DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and Prkd1

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_032884.2	Gene:	Prkd1 / 18760	MGIID:	99879	Length:	918	Species:	Mus musculus

Alignment Length:	961	Identity:	475/961 - (49%)
Similarity:	603/961 - (62%)	Gaps:	168/961 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTFLFQFGSVRDAVCVPANS---LTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNV 67
            ::|..|.|..|:.|.:..:|   .:|..::::||..::.|.|:.|...|.::||||.||.::.|:
Mouse    47 ISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYDKILLFRHDPASDNI 111

  Fly    68 LHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQG 132
            |.::..|:::.:..|:|:||:||    .|.|...::||:|.||||:.|.|||.|||||:||||||
Mouse   112 LQLVKIASDIQEGDLIEVVLSAS----ATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG 172

  Fly   133 LKCDGCGQNYHKRCVVKIPNNCN------RSNDA--------TSRRSFTLQAPRSPSGSSQQSLV 183
            |||:|||.||||||..||||||:      .||.:        |:...|:...|..|       |:
Mouse   173 LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGLGTVRTASAEFSTSVPDEP-------LL 230

  Fly   184 STEDSTGRNDSSSSLNIPGRHQRTHSSG------SRNGLMV--LRIPHTFMVHTYGIPTVCQLCK 240
            |.. |.|....|.|.:..||.:|::|..      ..:.|::  :::||||::|:|..|||||.||
Mouse   231 SPV-SPGFEQKSPSESFIGREKRSNSQSYIGRPIQLDKLLMSKVKVPHTFVIHSYTRPTVCQFCK 294

  Fly   241 KLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDD 305
            |||||||:|||||:||::|.||:|..|||::|.||..::...:..|| |.|....|..||:|.:.
Mouse   295 KLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGELLSPGA-ESDVVMEEGSDDNDSER 358

  Fly   306 GSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDD--------------SSVS 356
                                                    |.||:||              ...|
Mouse   359 ----------------------------------------NSGLMDDMDEAMVQDTEMALAEGQS 383

  Fly   357 GGETSKSSSDGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKR 421
            || ......|...|.|..:.|.|.|.||||||:||||||||:|....:||||:|||||.|...||
Mouse   384 GG-AEMQDPDADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVMKEGWMVHYTSKDTLRKR 447

  Fly   422 YYWRLDSKTITLFVSEQGSKYHKELPLAELLSIE----SHLGDPRPECNYCFELRLPNLSYFVGQ 482
            :|||||||.||||.::.||:|:||:||:|:|.:|    |.| .|.....:|||:...|:.|:||:
Mouse   448 HYWRLDSKCITLFQNDTGSRYYKEIPLSEILCLEPAKPSAL-TPVGATPHCFEITTANVVYYVGE 511

  Fly   483 ---DPQVGAKEEQAVRLPPPD-----SGIGSDIAKSWETSIRQAFMHV----------------- 522
               :|...          ||:     ||||.|:|:.||.:|:.|.|.|
Mouse   512 NVVNPSSS----------PPNNSVLPSGIGPDVARMWEVAIQHALMPVIPKGSSVGSGSNSHKDI 566

  Fly   523 ---TNTQCCESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQE 584
               .:...|:.:|.| |:..:|||||||||||||||:||||.|:||.|:||||:|||||||||||
Mouse   567 SVSISVSNCQIQENV-DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE 630

  Fly   585 AQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQ 649
            :||:||||||||:.|.||||||.|||||||:|||||||.|||||||||..:|||.|.:|||||||
Mouse   631 SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQ 695

  Fly   650 ILIALKYLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEV 714
            ||:||::||.:||||||||||||||:|...||||||||||:||||||||||||||||||||||||
Mouse   696 ILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 760

  Fly   715 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNL 779
            |||||||||||||||||||||||||||||||:|||:|||||||||||||||||||..||||||||
Mouse   761 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNL 825

  Fly   780 LQVKQRKRYTVDKSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD-CAGDMXPGCEPE 843
            ||||.||||:|||:|.|.||||.||:.|||.||.::|. ||:|||:||.||: .||:..
Mouse   826 LQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECRIGE-RYITHESDDSRWEQYAGEQG------ 883

  Fly   844 AILESTTELISCSANTTTESYRRSPADCAGCHRLSDCGNSPKSEAMSDRAL 894
              |:....|||.||:.:                     :||::|....:||
Mouse   884 --LQYPAHLISLSASHS---------------------DSPEAEEREMKAL 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	35/44 (80%)
		C1	223..272	CDD:197519	33/48 (69%)
		PH_PKD	396..522	CDD:269945	60/137 (44%)
		STKc_PKD	539..798	CDD:270984	218/258 (84%)
		S_TKc	547..799	CDD:214567	212/251 (84%)
Prkd1	NP_032884.2	C1_1	145..194	CDD:278556	37/48 (77%)
		C1	277..326	CDD:237996	33/48 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..362		9/64 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..410		9/31 (29%)
		PH_PKD	422..549	CDD:269945	60/137 (44%)
		STKc_PKD	585..844	CDD:270984	218/258 (84%)
		S_TKc	593..845	CDD:214567	212/251 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850339
Domainoid	1	1.000	436	1.000	Domainoid score	I562
eggNOG	1	0.900	-	-		E1_KOG4236
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	843	1.000	Inparanoid score	I437
Isobase	1	0.950	-	0	Normalized mean entropy	S1932
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm43780
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	O	PTHR22968
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2489
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750