DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15803 and patj

DIOPT Version :9

Sequence 1:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_002931635.3	Gene:	patj / 100036704	XenbaseID:	XB-GENE-998168	Length:	1829	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	244/903 - (27%)
Similarity:	339/903 - (37%)	Gaps:	368/903 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EWSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSS 70
            :|..||.|:|||||:||||.:|||:::||:::.:..||:|:|||||:.|||:||||:.|::|.:|
Frog   245 QWGHVEDIELINDGSGLGFGIVGGKASGVIVRTIVSGGLADRDGRLKTGDHILQIGDTNVQGMAS 309

  Fly    71 EQVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAV 135
            :|||.|||..|..|:::|||                         ||.|
Frog   310 DQVAQVLRNCGNSVKMVVAR-------------------------DPIE---------------- 333

  Fly   136 AAAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAG 200
                                                            :||.
Frog   334 ------------------------------------------------RPSK------------- 337

  Fly   201 DLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQ 265
                   ||.|.                       .:|...|  ||:.             |:..
Frog   338 -------PPAPA-----------------------TLPVGAL--PPKD-------------VKGD 357

  Fly   266 NRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYV-C 329
            |.:.:.|. |.|   |..::|.|                               |||||.||. .
Frog   358 NENTDNVY-DIK---LTKKEGQS-------------------------------LGITVVGYTGA 387

  Fly   330 EEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERF 394
            .....|||:|||||.||||:.||.||:.|||:||||.::...:|...|..||||...|||||
Frog   388 FNGGSSGIYVKSIIPGSAADQSGCIQVQDRIIAVDGVNIQDYSNQDVVAALRNTGQTVHLTL--- 449

  Fly   395 LRGRKYEHLQVALTEIKGTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIAT 459
              .|..|.|::..||.....|..||                |..|        |...::..|...
Frog   450 --SRSKELLELVATERSLVRAVPGL----------------PSDP--------PVPEINKSSANE 488

  Fly   460 EGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRS 524
            |..|.||       ..::|.|                     :|.|:
Frog   489 ENQEQVD-------NYKNEMI---------------------TGSLS------------------ 507

  Fly   525 LILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTD-------PDPDLDPGQMP 582
                                          |:|..:|...:.:...|       .||.:|
Frog   508 ------------------------------PQTSILKSKWEQRLGPDYLVMVVNLDPKID----- 537

  Fly   583 TPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPG 647
               ::|.::..|..   |.:....||:.|: :.|        .||||.||..:|||.:.||.:|.
Frog   538 ---DDAELQKYSKL---LPIHTMRLGVELD-SFD--------GHHYISSIAPEGPVAKLGIFQPE 587

  Fly   648 DELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARG---------THVPSVINTSQNPEAFETR 703
            ||||:||..:|.|....|.|..|||:|....|||.|.         ..||:.::|..|      :
Frog   588 DELLEVNGVQLYGKSRREAVSFLKEVPPPFTLVCCRRMVDDENETFVDVPNTLDTKDN------K 646

  Fly   704 SLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENV------SG 762
            :.:|...:..|.:.|..:|.|..                           ::.|||:      ..
Frog   647 NEIPVTEEEDQTVQSSERSNSEY---------------------------AQPLENLVTEEDDGE 684

  Fly   763 LALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVG 827
            ||:||.||..|::||...|.||||||||||||...:|:||:.|:..|.||.:.:|.|||||:.|.
Frog   685 LAMWSSEVKVVELEKDSGGLGFSILDYQDPLDPARTVLVIQSLVSNGVAETSGQILPGDRLVFVN 749

  Fly   828 DRLLQGLELDEAVSILKAMPPGLTRLGICRPLSAS-----DSNSNSNIASPLGDSTST 880
            |..:....|::||.||.::|||.||||||:||..|     |..:|........|||:|
Frog   750 DNYMDNASLEDAVQILTSVPPGRTRLGICKPLVGSIKEEKDIYTNLEELEDNTDSTAT 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	38/71 (54%)
		PDZ	307..393	CDD:214570	41/86 (48%)
		PDZ_signaling	605..680	CDD:238492	30/74 (41%)
		PDZ	773..858	CDD:214570	45/84 (54%)
patj	XP_002931635.3	L27_2	13..70	CDD:312549
		PDZ_signaling	142..225	CDD:238492
		PDZ_signaling	256..328	CDD:238492	38/71 (54%)
		PDZ_signaling	364..449	CDD:238492	45/119 (38%)
		PDZ_signaling	556..620	CDD:238492	30/72 (42%)
		PDZ_signaling	692..770	CDD:238492	37/77 (48%)
		PDZ_signaling	1014..1105	CDD:238492
		PDZ	1186..1271	CDD:214570
		PDZ	1383..1468	CDD:214570
		PDZ_signaling	1480..1560	CDD:238492
		PDZ_signaling	1624..1709	CDD:238492
		PDZ_signaling	1744..1828	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000