Protein Alignment naz and RDH12

DIOPT Version :10

• Sequence 1: NP_732328.1
• Gene: naz / 42204
• FlyBaseID: FBgn0286852
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_689656.2
• Gene: RDH12 / 145226
• HGNCID: 19977
• Length: 316
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 113/318 - (35%)
• Similarity: 173/318 - (54%)
• Gaps: 40/318 - (12%)

  Fly    31 TVRTLMSGQRCPNDNQIKEQIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKR 95
            ::|...:|..|..:.|:..::||:||.|:|||.|.|:.||.||.|:.:|||::..|:.||:.|:
Human    21 SIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIR- 84

  Fly    96 ELGCRTPLNSLDEDDNPEDRYFVEARYLDLCSLRSVHHFAGQLMAEFERIDVLVNNAGVVFANTQ 160
                      :|..::.     |..|.|||...:|:..||...:||.:::.:|:|||||:.. ..
Human    85 ----------VDTKNSQ-----VLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMC-PY 133

  Fly   161 MPTEDGFERHSQVNYLAPFLLTHLLLPHLQRSEQGRILFVSAHAHQGAKIDFDDPLNVGTWSVKF 225
            ..|.||||.|..||:|..||||:|||..|:.|...|::.||:.||...||.|.|..:...:|..|
Human   134 SKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGF 198

  Fly   226 HAREAFAHSKLCVLLATRWMARELKGTSVTVNCCTPGLVRG--TRHFRNSPLMSSLCVKAVTYPW 288
                |:.||||..:|.||.:|:.|:||.||.....||:||.  .||      .|.||:
Human   199 ----AYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRH------SSLLCL------- 246

  Fly   289 MWL----FMKNAYEGAQCAIRLATDPQLKEVTGEYFNDCEIAASSVTGQDKELAKKLY 342
            :|.    |:|.|.||||.::..|....|:.::|:||:||:....|...::.:.|::|:
Human   247 LWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLW 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
naz	NP_732328.1	retinol-DH_like_SDR_c_like	50..342	CDD:212492	108/297 (36%)
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	109/300 (36%)