DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and PARD3B

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	860	Identity:	175/860 - (20%)
Similarity:	295/860 - (34%)	Gaps:	267/860 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IDLINDGNGLG------FILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            :::..:|..||      |..:.||..|:.|:.:.....::|:|.....:.:::|..|:|...:..
Human   212 VEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 276

  Fly    72 QVATVLRQT--GAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAA 134
            |...|.||.  ...|.|.|..|......:...:.                 |.::|.|
Human   277 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG-----------------SLNIFGN------- 317

  Fly   135 VAAAAAAAAAAGSGSDG--------DVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQ 191
                          :||        .|.|...|..|:|.|           ..:.|...||::.|
Human   318 --------------NDGVLKTKVPPPVHGKSGLKTANLTG-----------TDSPETDASASLQQ 357

  Fly   192 LQ--QLSELAGDLADFPLPPI-------------------PGGGGHSMVTDSNAGQRPCPRLDLD 235
            .:  ::..|.|..:...|.|:                   |.|.|.::||..::...|.|....:
Human   358 NKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 422

  Fly   236 IVPFSILSPPPRPALQMLPLETQWRCVQDQNRHI-----ETVIA--------DSKRKLLANEDGG 287
            |:       |...|::...|::..|.::...|.:     |.::|        ::...::|.::|.
Human   423 IL-------PKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGH 480

  Fly   288 SASASGSGSPDSYMDSPETE---TYVVELH-KNVYGLGITVAGYVCEE--EDLSGIFVKSIIEGS 346
            .......|.||....|.||.   |:.:.|: ....|||:::.|....|  .|| |||:||||.|.
Human   481 FLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL-GIFIKSIIHGG 544

  Fly   347 AAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRG-------RK----- 399
            ||...|::::||:::||:|.||.|.:||:|:|.||.:     :::|..:||       |:
Human   545 AAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS-----MSMEGNIRGMIQLVILRRPERPM 604

  Fly   400 -------------YEHLQVALTEIK----------GTSAPSGLDRSQDKDQDQESQLSMPGSPSI 441
                         :|:.|.|:|..:          ||.:|          ||::..|.:|..
Human   605 EDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSP----------QDKQKGLLLPND--- 656

  Fly   442 ATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLT 506
               .|       |:|                        |:|...|..|.:...|:...||.|:.
Human   657 ---GW-------AES------------------------EVPPSPTPHSALGLGLEDYSHSSGVD 687

  Fly   507 K-----DQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDT 566
            .     ||......:.|.....|:.|......|     ..|:.....:..|.|.|:.. ||.|.|
Human   688 SAVYFPDQHINFRSVTPARQPESINLKASKSMD-----LVPDESKVHSLAGQKSESPS-KDFGPT 746

  Fly   567 ---KTDTDPDPDLDPGQMPTPTNEAPVKAASPTAA-------SLRVAWKSLGISLEGTVDVEC-G 620
               |..:..: .|.........|:.|.....|...       |.|.|   :..|.:|..::|. |
Human   747 LGLKKSSSLE-SLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAA---IDKSYDGPEEIEADG 807

  Fly   621 IEKRPHHYIRSILADGPVGRQGILR-----PGDELLQVNEHKLQGLRHIEVVKILKELPARVKLV 680
            :..:..|           ..||.|.     .|:..|:..|:|   .|.::..|..::...:.||.
Human   808 LSDKSSH-----------SGQGALNCESAPQGNSELEDMENK---ARKVKKTKEKEKKKEKGKLK 858

  Fly   681 CARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSG 745
            .......    ..:::||    |.:...|..::.....|.:              |.|..|...|
Human   859 VKEKKRK----EENEDPE----RKIKKKGFGAMLRFGKKKE--------------DKGGKAEQKG 901

  Fly   746 GTAGGGARSKSLENV 760
            ....||.|.:.||.:
Human   902 TLKHGGLREEELEKM 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	19/79 (24%)
		PDZ	307..393	CDD:214570	34/91 (37%)
		PDZ_signaling	605..680	CDD:238492	15/80 (19%)
		PDZ	773..858	CDD:214570
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492	19/83 (23%)
		PDZ_signaling	395..475	CDD:238492	15/86 (17%)
		PDZ_signaling	509..597	CDD:238492	36/93 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810