DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD and prkd1

DIOPT Version :9

Sequence 1:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster
Sequence 2:	NP_001120884.1	Gene:	prkd1 / 100151704	XenbaseID:	XB-GENE-487626	Length:	860	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	470/895 - (52%)
Similarity:	586/895 - (65%)	Gaps:	144/895 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GPEVTFLFQFGSVRDAVCVP-ANSLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYSTPN 66
            |..::...|.|..|:.|.:| ...|:|..::::||..::.|.|:.|...:.::||||.||.::.|
Frog    14 GTGLSLQIQIGLSREPVLLPEPGELSLGAVREMACSIVDQKFPECGFYGMYDKILLFRHDPNSEN 78

  Fly    67 VLHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQ 131
            :|.::.|.|::.:..|:|:||:||    .|.|...::||:|.||||:.|.|||.|||||:|||||
Frog    79 ILQLVKSEADIQEGDLIEVVLSAS----ATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQ 139

  Fly   132 GLKCDGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPRSPSGSSQQSLVSTEDSTGRND--- 193
            ||||:|||.||||||..||||||   :....||...:    |.:|.|....:|.|..:...|
Frog   140 GLKCEGCGLNYHKRCAFKIPNNC---SGVRKRRLSNV----SLTGLSSIRTLSVEPLSSAPDEPL 197

  Fly   194 --SSSSLNIPGRHQRTHSSGS-----------RNGLMVLRIPHTFMVHTYGIPTVCQLCKKLLKG 245
              .|.|.:..|||.|   |||           :..|..:::||||::|:|..|||||.|||||||
Frog   198 LQKSPSESFLGRHSR---SGSQLHIGRPIKLDKFFLTKVKVPHTFVIHSYTRPTVCQHCKKLLKG 259

  Fly   246 LFKQGLQCRDCQYNTHKKCMDKVPHDCTGE----AQLSQLQIQAGAKERDNFFR-EEFDDSDGDD 305
            ||:|||||:||::|.||:|..:|||:|.||    ..||.:.::.|:.  ||..| |:.|:|...|
Frog   260 LFRQGLQCKDCKFNCHKRCASRVPHNCLGEDAINGDLSDVMMEEGSD--DNESRPEDMDESPTTD 322

  Fly   306 GSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGLVDDSSVSG-----GETSKSSS 365
                                                         .:.|:||     ||..:...
Frog   323 ---------------------------------------------SEGSISGCRSENGEMQEPDQ 342

  Fly   366 DGQSEQSQSSTSSSPSA--NIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVKRYYWRLDS 428
            |    |..|..:.||||  ||||||:||||||||::....:||||:|||||.|...||:||||||
Frog   343 D----QDASDRTISPSASNNIPLMRVVQSVKHTKRKSSSVMKEGWMVHYTSKDPMRKRHYWRLDS 403

  Fly   429 KTITLFVSEQGSKYHKELPLAELLSIE--SHLGDPRPECN-YCFELRLPNLSYFVGQDPQVGAKE 490
            |.||||.::.||||:||:||:|:||:|  ..|....|..| :|||:...|:.|:||::
Frog   404 KCITLFQNDTGSKYYKEIPLSEILSLEPAKDLSLLCPGANPHCFEITTANVVYYVGEN------- 461

  Fly   491 EQAVRLP---PPD-------SGIGSDIAKSWETSIRQAFMHVT-------NTQ-----------C 527
                 ||   |||       ||.|.|||:.||.:|:.|.|.|.       :||           .
Frog   462 -----LPQPVPPDMGNVMLTSGAGLDIARMWEIAIQHALMPVNPKGANDGSTQHRDVSISISVSN 521

  Fly   528 CESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVA 592
            |:..|.| |:..:|||||||||||||||:||||.|:||.|:||||:|||||||||||:||:||||
Frog   522 CQVHENV-DISSVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVA 585

  Fly   593 ILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYL 657
            ||||:.|.||||||.|||||||:|||||||.|||||||||..:|||.||:||||:||||:||::|
Frog   586 ILQNLHHQGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPERITKFLVTQILVALRHL 650

  Fly   658 HSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR 722
            |.:||||||||||||||:|...||||||||||:|||||||||||||||||||||||||||:||||
Frog   651 HFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNRGYNR 715

  Fly   723 SLDMWSVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKR 787
            |||||||||||||||||||||||:|||:|||||||||||||||||||.:||||||||||||.|||
Frog   716 SLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISPDAIDLINNLLQVKMRKR 780

  Fly   788 YTVDKSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRW-----DC 832
            |:|||:|.|.||||.||:.|||.||.::|. ||:|||:||.||     ||
Frog   781 YSVDKTLNHPWLQDYQTWLDLRELECKIGE-RYITHESDDPRWQQYSEDC 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD	NP_001262705.1	C1_1	109..154	CDD:278556	35/44 (80%)
		C1	223..272	CDD:197519	33/48 (69%)
		PH_PKD	396..522	CDD:269945	63/138 (46%)
		STKc_PKD	539..798	CDD:270984	217/258 (84%)
		S_TKc	547..799	CDD:214567	211/251 (84%)
prkd1	NP_001120884.1	C1_1	113..162	CDD:365894	37/48 (77%)
		C1	237..286	CDD:237996	33/48 (69%)
		PH_PKD	371..498	CDD:269945	63/138 (46%)
		STKc_PKD	532..791	CDD:270984	217/258 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	839	1.000	Inparanoid score	I440
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D182843at33208
OrthoFinder	1	1.000	-	-		FOG0002280
OrthoInspector	1	1.000	-	-		otm48955
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060