DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and PRKD1

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001316998.1	Gene:	PRKD1 / 5587	HGNCID:	9407	Length:	920	Species:	Homo sapiens

Alignment Length:	913	Identity:	468/913 - (51%)
Similarity:	600/913 - (65%)	Gaps:	123/913 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTFLFQFGSVRDAVCVPANS---LTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNV 67
            ::|..|.|..|:.|.:..:|   .:|..::::||..::.|.|:.|...:.::||||.||.::.|:
Human    49 ISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENI 113

  Fly    68 LHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQG 132
            |.::.:|:::.:..|:|:||:||    .|.|...::||:|.||||:.|.|||.|||||:||||||
Human   114 LQLVKAASDIQEGDLIEVVLSAS----ATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG 174

  Fly   133 LKCDGCGQNYHKRCVVKIPNNCNR--------------SNDATSRRSFTLQAPRSPSGSSQQSLV 183
            |||:|||.||||||..||||||:.              |...||....:..||..|       |:
Human   175 LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEP-------LL 232

  Fly   184 STEDSTGRNDSSSSLNIPGRHQRTHSSG--------SRNGLMVLRIPHTFMVHTYGIPTVCQLCK 240
            |.. |.|....|.|.:..||.:|::|..        .:..:..:::||||::|:|..|||||.||
Human   233 SPV-SPGFEQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCK 296

  Fly   241 KLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDD 305
            |||||||:|||||:||::|.||:|..|||::|.||..::...:..|| |.|....|..||:|
Human   297 KLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGA-ESDVVMEEGSDDND--- 357

  Fly   306 GSEYGKYKSAMSSGV--NLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDGQ 368
                    |..:||:  ::.....::|..|:....|...|:                  ...|..
Human   358 --------SERNSGLMDDMEEAMVQDAEMAMAECQNDSGEM------------------QDPDPD 396

  Fly   369 SEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITL 433
            .|.:..:.|.|.|.||||||:||||||||::....:||||:|||||.|...||:|||||||.|||
Human   397 HEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITL 461

  Fly   434 FVSEQGSKYHKELPLAELLSIE----SHLGDPRPECNYCFELRLPNLSYFVGQ---DPQVGAKEE 491
            |.::.||:|:||:||:|:||:|    |.| .|.....:|||:...|:.|:||:   :|.
Human   462 FQNDTGSRYYKEIPLSEILSLEPVKTSAL-IPNGANPHCFEITTANVVYYVGENVVNPS------ 519

  Fly   492 QAVRLPPPD-----SGIGSDIAKSWETSIRQAFMHV--------TNTQC------------CESE 531
                .|.|:     ||:|:|:|:.||.:|:.|.|.|        |.|..            |:.:
Human   520 ----SPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQ 580

  Fly   532 EQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQN 596
            |.| |:..:|||||||||||||||:||||.|:||.|:||||:|||||||||||:||:||||||||
Human   581 ENV-DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQN 644

  Fly   597 ISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQN 661
            :.|.||||||.|||||||:|||||||.|||||||||..:|||.|.:|||||||||:||::||.:|
Human   645 LHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKN 709

  Fly   662 IVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDM 726
            |||||||||||||:|...||||||||||:||||||||||||||||||||||||||||||||||||
Human   710 IVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDM 774

  Fly   727 WSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVD 791
            |||||||||||||||||||:|||:|||||||||||||||||||..||||||||||||.||||:||
Human   775 WSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVD 839

  Fly   792 KSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD-CAGDMXPGCEPEAILESTTELISC 855
            |:|.|.||||.||:.|||.||.::|. ||:|||:|||||: .||:..        |:..|.||:.
Human   840 KTLSHPWLQDYQTWLDLRELECKIGE-RYITHESDDLRWEKYAGEQG--------LQYPTHLINP 895

  Fly   856 SAN 858
            ||:
Human   896 SAS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	35/44 (80%)
		C1	223..272	CDD:197519	33/48 (69%)
		PH_PKD	396..522	CDD:269945	59/137 (43%)
		STKc_PKD	539..798	CDD:270984	218/258 (84%)
		S_TKc	547..799	CDD:214567	212/251 (84%)
PRKD1	NP_001316998.1	C1_1	147..196	CDD:278556	37/48 (77%)
		C1	279..328	CDD:237996	33/48 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..410		6/42 (14%)
		PH_PKD	424..551	CDD:269945	59/137 (43%)
		STKc_PKD	587..846	CDD:270984	218/258 (84%)
		S_TKc	595..847	CDD:214567	212/251 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159972
Domainoid	1	1.000	436	1.000	Domainoid score	I569
eggNOG	1	0.900	-	-		E1_KOG4236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	842	1.000	Inparanoid score	I447
Isobase	1	0.950	-	0	Normalized mean entropy	S1932
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm41732
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750