DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15803 and whrna

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	800	Identity:	156/800 - (19%)
Similarity:	239/800 - (29%)	Gaps:	315/800 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLSTEWSQVEVIDLINDGNGLGFILVGGR--STGVVIKALTPGGVAERDGRLQLGDHLLQIGEV 63
            |.|..:..:.:|..:::||..||.::.||.  |.|:.|..:..|..||..| :::||.:|   ||
Zfish   306 MQLLQDGDEKKVNLVLDDGRSLGLMIRGGAEYSLGIYITGVDRGSAAECGG-IKVGDQIL---EV 366

  Fly    64 NLRGFSS---EQVATVLRQTGAQVRLI--VARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRH 123
            |.|.|.|   ::...||:.:...:..:  |.|....     :|:..:...|.:..:||
Zfish   367 NGRSFLSIPHDEAVRVLKSSHHLMMTVKDVGRLPHT-----RTVVGETKWIASSQISD------- 419

  Fly   124 LFQNPSFATAAVAAAAAAAAAAGSGSDGDVGG--GGVLDVASLVGLVRGGPAEGTELSAVEPQPS 186
                 |.|:::|...:....|:.|...|...|  |..:.::|||...|....|.......||:..
Zfish   420 -----SSASSSVTGISLDQGASTSAKGGFYKGVAGSQVTLSSLVNQSRAMLEEQARHLLTEPERQ 479

  Fly   187 AAVLQLQQ---------------------------LSELAG-----DLADF----------PLPP 209
            .....:|:                           |||:.|     |:..|          .|..
Zfish   480 TMGYYIQEYRDGHVGVEQLVMALFELFNTHAKFSLLSEVRGIVTPQDVEKFDGLVLRREIDALKA 544

  Fly   210 IPGGG-----GHSMVT---------------------------DSNAGQ------RPCPRLDLDI 236
            ..|||     ..|||:                           ::|..|      ...|.:.||.
Zfish   545 RQGGGAGFQDSFSMVSYPDTLASSSASFMTNTTLSSARNDGVAENNGEQGSLEHSNALPDISLDE 609

  Fly   237 V------PFSILSPPPRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASG-- 293
            |      |.| ..|||.|.||..|                     |::..|:.....|:|.||
Zfish   610 VHSTSDSPPS-FKPPPPPGLQRRP---------------------SRKATLSKRPSSSSSQSGLY 652

  Fly   294 --------------SGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEEEDLSGIFVKSIIE 344
                          ..:|.::|..|
Zfish   653 FTAPSRSHTRESKHPKAPKAFMSPP---------------------------------------- 677

  Fly   345 GSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYEHLQVALTE 409
                   |.::|:     |....||.|:.|
Zfish   678 -------GTLKID-----VPASQLSVVSQH----------------------------------- 695

  Fly   410 IKGTSAPSG-LDRSQDKDQDQESQLSMPGSPSIATLSW-----------LPPKSLDADSIATEGD 462
                  |.| ..|.|..::.:.:|.|.|..|....:..           |||.|
Zfish   696 ------PIGPFPRVQSPNKAKPAQSSSPIPPPAPNVPAPPGPPPPPPPPLPPPS----------- 743

  Fly   463 EAVDAEYVGISGAEDEFIELPSRDTVESNMS--HVLDRSDHSGGLTKDQVPRISPIVPLTNGRSL 525
                               .|.:.|..|..|  |.:....|......| |..:.|: |...|.:|
Zfish   744 -------------------CPDKPTPSSPASNQHFVMVEVHRPNAEPD-VNEVRPL-PQVRGGTL 787

  Fly   526 ILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDLDPGQMPTPTNEAPV 590
            ....|||....|.......|:.:..|.:.|...|      |:...|       |.....|:..|.
Zfish   788 SQLSDSGQTLSEDSGVDIPESGRLSKDTSPRPAR------TRAPRD-------GHGGGETSAKPP 839

  Fly   591 KAASPTAASLRVAWKS---LGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQ 652
            ....|.:..:||| ||   |||::||..:.     ::|...|.:|...|.....|.|:.|..:|:
Zfish   840 GLLEPMSTLVRVA-KSASTLGIAIEGGANT-----RQPLPRIVTIQRGGSAHNCGQLKVGQVILE 898

  Fly   653 VNEHKLQGLRHIEVVKILKE 672
            ||...|:|..|.|..:::.|
Zfish   899 VNGVSLRGKEHREAARLIAE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	24/78 (31%)
		PDZ	307..393	CDD:214570	7/85 (8%)
		PDZ_signaling	605..680	CDD:238492	21/70 (30%)
		PDZ	773..858	CDD:214570
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822
		PDZ_signaling	174..255	CDD:238492
		PDZ_signaling	314..394	CDD:238492	25/83 (30%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	11/78 (14%)
		PDZ_signaling	848..919	CDD:238492	24/76 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900