DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and frm-5.1

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001255216.1	Gene:	frm-5.1 / 176822	WormBaseID:	WBGene00001492	Length:	1565	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	100/491 - (20%)
Similarity:	170/491 - (34%)	Gaps:	161/491 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QVEVIDLINDGNGLGFILVGGRST---GVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSS 70
            |.:::.:.:..||||..||.|...   ||.:|.:...|...:.| :.:||.::|:|..::.|...
Worm  1126 QFDILLVKDPANGLGLTLVDGNLNGVPGVYVKLVADNGAGMKAG-VCVGDRIVQVGTESMEGHDR 1189

  Fly    71 EQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAV 135
            .....::|:.|.:|.:::||      :|             .|:...:::|..:.
Worm  1190 LHAVELVRRCGQRVPMVIAR------LD-------------GLIRHQKDVSAEML---------- 1225

  Fly   136 AAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAG 200
              |:|....:.:.|.||               :...|......|...|.|..|..:.|:.....|
Worm  1226 --ASAGRKKSFTSSSGD---------------LLNAPNRTNGQSRTPPAPRKAANRRQRAVSDFG 1273

  Fly   201 DLADFPLPPIPG---------GGGHSMVTDSNAGQRPCPRLDL------DIVPFSI---LSPPPR 247
            .:.| .||.:.|         .|.|...:|...|:...|...:      |.:..||   ..|.|.
Worm  1274 AIGD-ALPTLDGDNLINIKAISGLHLDESDEEKGEYRLPTTSMYAFDRDDDLQASIKESKKPAPE 1337

  Fly   248 PALQMLPLETQWRCVQDQNRHI------ETV--------IADSKR----KLLANEDG--GSASAS 292
            |....|   .::|..:..|..|      |.|        |.:.||    :|..||:|  |...||
Worm  1338 PKSGEL---RKYRYARRSNLEIAEEIEEEAVESSDDDGQIDEGKRVIDVELDRNENGSLGVQIAS 1399

  Fly   293 GSG---------------------------------------------------------SPDSY 300
            .||                                                         .|.:|
Worm  1400 LSGRVCIKQLTSEPAISHPDIRVGDVLLYVNGIAVEGKVHQEVVAMLRGGGDRVVLGVQRPPPAY 1464

  Fly   301 MDSPETET--------YVVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQIN 357
            .|.....:        .|:.|.|.:..||:::|.....:    |||:::|.:.|||.:.|.:::.
Worm  1465 SDQHHASSTSASAPLISVMLLKKPMATLGLSLAKRTMSD----GIFIRNIAQDSAASSEGTLRVG 1525

  Fly   358 DRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLER 393
            ||:|::||..:.|.|....:|.|:.....|.:|:.|
Worm  1526 DRLVSLDGEPVDGFTPATILEKLKLVQGPVQITVTR 1561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	20/74 (27%)
		PDZ	307..393	CDD:214570	25/93 (27%)
		PDZ_signaling	605..680	CDD:238492
		PDZ	773..858	CDD:214570
frm-5.1	NP_001255216.1	PKc_like	9..164	CDD:304357
		B41	686..891	CDD:214604
		FERM_N	689..751	CDD:286467
		FERM_M	781..891	CDD:278785
		PH-like	887..1016	CDD:302622
		PDZ_signaling	1127..1208	CDD:238492	20/81 (25%)
		PDZ_signaling	1380..1458	CDD:238492	9/77 (12%)
		PDZ_signaling	1479..1559	CDD:238492	24/83 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100