DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and Prkd3

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001019434.2	Gene:	Prkd3 / 313834	RGDID:	1310236	Length:	890	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	460/874 - (52%)
Similarity:	572/874 - (65%)	Gaps:	118/874 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNVLHI 70
            |:||.|.|..|::|.:.|..|:|..:|||.|..:..|.|:.|...:.::||||.|:.::.|:|.:
  Rat    60 VSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHNMNSENILQL 124

  Fly    71 INSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC 135
            |.||.|:.:..|||:||:|    ..|.|...::||:|.|||||.|||||:|||||:|||||||||
  Rat   125 ITSADEIHEGDLVEVVLSA----LATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC 185

  Fly   136 DGCGQNYHKRCVVKIPNNCN----RSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRNDSSS 196
            :|||.||||||..||||||:    |.....|.....|..|| |.......|:|.|..|.:..|..
  Rat   186 EGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPR-PLQPECVPLLSEESHTHQEPSKR 249

  Fly   197 SLNIPGRHQRTHSSGSRNGLMVL---RIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGLQCRDCQY 258
            ..:..||......       ||:   ::||||.||:||.||:||.||:||||||:|||||:||::
  Rat   250 IPSWSGRPIWMEK-------MVMCRVKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGLQCKDCKF 307

  Fly   259 NTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSD-GDDGSEYGKYKSAMSSGVNL 322
            |.||:|..|||.||.||...:......|.   |.....:.|.:| ..|||.          |::
  Rat   308 NCHKRCASKVPRDCLGEVTFNGEPSSVGT---DTDMPMDIDSNDVNSDGSR----------GLD- 358

  Fly   323 VAGRPREAPKALTNAHNSPPE----LVNGGLVDDSSVSGGETSKSSSDGQSEQSQSSTSSSPSAN 383
                ..|.|        ||||    .::...:|..              :.|:...:.|.|.|.|
  Rat   359 ----DSEEP--------SPPEDKMFFLDAADLDVE--------------RDEEPVKTISPSTSNN 397

  Fly   384 IPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKYHKELPL 448
            |||||:|||:||||::....:||||:|||||.|...||:|||||||.:|||.:|.||||:||:||
  Rat   398 IPLMRVVQSIKHTKRKSSTVVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPL 462

  Fly   449 AELLSIESHLGDPRPECN-------YCFELRLPNLSYFVGQ-------DPQVGAKEEQAVRLPPP 499
            :|:|.|.|    |:...:       :|||:....:.||||:       :|.:.|
  Rat   463 SEILRISS----PQDFTSISQGSNPHCFEIITDTVVYFVGENNGNSTHNPVLAA----------- 512

  Fly   500 DSGIGSDIAKSWETSIRQAFMHVT----------------------NTQCCESEEQVQDMGQLYQ 542
             :|:|.|:|:|||.:||||.|.||                      :...|:.:|.| |:..:||
  Rat   513 -TGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLATSISVSNCQIQENV-DISSVYQ 575

  Fly   543 IFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLER 607
            ||.||||||||||:||||.|:||.|:||||||||:|||||||:||:||||||||:.|.|:||||.
  Rat   576 IFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLEC 640

  Fly   608 MFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENV 672
            |||||||:|||||||.|||||||||..:.||.||:|||::||||:||:.||.:||||||||||||
  Rat   641 MFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENV 705

  Fly   673 LLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSL 737
            ||:|...||||||||||:||||||||||||||||||||||||||:|||||||||||||||:||||
  Rat   706 LLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSL 770

  Fly   738 SGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDK 802
            ||||||||:|||||||||||||||||||:||||.||||||||||||.||||:|||||.|.||||.
  Rat   771 SGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDY 835

  Fly   803 QTYRDLRNLEAQVGAGRYLTHEADDLRWD 831
            ||:.|||..|.::|. ||:|||:||.||:
  Rat   836 QTWLDLREFETRIGE-RYITHESDDARWE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	37/44 (84%)
		C1	223..272	CDD:197519	33/48 (69%)
		PH_PKD	396..522	CDD:269945	59/139 (42%)
		STKc_PKD	539..798	CDD:270984	214/258 (83%)
		S_TKc	547..799	CDD:214567	209/251 (83%)
Prkd3	NP_001019434.2	C1_PKD3_rpt1	145..219	CDD:410391	46/73 (63%)
		C1	267..335	CDD:412127	38/67 (57%)
		PH_PKD	410..534	CDD:269945	59/139 (42%)
		STKc_PKD	572..831	CDD:270984	214/258 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354040
Domainoid	1	1.000	436	1.000	Domainoid score	I548
eggNOG	1	0.900	-	-		E1_KOG4236
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2055
Inparanoid	1	1.050	846	1.000	Inparanoid score	I417
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm45864
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770