DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and mpz-1

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001364655.1	Gene:	mpz-1 / 174657	WormBaseID:	WBGene00003404	Length:	2422	Species:	Caenorhabditis elegans

Alignment Length:	923	Identity:	272/923 - (29%)
Similarity:	386/923 - (41%)	Gaps:	265/923 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLSTEWSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNL 65
            ||||.:|:|||||.|..:..||||.:|||.|||||:|.:.||..|::|||||.|||:||||.:|.
Worm   239 MVLSGDWTQVEVIHLNTETGGLGFGIVGGTSTGVVVKTILPGSPADKDGRLQPGDHILQIGNINS 303

  Fly    66 RGFSSEQVATVLRQTGAQVRLIVARPV----EPTAIDYQ---TLACQAPIIPTKLLSDPEELSRH 123
            .|.||:||||:||.....|.:||.||:    :|  ||..   |||.:|.:..|.|   .|.|.|.
Worm   304 HGMSSQQVATILRHQHPTVDMIVGRPIAYADKP--IDTPECFTLATKAALCATTL---EEALQRQ 363

  Fly   124 LFQNPSFATAAVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAA 188
            :      ||:..:..|.......|.|            .|.|.:     .|..|....||:|:.:
Worm   364 M------ATSVPSTTANQTPNTLSPS------------ISCVPI-----EEEKEEKEPEPEPTTS 405

  Fly   189 VLQLQQLSELAGDLADF--PLPPIP---------------------GGGGHSMVTDSNAGQRPCP 230
            ..|..:::....|..|.  |....|                     ||||.....:.:  |....
Worm   406 KEQPIKITTYLPDTIDIRKPCDCAPNYNRRDKRKSSCDDGEHGDGDGGGGCKKTKEDH--QEEEN 468

  Fly   231 RLD-LDIVPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGS 294
            .:| .|.:...:.||         .:||.   ..|:|..:.:|...|||    |.:..::..|..
Worm   469 EIDSKDELGEMVRSP---------TVETG---QSDENSVVTSVSRSSKR----NSNSITSRISLK 517

  Fly   295 GSPDSYM--------DSPETETYVVELHKN-VYGLGITVAGYVCEEEDLSGIFVKSIIEGSAAET 350
            ...:..:        :|.:.|...|.||:: ..||||||||||.::|::.||||||::..|||.:
Worm   518 SLQEMALTVFLRENWESTKFELIDVALHRDPALGLGITVAGYVHKKEEIGGIFVKSLVPRSAASS 582

  Fly   351 SGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSA 415
            ||.|:::|.|:.|:|.:|..:::..:|..|..:...|.|.|.||                 ..|:
Worm   583 SGVIKVHDLILEVNGTTLEHMSHADSVRTLVKSGDQVKLKLVRF-----------------PLSS 630

  Fly   416 PSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFI 480
            |........:.|:.|:|:                               :|             :
Worm   631 PQAQCLKMLQQQETETQV-------------------------------ID-------------V 651

  Fly   481 ELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETE 545
            :|.:.|.|:...|.:           .|.:..|:.:|
Worm   652 KLSNPDLVKEWKSRI-----------GDDIEIIAAVV---------------------------- 677

  Fly   546 TAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGIS 610
                    ||:.:.|                |.|                           ||||
Worm   678 --------KPDRQSV----------------DGG---------------------------LGIS 691

  Fly   611 LEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKEL-- 673
            |||||||..|.:..|||||.||..||||.:..:|:.||||||||...|.|..|:.|.:.|...
Worm   692 LEGTVDVLNGAQLCPHHYIESIRQDGPVAKTKVLQAGDELLQVNHSPLYGESHVTVRQALTRAVH 756

  Fly   674 -PARVKLVCARGTHVPSVINTSQNPEAFETRSL---LPGGHQSL---QNLLSKAQSESSLYTSST 731
             .|.|.|:.||         .||:...||..:.   ||.....|   |..:.||:|:..| ||:.
Worm   757 SGAPVTLIVAR---------RSQHLHVFEPTTYEKQLPLSFPFLAANQETVVKAKSDIDL-TSTR 811

  Fly   732 ATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSE 796
            |..|.........       .|||||||..|||:|:|....:.:.|..:|.||||:||:||...:
Worm   812 AETTHLLQRVSRR-------LRSKSLENFHGLAVWNCVPLVIHLCKDSRGLGFSIVDYKDPTHRD 869

  Fly   797 GSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSILKAMPPGLTRLGICRPLSA 861
            .||||::.|:.||.|:|...:.|||||:.|.:..|....|:.||::|||...|..|||:.:|:..
Worm   870 ESVIVVQSLVPGGVAQADGRVVPGDRLLFVNNHDLSNSSLERAVAVLKAARMGPVRLGLAKPIPV 934

  Fly   862 SDSNSNSNIASPL 874
            ..|...|:  |||
Worm   935 DQSQFTSH--SPL 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	40/71 (56%)
		PDZ	307..393	CDD:214570	37/86 (43%)
		PDZ_signaling	605..680	CDD:238492	39/77 (51%)
		PDZ	773..858	CDD:214570	36/84 (43%)
mpz-1	NP_001364655.1	PDZ_signaling	<271..326	CDD:238492	30/54 (56%)
		PDZ_signaling	539..624	CDD:238492	35/84 (42%)
		PDZ_signaling	685..766	CDD:238492	42/107 (39%)
		PDZ_signaling	843..926	CDD:238492	33/82 (40%)
		PDZ	1050..1124	CDD:214570
		PDZ_signaling	1475..1569	CDD:238492
		PDZ	1827..1912	CDD:214570
		PDZ	1988..2073	CDD:214570
		PDZ_signaling	2089..2169	CDD:238492
		PDZ_signaling	2341..2414	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5042
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.000