Protein Alignment PKD and prkd3

DIOPT Version :10

• Sequence 1: NP_001262705.1
• Gene: PKD / 42203
• FlyBaseID: FBgn0038603
• Length: 906
• Species: Drosophila melanogaster
• Sequence 2: XP_685483.4
• Gene: prkd3 / 557337
• ZFINID: ZDB-GENE-130530-880
• Length: 891
• Species: Danio rerio
• Alignment Length: 880
• Identity: 452/880 - (51%)
• Similarity: 566/880 - (64%)
• Gaps: 127/880 - (14%)

  Fly     6 VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHI 70
            |:||.|.|..|:.|.:..:.|:|.::|||.|..::.|.|:.|...|.::||||.||.::.|:|..
Zfish    58 VSFLLQIGLTREMVTLDPHDLSLSSVKDLVCSIVDQKFPECGFFGLYDKILLFRHDLNSDNILQR 122

  Fly    71 INSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC 135
            :.||.|:.:..|:|:||:|.    .|.|...::||:|.|||||.|||||:|||||:|||||||||
Zfish   123 LTSAEEIHEGDLIEVVLSAQ----ATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC 183

  Fly   136 DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSSSLNI 200
            :|||.||||||..||||||   :....||...:..| .||       :|.........::|||
Zfish   184 EGCGLNYHKRCAFKIPNNC---SGVRKRRLSNVSLP-GPS-------LSVPRPAPAEHATSSL-- 235

  Fly   201 PGRHQRTHSS-GSR----NG------LMVL---RIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGL 251
              ..||.|.. |.|    :|      .|||   ::||||::|||..||:||.||:||||||:||:
Zfish   236 --EEQRPHQEPGKRIPSWSGRPIWMEKMVLGRVKVPHTFVIHTYTRPTICQYCKRLLKGLFRQGM 298

  Fly   252 QCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKYKSAM 316
            ||:||::|.||:|..|||.||.|                      .|:......|.:........
Zfish   299 QCKDCKFNCHKRCASKVPKDCLG----------------------VFNGEPASPGPDSDSTMEVD 341

  Fly   317 SSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDG------QSEQSQSS 375
            ||.||..:||                     ||.|....:..|......|.      :.|:...:
Zfish   342 SSDVNSDSGR---------------------GLDDSEEPTTPEDKIFFMDSPFMDREKDEEPVKT 385

  Fly   376 TSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGS 440
            .|.|.|.||||||:||||||||:|....:||||:|||||.|...||:|||||||.:|||.::.|:
Zfish   386 ISPSTSTNIPLMRVVQSVKHTKRRSSTVVKEGWMVHYTSKDNLRKRHYWRLDSKCLTLFQNDSGA 450

  Fly   441 KYHKELPLAELLSIE--------SHLGDPRPECNYCFELRLPNLSYFVGQDPQVGAKEEQAVRLP 497
            ||:||:||:|:|.:|        :..|:|     :|||:....:.|:||::  .|...   :.:.
Zfish   451 KYYKEIPLSEILQVEVARDFGSLALGGNP-----HCFEIITATMVYYVGEN--TGGPH---LHIH 505

  Fly   498 PP---DSGIGSDIAKSWETSIRQAFMHVTNT--------------------QCCESEEQVQ---D 536
            .|   ..|:|.::|:|||.:||||.|.|..|                    ....|..|:|   |
Zfish   506 SPALATGGVGLEVAQSWERAIRQALMPVPVTPQPSVGTAAGQSKDHKELSISISVSNSQIQENVD 570

  Fly   537 MGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCG 601
            :..:||||.||||||||||:||||.|:||.|:||||||||:|||||||:||:||||||||:.|.|
Zfish   571 ISSIYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPG 635

  Fly   602 VVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCD 666
            :||||.|||||||:|||||||.|||||||||..:.:|.||:||||:||||:||::||.:||||||
Zfish   636 IVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSKLPERITKFLVTQILVALRHLHFKNIVHCD 700

  Fly   667 LKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGV 731
            ||||||||:|...||||||||||:||||||||||||||||||||||||||:||||||||||||||
Zfish   701 LKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGV 765

  Fly   732 IIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLH 796
            ||||||||||||||:||||||||||||||||.|||:||:.|.||||||||||.||||:|||:|.|
Zfish   766 IIYVSLSGTFPFNEDEDINDQIQNAAFMYPPTPWKDISAEATDLINNLLQVKMRKRYSVDKTLSH 830

  Fly   797 YWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD 831
            .||||.||:.|||..|.:.|. ||:|||:||.||:
Zfish   831 PWLQDYQTWLDLREFETRRGE-RYITHESDDARWE 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_PKD_rpt1	102..157	CDD:410345	42/54 (78%)
		C1_PKD_rpt2	222..275	CDD:410346	34/52 (65%)
		PH_PKD	396..522	CDD:269945	56/136 (41%)
		STKc_PKD	539..798	CDD:270984	211/258 (82%)
prkd3	XP_685483.4	C1_PKD3_rpt1	143..217	CDD:410391	47/77 (61%)
		C1	265..331	CDD:412127	36/87 (41%)
		PH_PKD	406..533	CDD:269945	56/136 (41%)
		STKc_PKD	573..832	CDD:270984	211/258 (82%)