DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and prkd3

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	XP_685483.4	Gene:	prkd3 / 557337	ZFINID:	ZDB-GENE-130530-880	Length:	891	Species:	Danio rerio

Alignment Length:	880	Identity:	452/880 - (51%)
Similarity:	566/880 - (64%)	Gaps:	127/880 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHI 70
            |:||.|.|..|:.|.:..:.|:|.::|||.|..::.|.|:.|...|.::||||.||.::.|:|..
Zfish    58 VSFLLQIGLTREMVTLDPHDLSLSSVKDLVCSIVDQKFPECGFFGLYDKILLFRHDLNSDNILQR 122

  Fly    71 INSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC 135
            :.||.|:.:..|:|:||:|.    .|.|...::||:|.|||||.|||||:|||||:|||||||||
Zfish   123 LTSAEEIHEGDLIEVVLSAQ----ATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC 183

  Fly   136 DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSSSLNI 200
            :|||.||||||..||||||   :....||...:..| .||       :|.........::|||
Zfish   184 EGCGLNYHKRCAFKIPNNC---SGVRKRRLSNVSLP-GPS-------LSVPRPAPAEHATSSL-- 235

  Fly   201 PGRHQRTHSS-GSR----NG------LMVL---RIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGL 251
              ..||.|.. |.|    :|      .|||   ::||||::|||..||:||.||:||||||:||:
Zfish   236 --EEQRPHQEPGKRIPSWSGRPIWMEKMVLGRVKVPHTFVIHTYTRPTICQYCKRLLKGLFRQGM 298

  Fly   252 QCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKYKSAM 316
            ||:||::|.||:|..|||.||.|                      .|:......|.:........
Zfish   299 QCKDCKFNCHKRCASKVPKDCLG----------------------VFNGEPASPGPDSDSTMEVD 341

  Fly   317 SSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDG------QSEQSQSS 375
            ||.||..:||                     ||.|....:..|......|.      :.|:...:
Zfish   342 SSDVNSDSGR---------------------GLDDSEEPTTPEDKIFFMDSPFMDREKDEEPVKT 385

  Fly   376 TSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGS 440
            .|.|.|.||||||:||||||||:|....:||||:|||||.|...||:|||||||.:|||.::.|:
Zfish   386 ISPSTSTNIPLMRVVQSVKHTKRRSSTVVKEGWMVHYTSKDNLRKRHYWRLDSKCLTLFQNDSGA 450

  Fly   441 KYHKELPLAELLSIE--------SHLGDPRPECNYCFELRLPNLSYFVGQDPQVGAKEEQAVRLP 497
            ||:||:||:|:|.:|        :..|:|     :|||:....:.|:||::  .|...   :.:.
Zfish   451 KYYKEIPLSEILQVEVARDFGSLALGGNP-----HCFEIITATMVYYVGEN--TGGPH---LHIH 505

  Fly   498 PP---DSGIGSDIAKSWETSIRQAFMHVTNT--------------------QCCESEEQVQ---D 536
            .|   ..|:|.::|:|||.:||||.|.|..|                    ....|..|:|   |
Zfish   506 SPALATGGVGLEVAQSWERAIRQALMPVPVTPQPSVGTAAGQSKDHKELSISISVSNSQIQENVD 570

  Fly   537 MGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCG 601
            :..:||||.||||||||||:||||.|:||.|:||||||||:|||||||:||:||||||||:.|.|
Zfish   571 ISSIYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPG 635

  Fly   602 VVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCD 666
            :||||.|||||||:|||||||.|||||||||..:.:|.||:||||:||||:||::||.:||||||
Zfish   636 IVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSKLPERITKFLVTQILVALRHLHFKNIVHCD 700

  Fly   667 LKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGV 731
            ||||||||:|...||||||||||:||||||||||||||||||||||||||:||||||||||||||
Zfish   701 LKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGV 765

  Fly   732 IIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLH 796
            ||||||||||||||:||||||||||||||||.|||:||:.|.||||||||||.||||:|||:|.|
Zfish   766 IIYVSLSGTFPFNEDEDINDQIQNAAFMYPPTPWKDISAEATDLINNLLQVKMRKRYSVDKTLSH 830

  Fly   797 YWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD 831
            .||||.||:.|||..|.:.|. ||:|||:||.||:
Zfish   831 PWLQDYQTWLDLREFETRRGE-RYITHESDDARWE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	37/44 (84%)
		C1	223..272	CDD:197519	31/48 (65%)
		PH_PKD	396..522	CDD:269945	56/136 (41%)
		STKc_PKD	539..798	CDD:270984	211/258 (82%)
		S_TKc	547..799	CDD:214567	206/251 (82%)
prkd3	XP_685483.4	C1_1	153..202	CDD:278556	39/48 (81%)
		C1	270..319	CDD:237996	31/48 (65%)
		PH_PKD	406..533	CDD:269945	56/136 (41%)
		STKc_PKD	573..832	CDD:270984	211/258 (82%)
		S_TKc	581..833	CDD:214567	206/251 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596261
Domainoid	1	1.000	434	1.000	Domainoid score	I555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	839	1.000	Inparanoid score	I427
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm24264
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940