DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and prkd2

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	XP_021322000.1	Gene:	prkd2 / 101882608	ZFINID:	ZDB-GENE-131120-142	Length:	923	Species:	Danio rerio

Alignment Length:	925	Identity:	469/925 - (50%)
Similarity:	591/925 - (63%)	Gaps:	139/925 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGPE----VTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHD 61
            :.||.    |:|:.|.|..|::|.:| .:..|..:|.:||..::.|.|:.|...:.::||||.||
Zfish    65 LPGPPAPAGVSFIIQIGLTRESVLLP-QTADLAYVKQIACSIVDQKFPECGFYGIYDKILLFKHD 128

  Fly    62 YSTPNVLHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLF 126
            .|:.|:|.::.:.:::.:..|||:||:|:    .|.|...::||:||||||:.|.|||.||||||
Zfish   129 TSSNNILQLVKAVSDIQEGDLVEVVLSAA----ATFEDFQIRPHALNVHSYRAPAFCDHCGEMLF 189

  Fly   127 GLVRQGLKCDGCGQNYHKRCVVKIPNNCNRSNDATSRRSFT--LQAPRSPSGSSQQSLVSTEDST 189
            |||||||||||||.||||||...|||||   :.|..||..|  |.:.:|...|:.:||.|...|.
Zfish   190 GLVRQGLKCDGCGLNYHKRCAFSIPNNC---SGARKRRLSTTSLTSSQSLRLSTTESLSSLNSSM 251

  Fly   190 GRNDSS---SSLNIPGRHQRTHSSGSR--NGLMV---------LRIPHTFMVHTYGIPTVCQLCK 240
            ...::|   |...:|    ||.|...|  .|..|         :::||||.||:|..|||||.||
Zfish   252 TSEEASLIRSHTQMP----RTPSEARRFYTGRPVHLDKILMTKVKVPHTFAVHSYTRPTVCQYCK 312

  Fly   241 KLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDD 305
            :||:|||:|||||:||::|.||:|..|||:||.||. |..|.....| |....:..||.|||
Zfish   313 RLLRGLFRQGLQCKDCKFNCHKRCAYKVPNDCLGET-LDILSPSTDA-EVPMDYSSEFSDSD--- 372

  Fly   306 GSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDS----SVSGGETSKSSSD 366
                   ||:                                 |:|||    |:.|..:..||.|
Zfish   373 -------KSS---------------------------------LIDDSDEACSIPGSFSPDSSQD 397

  Fly   367 GQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTI 431
                    .:|...|:||||||:||||:.|.:|...|:||||:|||::.|...||:|||||.|.|
Zfish   398 --------RSSGDQSSNIPLMRVVQSVRQTTRRSSTAIKEGWMVHYSNKDTLRKRHYWRLDCKCI 454

  Fly   432 TLFVSEQGSKYHKELPLAELLSIESHLGD----PRPECNYCFELRLPNLSYFVGQDPQVGAKEEQ 492
            .||.::..:||:||:||:|:|.:.| .||    |.....:|||:....:.||||:||...:....
Zfish   455 ILFQNDTTNKYYKEIPLSEILEVRS-AGDFSLVPAGTSPHCFEIMTGTMIYFVGEDPNTSSPSSS 518

  Fly   493 AVRLP------PPDSGIGSDIAKSWETSIRQAFM------------HVTNTQC----CESEEQVQ 535
            ...||      .|:||:|.::||.|||:||||.|            |..:.|.    ..|..|:|
Zfish   519 ISGLPVSPSSVVPNSGVGREVAKGWETAIRQALMPVIFQDNPPAEGHTPHRQASVSISVSNSQIQ 583

  Fly   536 ---DMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNI 597
               |:|..||||.|||||||||||||||.|:|:.|:||:|||||||||||||:||:|||||||::
Zfish   584 ENVDIGMFYQIFADEVLGSGQFGVVYGGKHRKSGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL 648

  Fly   598 SHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNI 662
            .|.|:||||.||||||::|||||||.|||||||||..:|||.||:|||||||||.||::||.:||
Zfish   649 RHLGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILAALRHLHFKNI 713

  Fly   663 VHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMW 727
            ||||||||||||:|...||||||||||:|||||||||||||||||||||||||.|:|||||||||
Zfish   714 VHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMW 778

  Fly   728 SVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDK 792
            |||||:||||||||||||:|||||||.||||||||||||:||.:|.||||||||||.||||:|||
Zfish   779 SVGVIMYVSLSGTFPFNEDEDINDQIHNAAFMYPPNPWKQISPDATDLINNLLQVKMRKRYSVDK 843

  Fly   793 SLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWD------------------CAGDMXPG 839
            ||.|.:|||.||:.|||.||:::|. ||:|||:||.||.                  .|.|. .|
Zfish   844 SLSHAYLQDYQTWLDLRELESKLGE-RYITHESDDSRWQQYARDHTLPYPPHLVPPPPASDDEDG 907

  Fly   840 CEPEAILESTTELIS 854
            .| :|.::..||.:|
Zfish   908 NE-DADMQGLTERVS 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	36/44 (82%)
		C1	223..272	CDD:197519	32/48 (67%)
		PH_PKD	396..522	CDD:269945	59/147 (40%)
		STKc_PKD	539..798	CDD:270984	211/258 (82%)
		S_TKc	547..799	CDD:214567	206/251 (82%)
prkd2	XP_021322000.1	C1_1	168..217	CDD:278556	39/48 (81%)
		C1	295..344	CDD:237996	32/48 (67%)
		PH_PKD	419..554	CDD:269945	59/135 (44%)
		STKc_PKD	592..847	CDD:270984	210/254 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	434	1.000	Domainoid score	I555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48438
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103473
Panther	1	1.100	-	-	LDO	PTHR22968
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930