DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and prkd4

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001170925.1	Gene:	prkd4 / 565810	ZFINID:	ZDB-GENE-080204-93	Length:	660	Species:	Danio rerio

Alignment Length:	757	Identity:	357/757 - (47%)
Similarity:	454/757 - (59%)	Gaps:	131/757 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 MLFGLVRQGLKCDGCGQNYHKRCVVKIPNNCNRSNDATSRR---SFTL---QAPRSPS-----GS 177
            ||:|||||||||||||.::||||.:::||:|:|    ..||   |.:|   ..||:||     |.
Zfish     1 MLWGLVRQGLKCDGCGLDFHKRCALRLPNDCSR----VYRRCGPSLSLLPPGRPRAPSLSIHTGG 61

  Fly   178 SQQSLVSTEDSTGRNDSSSSLNI-----PGRHQRTHSSGSRNGLMVLRIPHTFMVHTYGIPTVCQ 237
            |.:.:..::....|..|.:.:::     .|:..|.            |:||||.:|||..|||||
Zfish    62 SLEEISLSKPMRSRPPSLADVSVSVGMSEGKEGRP------------RVPHTFHIHTYTKPTVCQ 114

  Fly   238 LCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSD 302
            .|.:||||||:|||||.||::|.|::|...||.:|.||                   |...:|||
Zfish   115 HCFRLLKGLFRQGLQCSDCKFNCHRRCQALVPPECRGE-------------------RANGEDSD 160

  Fly   303 GDDGSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDG 367
            ....||    ::.....||.:....|         :..||
Zfish   161 AGQESE----ENVAVESVNALYEELR---------YKDPP------------------------- 187

  Fly   368 QSEQ---SQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSK 429
             .||   .|...:...|:||||||:||||||:|:||...||:|||:|.||.|...||:||.||.|
Zfish   188 -LEQLMPPQMPVTPCFSSNIPLMRVVQSVKHSKRRGSGVLKKGWLIHNTSTDTLKKRHYWVLDGK 251

  Fly   430 TITLFVSEQGSKYHKELPLAELLSIESHLGDPRPECNYCFELRLPNLSY--FVGQDPQVGAKEEQ 492
            :|||:.:|..|||:||:.|:|:|.:.   |..:...::..||:..:|.|  |..||
Zfish   252 SITLYPNENTSKYYKEISLSEVLQVR---GADQISGDHSLELQTGSLVYCVFAEQD--------- 304

  Fly   493 AVRLPPPDSGIGSDIAKSWETSIRQAFMHVTNTQCCESEE--------QVQDMGQLYQIFPDEVL 549
                           ..:||::::.|...|..:...:|||        ..||:.:|||||.||||
Zfish   305 ---------------GPAWESALKLALRPVQGSTAEDSEENGDEKNGDNSQDISELYQIFSDEVL 354

  Fly   550 GSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPER 614
            |||||||||||.|::|.|.||||||||.|||:|||.|.||||||||.:||..|::||.||||.|.
Zfish   355 GSGQFGVVYGGTHRQTGRPVAIKVIDKTRFPSKQEQQTKNEVAILQRLSHPAVIHLEGMFETKEY 419

  Fly   615 IFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAE 679
            .|||||||..|||||||||..|||.||.|:||:||:|.||:|||.:||.|||||||||||:|...
Zfish   420 TFVVMEKLHSDMLEMILSHENGRLPERNTRFLVTQVLEALRYLHMRNIAHCDLKPENVLLASPEP 484

  Fly   680 FPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFN 744
            ||||||||||:||||||||||||:|||||||||||:.|.|||||||.|:||||:|||||||||||
Zfish   485 FPQVKLCDFGFARIIGEKSFRRSIVGTPAYLAPEVINNHGYNRSLDTWAVGVILYVSLSGTFPFN 549

  Fly   745 EEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLR 809
            |:||||.||.||:||||..||..||..|::||||||||..|:|::|.|::.|.|.|:.|.:.|||
Zfish   550 EDEDINQQITNASFMYPRQPWSLISLEAVNLINNLLQVVVRRRFSVGKAMGHPWFQNFQLWCDLR 614

  Fly   810 NLEAQVGAGRYLTHEADDLRWDCAGDMXPGCEPEAILESTTE 851
            ..|.::|. ||||||:||..|...........||.:.|:..:
Zfish   615 EFELRMGY-RYLTHESDDSHWRAYAQEKRLSFPEHLAEAAEQ 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	21/29 (72%)
		C1	223..272	CDD:197519	30/48 (63%)
		PH_PKD	396..522	CDD:269945	42/127 (33%)
		STKc_PKD	539..798	CDD:270984	190/258 (74%)
		S_TKc	547..799	CDD:214567	184/251 (73%)
prkd4	NP_001170925.1	C1	<1..31	CDD:294036	21/29 (72%)
		C1	100..149	CDD:237996	30/48 (63%)
		PH_PKD	219..319	CDD:269945	42/126 (33%)
		STKc_PKD	344..603	CDD:270984	190/258 (74%)
		S_TKc	352..604	CDD:214567	184/251 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6428
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920