DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PKD and Prkd2

DIOPT Version :10

Sequence 1:NP_001262705.1 Gene:PKD / 42203 FlyBaseID:FBgn0038603 Length:906 Species:Drosophila melanogaster
Sequence 2:NP_849231.1 Gene:Prkd2 / 101540 MGIID:2141917 Length:875 Species:Mus musculus


Alignment Length:888 Identity:460/888 - (51%)
Similarity:583/888 - (65%) Gaps:115/888 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPEVTFLFQFGSVRDAVCVPANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPNV 67
            |..|:|..|.|..|:.|.:||.| .|..:|.|||..::.|.|:.|...|.::||||.||.::.|:
Mouse    42 GSGVSFHIQIGLTREFVLLPAAS-ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANL 105

  Fly    68 LHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQG 132
            |.::.|||::.:..|||:||:||    .|.|...::||:|.||||:.|.|||.||||||||||||
Mouse   106 LQLVRSAADIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQG 166

  Fly   133 LKCDGCGQNYHKRCVVKIPNNCNRSNDATSRR--SFTLQAPRSPSGSSQQSLVSTEDSTGRNDSS 195
            |||||||.||||||...|||||   :.|..||  |.:|.:..|....|.:||..|.:...|  |:
Mouse   167 LKCDGCGLNYHKRCAFSIPNNC---SGARKRRLSSTSLASGHSVRLGSSESLPCTAEELSR--ST 226

  Fly   196 SSLNIPGRHQRTHSSGSRNG-------------LMVLRIPHTFMVHTYGIPTVCQLCKKLLKGLF 247
            :.| :|.|...:.||.|.:.             :..:::||||::|:|..|||||.|||||||||
Mouse   227 TDL-LPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRPTVCQACKKLLKGLF 290

  Fly   248 KQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKERDNFFREEFDDSDGDDGSEYGKY 312
            :|||||:||::|.||:|..:||:||.|||.::          .|....|..|.|:.|        
Mouse   291 RQGLQCKDCKFNCHKRCATRVPNDCLGEALIN----------GDVPMEEAADYSEAD-------- 337

  Fly   313 KSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSGGETSKSSSDGQSEQSQSSTS 377
            ||::|.                        ||.:.|::..|.......:....:|:..::|||. 
Mouse   338 KSSISD------------------------ELEDSGVIPGSHSESALHASEEEEGEGHKAQSSL- 377

  Fly   378 SSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKY 442
                ..|||||:||||:||.::....|:|||:|||::.|...||:|||||.|.||||.:...::|
Mouse   378 ----GYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRY 438

  Fly   443 HKELPLAELLSIE--SHLGDPRPECN-YCFELRLPNLSYFVGQDPQVGAKEEQAVRLPPPDSGIG 504
            :||:||:|:|::|  .:.....|..| :|||:...|::||||:.|. ||        |...||.|
Mouse   439 YKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITANVTYFVGETPG-GA--------PGGPSGQG 494

  Fly   505 SDIAKSWETSIRQAFM------------HVTNTQC----CESEEQVQ---DMGQLYQIFPDEVLG 550
            ::..:.|||:||||.|            |..:.|.    ..|..|:|   |:..:||||||||||
Mouse   495 TEAVRGWETAIRQALMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLG 559

  Fly   551 SGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPERI 615
            ||||||||||.|:||.|:||:|||||||||||||:||:|||||||::.|.|:||||.||||||::
Mouse   560 SGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV 624

  Fly   616 FVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSSDAEF 680
            |||||||.|||||||||..:|||.||:|||||||||:||::||.:||||||||||||||:|...|
Mouse   625 FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF 689

  Fly   681 PQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNE 745
            |||||||||:|||||||||||||||||||||||||.|:||||||||||||||:||||||||||||
Mouse   690 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNE 754

  Fly   746 EEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRN 810
            :|||||||||||||||.:||..|||.||||||||||||.||||:|||||.|.|||:.||:.|||.
Mouse   755 DEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRE 819

  Fly   811 LEAQVGAGRYLTHEADDLRWD----------CAGDMXPGCEPE 843
            ||.::|. ||:|||:||.|||          ..||:...|.|:
Mouse   820 LEGKMGE-RYITHESDDARWDQFVAERHGTPAEGDLGGACLPQ 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PKDNP_001262705.1 C1_PKD_rpt1 102..157 CDD:410345 41/54 (76%)
C1_PKD_rpt2 222..275 CDD:410346 35/52 (67%)
PH_PKD 396..522 CDD:269945 54/140 (39%)
STKc_PKD 539..798 CDD:270984 213/258 (83%)
Prkd2NP_849231.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
C1_PKD2_rpt1 129..201 CDD:410390 47/74 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..247 8/25 (32%)
C1_PKD2_rpt2 255..332 CDD:410393 40/86 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..374 11/73 (15%)
PH_PKD 392..512 CDD:269945 54/128 (42%)
STKc_PKD 548..807 CDD:270984 213/258 (83%)
Important for ABL1-mediated Tyr-718 phosphorylation. /evidence=ECO:0000250|UniProtKB:Q9BZL6 725..727 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

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