DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Mpdz

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	880	Identity:	244/880 - (27%)
Similarity:	345/880 - (39%)	Gaps:	345/880 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            |..||.|:|:|||:||||.::||::|||::|.:.|||||::.|||..|||:|:||:.:|.|.|||
Mouse   253 WQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 317

  Fly    72 QVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAVA 136
            |||.||||.|.:|:|::||
Mouse   318 QVAQVLRQCGNRVKLMIAR---------------------------------------------- 336

  Fly   137 AAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGD 201
                                                      .|||..|:::.|
Mouse   337 ------------------------------------------GAVEETPASSSL----------- 348

  Fly   202 LADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQN 266

Mouse   349 ----------------------------------------------------------------- 348

  Fly   267 RHIETVIADSKRKLLANEDGGSASASGSGSPDSYMD-----SPETETYVVELHKNVYGLGITVAG 326
                               |.:.|:|.|.:.:..:|     :.|:||:.|||.|||.|||||:||
Mouse   349 -------------------GITLSSSTSSTSEMRVDASTQKNDESETFDVELTKNVQGLGITIAG 394

  Fly   327 YVCEEE-DLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLT 390
            |:.::: :.||||||||.:.||.|..|:|||.|:|:||||.:|.|.||.||||:||:|...|.||
Mouse   395 YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVRLT 459

  Fly   391 LERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDAD 455
            |.|                 ||.|              ||::|:
Mouse   460 LMR-----------------KGAS--------------QEAELT--------------------- 472

  Fly   456 SIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPL- 519
               :.||.|.|             ::||:.:..:...|..|.|:              :.|:|:
Mouse   473 ---SRGDTAKD-------------VDLPAENCEKDEESLSLKRN--------------TSILPIE 507

  Fly   520 TNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTP 584
            ..|..|:.|:           ..|.|..|.......:.:|:..:
Mouse   508 EEGFPLLSAE-----------LEEAEDVQQEAALLTKWQRIMGI--------------------- 540

  Fly   585 TNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDE 649
            ..|..|...|..:.:     ..||||||.||.         ||:|||:|.:||||..|.|..|||
Mouse   541 NYEIVVAHVSKFSEN-----SGLGISLEATVG---------HHFIRSVLPEGPVGHSGKLFSGDE 591

  Fly   650 LLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQ 714
            ||:||...|.|..|.:||.||||||..|.:||.|.| ||.:..:..:........|....|..|.
Mouse   592 LLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRT-VPPIALSEMDSLDINDLELTEKPHIDLG 655

  Fly   715 NLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEKTE 779
            ..:..:::|..:...|.   .|..|.                 |..:.||:|.....::::||..
Mouse   656 EFIGSSETEDPMLAMSD---VDQNAE-----------------EIQTPLAMWEAGGQSIELEKGS 700

  Fly   780 QGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSILK 844
            :|.||||||||||:|...:|||||.|:.||.||....::||||||.|.|..|:...|:|||..||
Mouse   701 RGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALK 765

  Fly   845 AMPPGLTRLGICRPLSAS------DSNSNSNIASP 873
            ..|.|:.|:|:.:||..|      .:..::.:.||
Mouse   766 GAPSGMVRIGVAKPLPLSPEEGYVSAKEDAFLCSP 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	42/71 (59%)
		PDZ	307..393	CDD:214570	52/86 (60%)
		PDZ_signaling	605..680	CDD:238492	39/74 (53%)
		PDZ	773..858	CDD:214570	43/84 (51%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492	46/78 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372		6/118 (5%)
		PDZ	375..464	CDD:214570	53/105 (50%)
		PDZ_signaling	553..622	CDD:238492	39/82 (48%)
		PDZ_signaling	694..777	CDD:238492	43/82 (52%)
		PDZ_signaling	994..1064	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144
		PDZ_signaling	1151..1242	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313
		PDZ	1349..1434	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473
		PDZ_signaling	1483..1563	CDD:238492
		MPDZ_u10	1564..1625	CDD:293272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611
		PDZ	1626..1710	CDD:214570
		PDZ_signaling	1722..1802	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7599
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.770