DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and T19B10.5

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_505852.3	Gene:	T19B10.5 / 179553	WormBaseID:	WBGene00011833	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	129/556 - (23%)
Similarity:	211/556 - (37%)	Gaps:	128/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 NRHIETVIADS---KRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGY 327
            |:...|:| ||   |||:   ||.|:..|...    .:::..|.:..|.....::.|||..:.|.
Worm    90 NKDKMTMI-DSFKLKRKM---EDSGTQKAYSM----EFLNEVEGKVGVQLRGVDIGGLGFNIQGN 146

  Fly   328 VCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLS----GVTNHQAVELLR-NTDIVV 387
            :.|     |||||.||....||..|.|.:.|:|     :||:    .:....||.||. ::...|
Worm   147 MNE-----GIFVKEIISKGIAEQCGNILVGDKI-----KSLTINFENMVYEDAVTLLSYSSPYKV 201

  Fly   388 HLTLERFL------------RGRKYEHL--QVALTEIK----GT-SAPSGLDRSQDK--DQDQES 431
            .|.|||.|            :..:|..|  ...||.:.    || |.|:.:..:..:  ..|.:.
Worm   202 KLELERKLSDSASVSDSDDDKEMRYHPLFRSNTLTHVHFNPLGTISTPTSIATTPQRCTSTDSKQ 266

  Fly   432 QLSMPGSPSIATLSWLPPKS---LDADSIATEGDEA-VDAEYVGISGAEDEFIELPSRDTVESNM 492
            :.::|....|     :.|.|   .|.:|.|.:.|.: :|:...|..|..| ..|..:.|..:..:
Worm   267 KHALPPQREI-----IEPDSTTCADDNSQARDADNSRMDSSDYGSDGISD-CRESTASDGTQKTL 325

  Fly   493 SHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAE---------------- 541
            |..::.:|    :..|:|...:| .||   |.|           |||.|
Worm   326 SDRIEVTD----IIFDKVKSPTP-PPL---RKL-----------EQCTELPPKPRKMVSRSPSPV 371

  Fly   542 --PETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAW 604
              |......:|..|..::::|:|  .|:|     ..|.....||.| |.|:....|..:|:.|.
Worm   372 NKPPPSPKVSRATSPKKSQQVED--STQT-----TQLSAETRPTQT-EKPIAPVPPPISSIPVR- 427

  Fly   605 KSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVK- 668
            |.:....:.....:..:||        |:...||..:.....|.|:.:....::.  :..:.:|
Worm   428 KEMETQTKTPPPDQTVVEK--------IVEIAPVEIKEDDSKGPEITEARISRIP--KRSDSIKT 482

  Fly   669 --ILKELPARVKLVCAR------GTHVPSVINTSQNPEAFETR--SLLPGGHQSLQNLLSKAQSE 723
              |.::||:..|.|..|      ..:|.|.:...:.....:||  |..|..|.|    .....|.
Worm   483 PVIERKLPSLPKSVTQRSHSADKNDNVWSRLYQEKKGNLRKTRDVSSPPTAHTS----GIPTPSR 543

  Fly   724 SSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLEN 759
            ||:.::.|||:....:......||.....|.:.:.|
Worm   544 SSITSTVTATVGKTPSTDNEKYGTLTREKRDRLMAN 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	28/90 (31%)
		PDZ_signaling	605..680	CDD:238492	13/77 (17%)
		PDZ	773..858	CDD:214570
T19B10.5	NP_505852.3	PDZ	137..208	CDD:214570	28/80 (35%)
T19B10.5	NP_505852.3	PTZ00449	<340..483	CDD:185628	34/176 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900