DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and PRKD2

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001073349.1	Gene:	PRKD2 / 25865	HGNCID:	17293	Length:	878	Species:	Homo sapiens

Alignment Length:	895	Identity:	459/895 - (51%)
Similarity:	582/895 - (65%)	Gaps:	126/895 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GPEVTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNV 67
            |..|:|..|.|..|:.|.:||.| .|..:|.|||..::.|.|:.|...|.::||||.||.::.|:
Human    42 GSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANL 105

  Fly    68 LHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQG 132
            |.::.|:.::.:..|||:||:||    .|.|...::||:|.||||:.|.|||.||||||||||||
Human   106 LQLVRSSGDIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQG 166

  Fly   133 LKCDGCGQNYHKRCVVKIPNNCNRSNDATSRR--SFTLQAPRSPSGSSQQSLVSTEDSTGRNDSS 195
            |||||||.||||||...|||||   :.|..||  |.:|.:..|....:.:||..|.:...|  |:
Human   167 LKCDGCGLNYHKRCAFSIPNNC---SGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSR--ST 226

  Fly   196 SSLNIPGRHQRTHSSGSRNG------------LMVLRIPHTFMVHTYGIPTVCQLCKKLLKGLFK 248
            :.| :|.|...:.||.|.:.            |..:::||||::|:|..|||||.|||||||||:
Human   227 TEL-LPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFR 290

  Fly   249 QGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKYK 313
            |||||:||::|.||:|..:||:||.|||.::          .|....|..|.|:.|        |
Human   291 QGLQCKDCKFNCHKRCATRVPNDCLGEALIN----------GDVPMEEATDFSEAD--------K 337

  Fly   314 SAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSG---GETSKSS-SDGQSEQSQS 374
            ||                                 |:|:|..||   |..|::: ...:.|:.:.
Human   338 SA---------------------------------LMDESEDSGVIPGSHSENALHASEEEEGEG 369

  Fly   375 STSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQG 439
            ..:.|....|||||:||||:||.::....|:|||:|||::.|...||:|||||.|.||||.:...
Human   370 GKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTT 434

  Fly   440 SKYHKELPLAELLSIES--HLGDPRPECN-YCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDS 501
            ::|:||:||:|:|::||  :.....|..| :|||:...|.:||||:.|  |.       .|...|
Human   435 NRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMP--GG-------TPGGPS 490

  Fly   502 GIGSDIAKSWETSIRQAFM------------HVTNTQC----CESEEQVQ---DMGQLYQIFPDE 547
            |.|::.|:.|||:||||.|            |..:.|.    ..|..|:|   |:..:|||||||
Human   491 GQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDE 555

  Fly   548 VLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETP 612
            |||||||||||||.|:||.|:||:|||||||||||||:||:|||||||::.|.|:||||.|||||
Human   556 VLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETP 620

  Fly   613 ERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSD 677
            |::|||||||.|||||||||..:|||.||:|||||||||:||::||.:||||||||||||||:|.
Human   621 EKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASA 685

  Fly   678 AEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFP 742
            ..||||||||||:|||||||||||||||||||||||||.|:||||||||||||||:|||||||||
Human   686 DPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFP 750

  Fly   743 FNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRD 807
            |||:|||||||||||||||.:||..||:.||||||||||||.||||:|||||.|.|||:.||:.|
Human   751 FNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLD 815

  Fly   808 LRNLEAQVGAGRYLTHEADDLRWD--CAGDMXPG------------CEPE 843
            ||.||.::|. ||:|||:||.||:  .|... ||            |.|:
Human   816 LRELEGKMGE-RYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQ 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	36/44 (82%)
		C1	223..272	CDD:197519	32/48 (67%)
		PH_PKD	396..522	CDD:269945	55/140 (39%)
		STKc_PKD	539..798	CDD:270984	212/258 (82%)
		S_TKc	547..799	CDD:214567	206/251 (82%)
PRKD2	NP_001073349.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		C1_1	139..188	CDD:278556	38/48 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..247		8/25 (32%)
		C1	265..314	CDD:237996	32/48 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..373		6/29 (21%)
		PH_PKD	391..511	CDD:269945	55/128 (43%)
		STKc_PKD	547..806	CDD:270984	212/258 (82%)
		Important for ABL1-mediated Tyr-717 phosphorylation. /evidence=ECO:0000269\|PubMed:28428613	724..726		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..869		4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159971
Domainoid	1	1.000	436	1.000	Domainoid score	I569
eggNOG	1	0.900	-	-		E1_KOG4236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	842	1.000	Inparanoid score	I447
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm41732
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800