DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Grip2

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	211/989 - (21%)
Similarity:	323/989 - (32%)	Gaps:	402/989 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IDLINDGNGLGFILVGG------RSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            :.|..:||..||:|.||      :|..:|:..:.|||.|:|:|.|::||.||.|..:.|.|.|..
  Rat   154 VSLYKEGNSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHA 218

  Fly    72 QVATVLRQTG----AQVRLIVARP----------------------------------------- 91
            .....|:|..    .||...||.|
  Rat   219 TAIATLQQCSHEALFQVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAITIDR 283

  Fly    92 VEPT----------------AIDYQTLACQAPIIPTKLLS------------------------- 115
            ::|.                |||..:....:.:..||||:
  Rat   284 IKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKPPEA 348

  Fly   116 ------------DP----------------------EELSRHL----FQNPSFATAAVAAAAAA- 141
                        ||                      ::.||.:    |.:|:...|...|.|:.
  Rat   349 VRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPCANASTL 413

  Fly   142 -------AAAAG-------------SGSDGDVGGGGVL------------DVASLVGL-VRGGPA 173
                   ...||             |.:...||.||.:            |..|..|| ::||..
  Rat   414 PRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIF 478

  Fly   174 EGTELSA------VEPQPSA----------------------------------AVLQLQQLSEL 198
            ....||:      :||...|                                  |.|..:.:.|:
  Rat   479 ATETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEI 543

  Fly   199 AGDLADFPLP-------PIPGGGGHSM-VTDSNAG-QRPCPRLDLDIVPFSI------LSP---- 244
            ..|:|:..:|       .:|...|..: :|.|:|. :|..|.:..||...|:      |.|
  Rat   544 EFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKL 608

  Fly   245 -----------PPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPD 298
                       |...|:|:|             |..|.::   |.|:..:||......| ||:
  Rat   609 LAIDNIRLDHCPMEYAVQIL-------------RQCEDLV---KLKIRKDEDNSDEQES-SGA-- 654

  Fly   299 SYMDSPETETYVVELHKNVYG--LGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIV 361
                    .:|.|||.:  ||  ||||::|   .||....|.:..:.:...||.:|.|.:.|||:
  Rat   655 --------VSYTVELKR--YGGPLGITISG---TEEPFDPIIISGLTKRGLAERTGAIHVGDRIL 706

  Fly   362 AVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKD 426
            |::..||.|....:|:.||:.....|.|.:::.|.       :..|....|:     |..:.|.|
  Rat   707 AINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD-------RPLLPRQSGS-----LSEASDVD 759

  Fly   427 QDQESQLS--------MPGSPSI--ATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIE 481
            :|....|.        .|..||:  |..||        .|.||||.       .|.||:....:.
  Rat   760 EDPPEALKGGLLTTHFSPAVPSVDSAVESW--------GSSATEGG-------FGGSGSYTPQVA 809

  Fly   482 LPSRDTVESNMSHVLD--------RSDHSGGLTKDQVPRIS------PIVPLTN----------- 521
            :.|....|...|.:..        |:.::.|.|.:..|...      |:.|...
  Rat   810 VRSVTPQEWRSSRLKSSPPPLEPRRTSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVL 874

  Fly   522 GRSLILADDSGNDTDEQCAEPE----------TETAQA-----RKGSKPETERVKDLGDTKTDTD 571
            |.:|        :..|.|.:.|          |.|.|:     |.||:| ..|.:::|     |.
  Rat   875 GEAL--------EDLESCGQSELLRELEASIMTGTVQSVAVDGRPGSRP-WRRSREVG-----TS 925

  Fly   572 PDPDLDPGQMPTP-------TNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYI 629
            |: ||....:|||       .::.||:             ...|.|:...: :|.|:      |:
  Rat   926 PE-DLQELLLPTPLEMHRVTLHKDPVR-------------NDFGFSVSDGL-LEKGV------YV 969

  Fly   630 RSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTS 694
            .::..||| .:.|.|:|.|.|||||..:.:.......|.:|.|....::||            .|
  Rat   970 HTVRIDGP-AQHGGLQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILELV------------VS 1021

  Fly   695 QNPEAFETRSLLPG 708
            :||.|...|:  ||
  Rat  1022 RNPLAQSRRT--PG 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	28/81 (35%)
		PDZ	307..393	CDD:214570	30/87 (34%)
		PDZ_signaling	605..680	CDD:238492	20/74 (27%)
		PDZ	773..858	CDD:214570
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492	28/81 (35%)
		PDZ_signaling	251..334	CDD:238492	8/82 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		13/78 (17%)
		PDZ_signaling	456..544	CDD:238492	14/87 (16%)
		PDZ_signaling	557..640	CDD:238492	20/98 (20%)
		PDZ_signaling	657..737	CDD:238492	30/84 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		19/91 (21%)
		PDZ_signaling	941..1020	CDD:238492	24/111 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900