Protein Alignment naz and HSD17B6

DIOPT Version :10

• Sequence 1: NP_732328.1
• Gene: naz / 42204
• FlyBaseID: FBgn0286852
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_003716.2
• Gene: HSD17B6 / 8630
• HGNCID: 23316
• Length: 317
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 65/284 - (22%)
• Similarity: 112/284 - (39%)
• Gaps: 70/284 - (24%)

  Fly    45 NQIKEQIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKRELGCRTPLNSLDED 109
            :.::::.|.:||.:||.|..:|:.|..||.|::.||...:..::...
Human    25 SHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRG------------------ 71

  Fly   110 DNPEDRYFVEARYLDLCSLRSVHHFAGQLMAEF---ERIDVLVNNAGVVFANT---QMPTEDGFE 168
             ...||  :|...||:..:.|: ..|.|.:.|.   ..:..||||||::...|   .:.|||...
Human    72 -QTSDR--LETVTLDVTKMESI-AAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMN 132

  Fly   169 RHSQVNYLAPFLLTHLLLPHLQRSEQGRILFVSAHAHQGAKIDFDDPLNVGTWSVKFHAREAFAH 233
            . .:||.:....:|..:|| |.|..:|||:.||:...:.|       ..||.:.|..:..|||:.
Human   133 M-LKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVA-------FFVGGYCVSKYGVEAFSD 188

  Fly   234 SKLCVLLATRWMARELKGTSVTVNCCTPGLVRGTRHFRNSPLMSSLCVKAVTYPWMWLFMKNAYE 298
            .          :.||::...|.::...||      :||......:..::.:...|     |.|
Human   189 I----------LRREIQHFGVKISIVEPG------YFRTGMTNMTQSLERMKQSW-----KEA-- 230

  Fly   299 GAQCAIRLATDPQLKEVTGEYFND 322
                      ...:||..|:.:.|
Human   231 ----------PKHIKETYGQQYFD 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
naz	NP_732328.1	retinol-DH_like_SDR_c_like	50..342	CDD:212492	65/279 (23%)
HSD17B6	NP_003716.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	65/279 (23%)