DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and grip2

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_031757025.1	Gene:	grip2 / 100495373	XenbaseID:	XB-GENE-854056	Length:	1115	Species:	Xenopus tropicalis

Alignment Length:	1022	Identity:	198/1022 - (19%)
Similarity:	323/1022 - (31%)	Gaps:	396/1022 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IDLINDGNGLGFILVGG------RSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71
            |.|..:||..||::.||      :|..:|:..:.|||.|:|:|.|::.|.||.:..::|...:..
Frog   190 ITLCKEGNSFGFVMRGGAHEDWHKSRPLVVTYVRPGGPADREGTLKVSDRLLCVDGISLHNITHT 254

  Fly    72 QVATVLRQ---------------------------------------------TGAQVRLIVARP 91
            ...::|||                                             |....::||...
Frog   255 DALSILRQCSQEAVFQIEYDVALMDTVTNASGPLLVEIAKTPGSTLGISLSTGTHRNKQVIVIDK 319

  Fly    92 VEPTAI----------DY------------------QTLA-----CQAPIIP---TKL-LSDPEE 119
            |:|.::          |:                  |.||     .:..|:|   ::| |..||.
Frog   320 VKPASVVDRCGALHPGDHILSIDGTSTEHCTLMEATQLLASIIENVKLEILPAHHSRLSLRPPET 384

  Fly   120 LS------RHLF-----------------------QNPSFATAAVAAAAAAAAAAG--------- 146
            :.      .|.:                       .|..:..:.|||..::::.||
Frog   385 VKVQKSDHHHCWDPCVNYCHTPHPGHCKTPTWNSTSNQEYCKSLVAANFSSSSVAGTPGFSSQNS 449

  Fly   147 ------------------------------SGSDGDVG-GGGVLDVASLVGLVRGGPAEG----- 175
                                          |.:...|| ||.::...|...::||.|..|
Frog   450 NTLPRTAHPMSPRTTMSRRRQKRKDHKSSLSLASSTVGPGGQIIHTESTEIILRGDPLNGFGIQL 514

  Fly   176 ------TE-LSA------VEPQPSA---AVLQ-----------------LQQLSELAGDLA---- 203
                  || ||:      :||...|   .:||                 |::.::|..|.|
Frog   515 QGGIFATETLSSPPLIRFIEPDSPAERCGLLQVGDRLLSINGILTEDGTLEEANQLLRDAALSNK 579

  Fly   204 -------DFPLPPIPGGGGHSM-----------VTDSNAGQRPC-PRLDLDIVPFSI------LS 243
                   |.....:|..|...:           :|.|:|.::|. |.:..||...|:      |.
Frog   580 VALEIEFDVAESVVPSSGTFHVKLPKRKGVELGITISSASRKPGEPLIISDIKKGSVAHRTGTLE 644

  Fly   244 PPPR-PALQMLPLETQWRCVQDQN----RHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDS 303
            |..: .|:..:.|:   .|..:..    |..|.::   |.|:..:||                :|
Frog   645 PGDKLLAIDNIRLD---NCSMEDAVQILRQCEDLV---KLKIRKDED----------------NS 687

  Fly   304 PETET-----YVVELHKNVYG--LGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIV 361
            .|.||     |.|||.:  ||  ||||::|   .||....|.:..:.:...||.:|.|.|.|||:
Frog   688 DEQETSGAIIYTVELKR--YGGPLGITISG---TEEPFDPIVISGLTKRGLAERTGAIHIGDRIL 747

  Fly   362 AVDGRSLSGVTNHQAVELLRNTDIVVHLTL----ERFLRGRKYEHLQVA---------------L 407
            |::..||.|....:|:.||:.....|.|.:    ||....|..:.:...               |
Frog   748 AINNVSLKGKPLSEAIHLLQMAGETVTLKIKKQAERIFPQRLSDSMNEGSDPEDDLTDSQKTSKL 812

  Fly   408 TEIKGTSAP-----------SGLD--------------------------RSQDKDQDQESQLSM 435
            ::|..|:.|           ||:|                          |.:......|.:.|.
Frog   813 SDIYSTAVPSVDSALESWDGSGIDAGYGSQGTYVPQAVGISLHPHEWRTSRQKSSTPPVEHRKSY 877

  Fly   436 PG-SPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRS 499
            |. ..|.....|..|....:.....|.|.  |..:..:.|...|.:|...    :|.:...::.|
Frog   878 PFLDGSFNEQDWEKPTRYPSQPNGLEADH--DDSFWRVFGEALEDLETCG----QSELLREIEAS 936

  Fly   500 DHSG-----GLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETER 559
            ..:|     ||...|:     ::..:|....:|.....:.......:.|.:.:|..:..|.|...
Frog   937 IMTGSVQGLGLDSSQI-----LLENSNQGGHVLFRKGSHPISSNSPKKENKLSQEARTKKEEVHD 996

  Fly   560 VKDLGD--TKTDTDPDPDLDPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIE 622
            .:.|..  .|.....|.|.|                            ..|.|:...: :|.|:
Frog   997 AQSLSTELLKVTVQKDMDTD----------------------------DFGFSVSDGL-LEKGV- 1031

  Fly   623 KRPHHYIRSILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHV 687
                 |:..|...||..|.| |:..|.:||||..:.:.......|.:|.:...|:.||.:||..|
Frog  1032 -----YVNMIRPGGPADRSG-LKTYDRILQVNHVRTRDFDCCLTVPLLSDAGGRLDLVISRGLSV 1090

  Fly   688 PSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATL 734
            .|                   |...::.:....:.||.   :||.||
Frog  1091 NS-------------------GEMGVEQIKGPIKMESQ---TSTKTL 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	24/122 (20%)
		PDZ	307..393	CDD:214570	33/96 (34%)
		PDZ_signaling	605..680	CDD:238492	19/74 (26%)
		PDZ	773..858	CDD:214570
grip2	XP_031757025.1	PDZ_signaling	87..169	CDD:238492
		PDZ_signaling	187..272	CDD:238492	24/81 (30%)
		PDZ_signaling	287..370	CDD:238492	9/82 (11%)
		PDZ_signaling	499..585	CDD:238492	17/85 (20%)
		PDZ_signaling	598..681	CDD:238492	17/88 (19%)
		PDZ_signaling	697..778	CDD:238492	31/85 (36%)
		PDZ_signaling	1007..1084	CDD:238492	23/112 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910