DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and Lnx2

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	611	Identity:	131/611 - (21%)
Similarity:	214/611 - (35%)	Gaps:	180/611 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 SASASGSGSPDSYMDSPETETYVVELHK-NVY-GLGITVAGYVCEEEDLSGIFVKSIIEGSAAET 350
            ||:|.....|   :..||.|...:|:|: |.| .|||::.|  ..|..|..|.::.:........
Mouse   213 SAAADSVQQP---LSLPEGEITTIEIHRSNPYIQLGISIVG--GNETPLINIVIQEVYRDGVIAR 272

  Fly   351 SGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTEIKGTSA 415
            .|::...|:|:.|:...:|.|:::.|..:|......:.||:   ||.|::           |:.|
Mouse   273 DGRLLAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTV---LRERRF-----------GSRA 323

  Fly   416 PSGLDRSQDKDQ---------DQESQLSM-----PGSPSIATLSWLPPKSLDADSIATEGDEAVD 466
            .|..|.|..:|:         |...||.:     ...|.:..|..|            ||..|
Mouse   324 NSHADGSAPRDEVFQVLLHKRDSTEQLGIKLVRRTDEPGVFILDLL------------EGGLA-- 374

  Fly   467 AEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILA--- 528
                    |:|.  .|.|.|.|.:...|.|          |...|.::..:...:|..:.|.
Mouse   375 --------AQDG--RLNSNDRVLAINGHDL----------KHGTPELAAQIIQASGERVNLTIAR 419

  Fly   529 ---DDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPV 590
               ....|.:.|..|...:..||....|:|.:.  |||  |:..|..:..:...:.|
Mouse   420 PGKPQPSNGSREAGAHSSSNHAQPPSHSRPGSH--KDL--TRCVTCQEKHITVKKEP-------- 472

  Fly   591 KAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVNE 655
                         .:|||:::.|....:.|  :.| .::.|:...|.:.|.|.::.||.||.:|.
Mouse   473 -------------HESLGMTVAGGRGSKSG--ELP-IFVTSVPPHGCLARDGRIKRGDVLLNING 521

  Fly   656 HKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVI--------------NTSQNPEAFETRSLL 706
            ..|..|.|.|.|.:||...|.           |:||              .|.:.|.||
Mouse   522 IDLTNLSHSEAVAMLKASAAS-----------PAVILKALEVQIAEEAAQATEEQPSAF------ 569

  Fly   707 PGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGL--ALWSCE 769
                       |:.:.::|...|....|                           ||  ||.||.
Mouse   570 -----------SENEYDASWSPSWVMWL---------------------------GLPSALHSCH 596

  Fly   770 VTAVDIEKTEQG-FGFSIL-DYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQ 832
              .:.:.::..| :||||: .|::  :.......|:.::.|..|.....:..||.:::|......
Mouse   597 --DIVLRRSYLGSWGFSIVGGYEE--NHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 657

  Fly   833 GLELDEAVSILKAMPPGLTRLGICRP 858
            |:.....|.:||.....:|...||.|
Mouse   658 GMSHSALVPMLKEQRNKVTLTVICWP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492
		PDZ	307..393	CDD:214570	22/87 (25%)
		PDZ_signaling	605..680	CDD:238492	23/74 (31%)
		PDZ	773..858	CDD:214570	19/86 (22%)
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175
		NPXY motif	207..210
		PDZ	229..315	CDD:214570	22/90 (24%)
		PDZ_signaling	336..418	CDD:238492	21/115 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		7/38 (18%)
		PDZ_signaling	463..539	CDD:238492	23/99 (23%)
		PDZ_signaling	596..680	CDD:238492	17/87 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000