DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PKD and Prkd2

DIOPT Version :9

Sequence 1:NP_001262705.1 Gene:PKD / 42203 FlyBaseID:FBgn0038603 Length:906 Species:Drosophila melanogaster
Sequence 2:NP_001013917.1 Gene:Prkd2 / 292658 RGDID:1308054 Length:875 Species:Rattus norvegicus


Alignment Length:888 Identity:461/888 - (51%)
Similarity:584/888 - (65%) Gaps:115/888 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPEVTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNV 67
            |..|:|..|.|..|:.|.:||.| .|..:|.|||..::.|.|:.|...|.::||||.||.::.|:
  Rat    42 GSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANL 105

  Fly    68 LHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQG 132
            |.::.|||::.:..|||:||:||    .|.|...::||:|.||||:.|.|||.||||||||||||
  Rat   106 LQLVRSAADIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQG 166

  Fly   133 LKCDGCGQNYHKRCVVKIPNNCNRSNDATSRR--SFTLQAPRSPSGSSQQSLVSTEDSTGRNDSS 195
            |||||||.||||||...|||||   :.|..||  |.:|.:..|....|.:||..|.:...|  |:
  Rat   167 LKCDGCGLNYHKRCAFSIPNNC---SGARKRRLSSTSLASGHSVRLGSSESLPCTAEELSR--ST 226

  Fly   196 SSLNIPGRHQRTHSSGSRNG-------------LMVLRIPHTFMVHTYGIPTVCQLCKKLLKGLF 247
            :.| :|.|...:.||.|.:.             :..:::||||::|:|..|||||.|||||||||
  Rat   227 TDL-LPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRPTVCQACKKLLKGLF 290

  Fly   248 KQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKY 312
            :|||||:||::|.||:|..:||:||.|||.::          .|....|..|.|:.|        
  Rat   291 RQGLQCKDCKFNCHKRCATRVPNDCLGEALIN----------GDVPMEEAADYSEAD-------- 337

  Fly   313 KSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDGQSEQSQSSTS 377
            ||::|.                        ||.:.|::..|.......:....:|:..::|||. 
  Rat   338 KSSLSD------------------------ELEDSGVIPGSHAENALHASEEEEGEGGKAQSSL- 377

  Fly   378 SSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKY 442
                ..|||||:||||:||.::....|:|||:|||::.|...||:|||||.|.||||.:...::|
  Rat   378 ----GYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRY 438

  Fly   443 HKELPLAELLSIE--SHLGDPRPECN-YCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDSGIG 504
            :||:||:|:|::|  .:.....|..| :|||:...|::||||:.|. ||        |...||.|
  Rat   439 YKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITANVTYFVGETPG-GA--------PGGPSGQG 494

  Fly   505 SDIAKSWETSIRQAFM------------HVTNTQC----CESEEQVQ---DMGQLYQIFPDEVLG 550
            ::.|:.|||:||||.|            |..:.|.    ..|..|:|   |:..:||||||||||
  Rat   495 TEAARGWETAIRQALMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLG 559

  Fly   551 SGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPERI 615
            ||||||||||.|:||.|:||:|||||||||||||:||:|||||||::.|.|:||||.||||||::
  Rat   560 SGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV 624

  Fly   616 FVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEF 680
            |||||||.|||||||||..:|||.||:|||||||||:||::||.:||||||||||||||:|...|
  Rat   625 FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF 689

  Fly   681 PQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNE 745
            |||||||||:|||||||||||||||||||||||||.|:||||||||||||||:||||||||||||
  Rat   690 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNE 754

  Fly   746 EEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRN 810
            :|||||||||||||||.:||..|||.||||||||||||.||||:|||||.|.|||:.||:.|||.
  Rat   755 DEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRE 819

  Fly   811 LEAQVGAGRYLTHEADDLRWD----------CAGDMXPGCEPE 843
            ||.::|. ||:|||:||.|||          ..||:...|.|:
  Rat   820 LEGKMGE-RYITHESDDARWDQFVSERHGTPAEGDLGGACLPQ 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKDNP_001262705.1 C1_1 109..154 CDD:278556 36/44 (82%)
C1 223..272 CDD:197519 32/48 (67%)
PH_PKD 396..522 CDD:269945 55/140 (39%)
STKc_PKD 539..798 CDD:270984 213/258 (83%)
S_TKc 547..799 CDD:214567 207/251 (82%)
Prkd2NP_001013917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
C1_1 139..188 CDD:278556 38/48 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..247 8/25 (32%)
C1 266..315 CDD:237996 32/48 (67%)
PH_PKD 392..512 CDD:269945 55/128 (43%)
STKc_PKD 548..807 CDD:270984 213/258 (83%)
S_TKc 556..808 CDD:214567 207/251 (82%)
Important for ABL1-mediated Tyr-718 phosphorylation. /evidence=ECO:0000250|UniProtKB:Q9BZL6 725..727 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166354039
Domainoid 1 1.000 436 1.000 Domainoid score I548
eggNOG 1 0.900 - - E1_KOG4236
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 846 1.000 Inparanoid score I417
OMA 1 1.010 - - QHG48438
OrthoDB 1 1.010 - - D182843at33208
OrthoFinder 1 1.000 - - FOG0002280
OrthoInspector 1 1.000 - - otm45864
orthoMCL 1 0.900 - - OOG6_103473
Panther 1 1.100 - - LDO PTHR22968
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1509
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.770

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