DRSC/TRiP Functional Genomics Resources

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Protein Alignment naz and Wwox

DIOPT Version :9

Sequence 1:NP_001287387.1 Gene:naz / 42204 FlyBaseID:FBgn0286852 Length:406 Species:Drosophila melanogaster
Sequence 2:NP_062519.2 Gene:Wwox / 80707 MGIID:1931237 Length:414 Species:Mus musculus


Alignment Length:327 Identity:108/327 - (33%)
Similarity:145/327 - (44%) Gaps:60/327 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 QIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKRELGCRTPLNSLDEDDNPED 114
            ::|:|||.|||||||.|::.|..|..:|||||||.....|.:.|..|.                .
Mouse   125 KVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEW----------------H 173

  Fly   115 RYFVEARYLDLCSLRSVHHFAGQLMAEFERIDVLVNNAGVVFANTQMPTEDGFERHSQVNYLAPF 179
            :..|||..|||..||||.|||....|:...:.|||.||| .||.....|:||.|...|||:|..|
Mouse   174 KAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAG-TFALPWGLTKDGLETTFQVNHLGHF 237

  Fly   180 LLTHLLLPHLQRSEQGRILFVSAHAHQ-------GAKIDFD--DPLNVGTWSVKFHAREAFAHSK 235
            .|..||...|.||...|::.||:.:|:       ..|:|..  .|.....|     |..|:..||
Mouse   238 YLVQLLQDVLCRSSPARVIVVSSESHRFTDINDSSGKLDLSRLSPPRSDYW-----AMLAYNRSK 297

  Fly   236 LCVLLATRWMARELKGTSVTVNCCTPGLVRGTRHFRNSPLMSSLCVKAVTYPWMWL--------F 292
            ||.:|.:..:.|.|....||.|...||.:..:...|||              |::.        |
Mouse   298 LCNILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHRNS--------------WVYKLLFTLARPF 348

  Fly   293 MKNAYEGAQCAIRLATDPQLKEVTGEYFNDCEIAASSVTGQDKELAKKLYMQTIKTLESVTKLTV 357
            .|:..:||...:..|..|:|:.:.|.|||:|.....|...|.:|.|:.|:       |...:|..
Mouse   349 TKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALW-------ELSERLIQ 406

  Fly   358 DR 359
            ||
Mouse   407 DR 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nazNP_001287387.1 FabG 47..318 CDD:223959 94/284 (33%)
retinol-DH_like_SDR_c_like 50..342 CDD:212492 103/308 (33%)
WwoxNP_062519.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
WW 19..47 CDD:238122
Nuclear localization signal 50..55
WW 60..90 CDD:238122
PRK06196 107..404 CDD:235736 105/321 (33%)
human_WWOX_like_SDR_c-like 124..407 CDD:187669 106/324 (33%)
Interaction with MAPT. /evidence=ECO:0000269|PubMed:15126504 125..414 108/327 (33%)
Mediates targeting to the mitochondria 209..273 24/64 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1208
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000061
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X72
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.810

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