DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and Patj

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	883	Identity:	251/883 - (28%)
Similarity:	336/883 - (38%)	Gaps:	344/883 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            |...|.::|||||:||||.:|||:|:|||::.:.|||:|:||||||.|||:|:||..|::|.:||
Mouse   243 WGHTEEVELINDGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSE 307

  Fly    72 QVATVLRQTGAQVRLIVAR-PVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAV 135
            |||.|||..|..||::||| ||...|:        .|..|..|   |..|       |:.||..
Mouse   308 QVAQVLRNCGNSVRMLVARDPVGEIAV--------TPPTPVSL---PVAL-------PAVATRT- 353

  Fly   136 AAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAG 200

Mouse   354 ----------------------------------------------------------------- 353

  Fly   201 DLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQ 265
                                           ||.|..||
Mouse   354 -------------------------------LDSDRSPF-------------------------- 361

  Fly   266 NRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVEL-HKNVYGLGITVAGYV- 328
                                                     |||.||| .|:...|||.:.|||
Mouse   362 -----------------------------------------ETYSVELVKKDGQSLGIRIVGYVG 385

  Fly   329 -CEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLE 392
             ....:.|||:|||||.||||..:||||:||:||||||.::.|..|...||:|||...||||||.
Mouse   386 TAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLV 450

  Fly   393 RFLRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLD-ADS 456
            |                .|.:.:.|..:.|..::...|                 |||..: |.|
Mouse   451 R----------------RKTSLSASPFEHSSSRETVAE-----------------PPKVPERAGS 482

  Fly   457 IATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTN 521
            ...|.:.:|:||.:|           ...|.:::|....|::.|    :..::||. ||...|.:
Mouse   483 PKPEANLSVEAEEIG-----------ERLDNLKNNTVQALEKPD----VYPEKVPG-SPENELKS 531

  Fly   522 GRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTN 586
            ....:|..|         .|....|..|:.....|.::...|                 :|..|
Mouse   532 RWENLLGPD---------YEVMVATLDAQIADDEELQKYSKL-----------------LPIHT- 569

  Fly   587 EAPVKAASPTAASLRVAWKSLGI---SLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGD 648
                         ||     ||:   |.:|            ||||.|:...|||....:|:|.|
Mouse   570 -------------LR-----LGMEVDSFDG------------HHYISSVAPGGPVDTLNLLQPED 604

  Fly   649 ELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSL 713
            |||:||..:|.|....|.|..|||:|....|||.|...       .......|.|::.|
Mouse   605 ELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLF-------DDEASVDEPRTMEP------ 656

  Fly   714 QNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENVSGLALWSCEVTAVDIEKT 778
                  |..|:.:..|....:.|                     ::...|||||.||..|::.|.
Mouse   657 ------ALLEAEVDHSVDVNIED---------------------DDDGELALWSPEVKTVELVKD 694

  Fly   779 EQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQGLELDEAVSIL 843
            .:|.||||||||||||...||||||.|:..|.||.:.|:.|||||:||.:..|....|.|||.:|
Mouse   695 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDNATLAEAVEVL 759

  Fly   844 KAMPPGLTRLGICRPLSASD--------SNSNSNIASP 873
            ||:|||:..||||:||...:        ||:|.:.:.|
Mouse   760 KAVPPGVVHLGICKPLVEDEKEERFSLHSNNNGDSSEP 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	43/71 (61%)
		PDZ	307..393	CDD:214570	50/88 (57%)
		PDZ_signaling	605..680	CDD:238492	28/77 (36%)
		PDZ	773..858	CDD:214570	48/84 (57%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492	45/76 (59%)
		PDZ_signaling	363..450	CDD:238492	48/86 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		9/48 (19%)
		PDZ_signaling	572..636	CDD:238492	28/75 (37%)
		PDZ	685..774	CDD:214570	50/88 (57%)
		PDZ_signaling	1072..1163	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219
		PDZ	1242..1327	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.860