DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and Patj

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	252/892 - (28%)
Similarity:	348/892 - (39%)	Gaps:	347/892 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STEWSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGF 68
            :..|...|.::|||||:||||.:|||:|:|||::.:.|||:|:||||||.|||:|:||..|::|.
  Rat   240 TVRWGHTEDVELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGM 304

  Fly    69 SSEQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATA 133
            :|||||.|||..|..||::|||                         ||
  Rat   305 TSEQVAQVLRNCGNSVRMLVAR-------------------------DP---------------- 328

  Fly   134 AVAAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSEL 198

  Rat   329 ----------------------------------------------------------------- 328

  Fly   199 AGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQ 263
            .|::|               ||                        ||.||  .||:..
  Rat   329 VGEIA---------------VT------------------------PPTPA--SLPVAL------ 346

  Fly   264 DQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVEL-HKNVYGLGITVAGY 327
                           .::|....||             ||...|||.||| .|:...|||.:.||
  Rat   347 ---------------PVVATRTLGS-------------DSSPFETYNVELVKKDGQSLGIRIVGY 383

  Fly   328 V--CEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLT 390
            |  ....:.|||:|||||.||||..:||||:||:||||||.::.|..|...||:|||...|||||
  Rat   384 VGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLT 448

  Fly   391 LERFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDAD 455
            |.|    ||                 :.|..|..:.......::.|  |.:..|:         .
  Rat   449 LVR----RK-----------------TSLSASPFEQPSSREAVAEP--PEVPELT---------G 481

  Fly   456 SIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLT 520
            |:..|.:..::||.:|      |.::...:|||::     |::.|    :..:.:|........:
  Rat   482 SLKPETNSRMEAEEIG------ERLDNLRKDTVQA-----LEKPD----VYPEDIPGCPENELKS 531

  Fly   521 NGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPT 585
            ...:|:     |.|.:...|..:|:.|.                        |.:|.......|.
  Rat   532 RWENLL-----GPDYEVMVATLDTQIAD------------------------DEELQKYSKLLPI 567

  Fly   586 NEAPVKAASPTAASLRVAWKSLGI---SLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPG 647
            :            :||     ||:   |.:|            ||||.||...|||....:|:|.
  Rat   568 H------------TLR-----LGMEVDSFDG------------HHYISSIAPGGPVDTLNLLQPE 603

  Fly   648 DELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQS 712
            ||||:||..:|.|....|.|..|||:|....|||.|...       .......|.|::.|.
  Rat   604 DELLEVNGVQLYGKSRREAVSFLKEVPPPFTLVCCRRLF-------DDEASVDEPRTVEPS---- 657

  Fly   713 LQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEK 777
                |.:|:.:.|:   ..:|..|.|.                       |||||.||..|::.|
  Rat   658 ----LLEAEVDRSV---DVSTEDDDGE-----------------------LALWSPEVKTVELVK 692

  Fly   778 TEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSI 842
            ..:|.||||||||||||...||||||.|:..|.||.:.|:.|||||:||.:..|....|.|||.:
  Rat   693 DCKGLGFSILDYQDPLDPMRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEV 757

  Fly   843 LKAMPPGLTRLGICRPLSASDS---------NSNSNIASPLGDSTST 880
            |||:|||:..||||:||...:.         :||:|     ||::.:
  Rat   758 LKAVPPGVVHLGICKPLVEEEKEEKEEHFIFHSNNN-----GDNSES 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	43/71 (61%)
		PDZ	307..393	CDD:214570	50/88 (57%)
		PDZ_signaling	605..680	CDD:238492	29/77 (38%)
		PDZ	773..858	CDD:214570	48/84 (57%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492	45/76 (59%)
		PDZ_signaling	366..450	CDD:238492	46/83 (55%)
		CtpA	<391..>511	CDD:223864	54/162 (33%)
		PDZ_signaling	572..636	CDD:238492	29/75 (39%)
		PDZ	684..773	CDD:214570	50/88 (57%)
		PDZ_signaling	1074..1165	CDD:238492
		PDZ	1244..1329	CDD:214570
		PDZ	1471..1578	CDD:214570
		PDZ_signaling	1590..1670	CDD:238492
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.860