Protein Alignment CG15803 and FRMPD2

DIOPT Version :10

• Sequence 1: NP_001287388.1
• Gene: CG15803 / 42206
• FlyBaseID: FBgn0038606
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: XP_054220869.1
• Gene: FRMPD2 / 143162
• HGNCID: 28572
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 165/779 - (21%)
• Similarity: 266/779 - (34%)
• Gaps: 267/779 - (34%)

  Fly   122 RHLFQNPSFATAAVAAAAAAA-----AAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAV 181
            :|.|...|..|:.......:|     |..|||....|    :.|....|.:....||....
Human   613 KHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHV----LFDHDKFVQMANLSPAHQAR---- 669

  Fly   182 EPQPSAAVLQLQQLSELAGDLADFPLPPIPGG-----------GGHSMVTDSNAGQRPCP-RLDL 234
                |..::.:|:||....:|....|....||           .|.........|:.||. |..|
Human   670 ----SKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQL 730

  Fly   235 DI-------VPFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSK---RKLLANEDGGSA 289
            ..       :.:..||.||                      ::::.|.||   ||
Human   731 KSACVIQKPMTWDSLSGPP----------------------VQSMHAGSKNNRRK---------- 763

  Fly   290 SASGSGSPDSYMDSPETETYVVELHKNVY-GLGITVAGYVCEEEDLS-----GIFVKSIIEGSAA 348
                     |::..|..|...|.|.::.: |.     |:|..|.:.|     |||:.|||.|..|
Human   764 ---------SFIAEPGREIVRVTLKRDPHRGF-----GFVINEGEYSGQADPGIFISSIIPGGPA 814

  Fly   349 ETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGT 413
            |.:..|:...:|:|::..||.|.|.:.||.:::|:.                :::::.:::.||.
Human   815 EKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSP----------------DNIELIISQSKGV 863

  Fly   414 SAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDE 478
            ..         .:.|:|.                       :|.|..|..:.|....|..|:...
Human   864 GG---------NNPDEEK-----------------------NSTANSGVSSTDILSFGYQGSLLS 896

  Fly   479 FIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRIS---PIVPLTNGRSLILADDSGNDTDEQC- 539
            ..:...|:|.|.:|:.|           :..|||:.   ..:||....|             .|
Human   897 HTQDQDRNTEELDMAGV-----------QSLVPRLRHQLSFLPLKGAGS-------------SCP 937

  Fly   540 -AEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVA 603
             :.||...     |.....|.||:.|
Human   938 PSPPEISA-----GEIYFVELVKEDG--------------------------------------- 958

  Fly   604 WKSLGISLEGTVDVEC---GIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIE 665
              :||.|:.|.::...   ||      |::||:..||..::|.:..||.||||:...|.||.|.:
Human   959 --TLGFSVTGGINTSVPYGGI------YVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQ 1015

  Fly   666 VVKILKELPARV-KLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTS 729
            .|:.||. |.:| :||..|  .||.  :|.|.|.|.::.    |..::..:|::.....    .|
Human  1016 AVQCLKG-PGQVARLVLER--RVPR--STQQCPSANDSM----GDERTAVSLVTALPGR----PS 1067

  Fly   730 STATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEKTEQGFGFSILDYQDPLD 794
            |..::||            |.....|..:|.:||                 ||.|..::.:....
Human  1068 SCVSVTD------------GPKFEVKLKKNANGL-----------------GFSFVQMEKESCSH 1103

  Fly   795 SEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSILKAMPPGLTRLGICRP 858
            .:..::.|:.|..|..||....|..||.:::|..|..:||...|.:.:|:..|..:|.| :|||
Human  1104 LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLL-LCRP 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ4_MUPP1-like	592..683	CDD:467156	29/94 (31%)
		PDZ5_MUPP1-like	763..859	CDD:467157	24/96 (25%)
		PDZ2_MUPP1-like	11..90	CDD:467155
		PDZ3_MUPP1-like	307..393	CDD:467253	27/91 (30%)
FRMPD2	XP_054220869.1	KIND	15..197	CDD:214801
		FERM_F1_FRMPD2	341..434	CDD:340716
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008	9/33 (27%)
		PDZ_canonical	772..863	CDD:483948	28/111 (25%)
		PDZ2-PTPN13_FRMPD2-like	947..1033	CDD:467254	33/133 (25%)
		PDZ3_PTPN13_FRMPD2-like	1078..1166	CDD:467181	25/105 (24%)