DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and CRK

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001190048.1	Gene:	CRK / 824217	AraportID:	AT3G50530	Length:	632	Species:	Arabidopsis thaliana

Alignment Length:	534	Identity:	131/534 - (24%)
Similarity:	210/534 - (39%)	Gaps:	143/534 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 VNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDGQSEQSQSSTSSSPSANI 384
            :.|...:|..:....|.|.|||...........|||:|.:...::::.:.::|......|||.
plant     1 MGLCTSKPNSSNSDQTPARNSPLPASESVKPSSSSVNGEDQCVTTTNNEGKKSPFFPFYSPSP-- 63

  Fly   385 PLMRIVQSVKHTKKRGGQALKEGWLVHY-------------TSLDKAVKRYYWRLDSKTITLFVS 436
                                     .||             .|.:...||::.|       .|..
plant    64 -------------------------AHYFFSKKTPARSPATNSTNSTPKRFFKR-------PFPP 96

  Fly   437 EQGSKYHKELPLAELLSIESHLGDPRPECNYCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDS 501
            ...:|:.:.:       :....|..:|..:     .:|.     |.:.:.|
plant    97 PSPAKHIRAV-------LARRHGSVKPNSS-----AIPE-----GSEAEGG-------------- 130

  Fly   502 GIGSDIAKSWETSIRQAFMHVTNTQCCESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQ 566
            |:|.|.:..:..|....:                ::|       ||| |.|.||.......||..
plant   131 GVGLDKSFGFSKSFASKY----------------ELG-------DEV-GRGHFGYTCAAKFKKGD 171

  Fly   567 ---REVAIKVIDKLRFPTKQEAQ-LKNEVAILQNIS-HCGVVNLERMFETPERIFVVMEKLK-GD 625
               ::||:|||.|.:..|....: ::.||.||:.:| |..:.:....:|..:.:::|||..: |:
plant   172 NKGQQVAVKVIPKAKMTTAIAIEDVRREVKILRALSGHNNLPHFYDAYEDHDNVYIVMELCEGGE 236

  Fly   626 MLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFG- 689
            :|:.|||.. |:.:|...|.::.|||..:.:.|.|.:||.||||||.|.:|..:..|:|..|||
plant   237 LLDRILSRG-GKYTEEDAKTVMIQILNVVAFCHLQGVVHRDLKPENFLFTSKEDTSQLKAIDFGL 300

  Fly   690 -----------------------------YARIIGEKSFR-RSVVGTPAYLAPEVLRNKGYNRSL 724
                                         ||..|.....| ..:||:..|:||||| ::.|:...
plant   301 SDYVRPGKALRLYAICKLRFQNLETSICLYALTIAFADERLNDIVGSAYYVAPEVL-HRSYSTEA 364

  Fly   725 DMWSVGVIIYVSLSGTFPF--NEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKR 787
            |:||||||:|:.|.|:.||  ..|..|...:..|...:...||..:||.|.|.:..||....|||
plant   365 DIWSVGVIVYILLCGSRPFWARTESGIFRAVLKADPSFDDPPWPLLSSEARDFVKRLLNKDPRKR 429

  Fly   788 YTVDKSLLHYWLQD 801
            .|..::|.|.|::|
plant   430 LTAAQALSHPWIKD 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556
		C1	223..272	CDD:197519
		PH_PKD	396..522	CDD:269945	17/138 (12%)
		STKc_PKD	539..798	CDD:270984	96/297 (32%)
		S_TKc	547..799	CDD:214567	95/290 (33%)
CRK	NP_001190048.1	STKc_CAMK	147..440	CDD:270687	97/318 (31%)
		S_TKc	148..441	CDD:214567	97/318 (31%)
		Glo_EDI_BRP_like	526..>597	CDD:301325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000