment Length:	431	Identity:	93/431 - (21%)
Similarity:	148/431 - (34%)	Gaps:	150/431 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NDGNGLGFILVGGRST---GVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSEQVATVLR 78
            :.|..||..||  |.|   ||.|..|..||:|.:||||...|.:|.|...:|:..:.|..|.:::
Human   346 DSGEQLGIKLV--RRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQ 408

  Fly    79 QTGAQVRLIVARPVEP-------------------TAIDY-----------QTLACQAPIIPTKL 113
            .:|.:|.|.:|||.:|                   |...|           |.:.||...|..|
Human   409 ASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVK- 472

  Fly   114 LSDPEELSRHLFQNPSFATAAVAAAAAAAAAAGSGS--------------------DGDVGGGGV 158
             .:|.|                  :.....|.|.||                    ||.:..|.|
Human   473 -KEPHE------------------SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDV 518

  Fly   159 LDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSN 223
                 |:.:      .|.:|:.:....:.|:|:....|
Human   519 -----LLNI------NGIDLTNLSHSEAVAMLKASAAS--------------------------- 545

  Fly   224 AGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGS 288
                                    ||:.:..||.|  .|::..::.|    :.......||
Human   546 ------------------------PAVALKALEVQ--IVEEATQNAE----EQPSTFSENE---- 576

  Fly   289 ASASGSGSPDSYMDSPET--ETYVVELHKNVYG-LGITVAGYVCEEEDLSGIFVKSIIEGSAAET 350
            ..||.|.|...::..|.|  ..:.:.|.::..| .|.::.|...|.......|:|:|:.|:.|..
Human   577 YDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641

  Fly   351 SGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTL 391
            .|:::..|.||||:|.|..|:::...|.:|:.....|.||:
Human   642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	27/74 (36%)
		PDZ	307..393	CDD:214570	24/86 (28%)
		PDZ_signaling	605..680	CDD:238492
		PDZ	773..858	CDD:214570
LNX2	NP_699202.1	mRING-HC-C3HC3D_LNX2	45..89	CDD:319694
		modified RING-HC finger (C3HC3D-type)	50..87	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..224
		NPXY motif	208..211
		PDZ	230..316	CDD:214570
		PDZ	336..422	CDD:214570	29/77 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..455		6/36 (17%)
		PDZ_signaling	466..542	CDD:238492	17/106 (16%)
		PDZ_signaling	599..683	CDD:238492	24/84 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000